Zobrazeno 1 - 10
of 650
pro vyhledávání: '"W. Goldberg"'
Autor:
Gregory W. Goldberg, Manjunatha Kogenaru, Sarah Keegan, Max A. B. Haase, Larisa Kagermazova, Mauricio A. Arias, Kenenna Onyebeke, Samantha Adams, Daniel K. Beyer, David Fenyö, Marcus B. Noyes, Jef D. Boeke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract DNA targeting Class 2 CRISPR-Cas effector nucleases, including the well-studied Cas9 proteins, evolved protospacer-adjacent motif (PAM) and guide RNA interactions that sequentially license their binding and cleavage activities at protospacer
Externí odkaz:
https://doaj.org/article/3bdeec378a054518868d5fd4d1eac2b8
Autor:
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROT
Externí odkaz:
https://doaj.org/article/ec006f9560824ea494be6041bb1eeb60
Autor:
Valentina Aravena-Ramírez, Danny Fuentes-Castillo, Sibelle T. Vilaça, Daphne W. Goldberg, Fernanda Esposito, Taiana T. Silva-Pereira, Herrison Fontana, Fábio P. Sellera, Nilton Lincopan
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 36, Iss , Pp 389-392 (2024)
ABSTRACT: Background: Carbapenemase-producing Citrobacter freundii has been reported as a leading cause of healthcare-associated infections. Particularly, C. freundii belonging to the sequence type (ST) 18 is considered to be an emerging nosocomial c
Externí odkaz:
https://doaj.org/article/af907d32eafe4f66b90855f71c8f4473
Autor:
Natalie Young, Zizhao Gui, Suleiman Mustafa, Kleopatra Papa, Emily Jessop, Elizabeth Ruddell, Laura Bevington, Roy A. Quinlan, Adam M. Benham, Martin W. Goldberg, Boguslaw Obara, Iakowos Karakesisoglou
Publikováno v:
Cells, Vol 13, Iss 11, p 906 (2024)
Eukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope l
Externí odkaz:
https://doaj.org/article/c97d31bf16a348109f2b4e6bd75f54e5
Autor:
Fábio P. Sellera, Danny Fuentes-Castillo, Bruna Fuga, Daphne W. Goldberg, Cristiane K.M. Kolesnikovas, Nilton Lincopan
Publikováno v:
One Health, Vol 17, Iss , Pp 100590- (2023)
Olive ridley (Lepidochelys olivacea) turtles migrate across tropical regions of the Atlantic, Pacific, and Indian Oceans. Worryingly, olive ridley populations have been declining substantially and is now considered a threatened species. In this regar
Externí odkaz:
https://doaj.org/article/e4b6ff23b59a46f5a0ac23446d063c28
Autor:
Danny Morick, Vanessa M. Bachmann, Eli Shemesh, Ana Maria Botero-Anug, Ziv Zemach-Shamir, Zahi Aizenberg, Nadav Davidovich, Daphne W. Goldberg, Gaston Kan, Ron Ofri, Dan Tchernov, Yaniv Levy
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Spirorchiid blood flukes are widespread in sea turtles, causing disease and mortality in their populations, with high prevalence in several ocean basins. Besides being leading parasitic causes of sea turtle strandings in several parts of the world, t
Externí odkaz:
https://doaj.org/article/7d58de8cbad547fdb911c6c3fce253e1
Autor:
Gregory W. Goldberg, Jeffrey M. Spencer, David O. Giganti, Brendan R. Camellato, Neta Agmon, David M. Ichikawa, Jef D. Boeke, Marcus B. Noyes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The PAM specificity of SpCas9 can be altered with positive selection during directed evolution. Here the authors use simultaneous positive and negative selection to improve activity on NAG PAMs while reducing activity on NGG PAMs.
Externí odkaz:
https://doaj.org/article/3e675de09c284972a7413a9b4147d955
Autor:
Fábio P. Sellera, Brenda Cardoso, Danny Fuentes-Castillo, Fernanda Esposito, Elder Sano, Herrison Fontana, Bruna Fuga, Daphne W. Goldberg, Lourdes A. V. Seabra, Marzia Antonelli, Sandro Sandri, Cristiane K. M. Kolesnikovas, Nilton Lincopan
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Carbapenemase-producing Enterobacterales are rapidly spreading and adapting to different environments beyond hospital settings. During COVID-19 lockdown, a carbapenem-resistant NDM-1-positive Escherichia coli isolate (BA01 strain) was recovered from
Externí odkaz:
https://doaj.org/article/df92c3dca77b45dc8041e9c4ae0aa7b4
Autor:
Fábio P. Sellera, Miriam R. Fernandes, Bruna Fuga, Herrison Fontana, Felipe Vásquez-Ponce, Daphne W. Goldberg, Daniel F. Monte, Larissa Rodrigues, Adriana R. Cardenas-Arias, Ralf Lopes, Brenda Cardoso, Daniela G. C. Costa, Fernanda Esposito, Nilton Lincopan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT During a surveillance study conducted to assess the occurrence and genomic landscape of critical priority pathogens circulating at the human-animal-environment interface in Brazil, as part of the Grand Challenges Explorations-New Approaches
Externí odkaz:
https://doaj.org/article/67e0cceca5e14c6f9768fb9b2bf8ea1e
Autor:
Matthew King, Melissa Chapman, Vasu Sah, Paul Lyne, Alexey Revenko, Charles Sinclair, Ben Johnson, Maneesh Singh, Andrew Watt, Maelle Mairesse, Larissa S Carnevalli, Alison Peter, Molly Taylor, Lisa Hettrick, Stephanie Klein, Anisha Solanki, Danielle Gattis, Adina M Hughes, Lukasz Magiera, Gozde Kar, Lucy Ireland, Deanna A Mele, Josephine Walton, Mark Edbrooke, Simon T Barry, Stephen Fawell, Frederick W Goldberg, A Robert MacLeod
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/f65818566663472ca06c1db1ef39c009