Výsledky vyhledávání

z-Leucinyl-Leucinyl-Norleucinal Induces Apoptosis of Human Glioblastoma Tumor–Initiating Cells by Proteasome Inhibition and Mitotic Arrest Response

Autor: Antonio Daga, Francesco Romeo, Emanuela Biollo, Andrea Fabiano, Alice Melotti, Giorgio Corte, Massimiliano Monticone, Massimo E. Maffei, Marina Fabbi, Patrizio Castagnola, W. Giaretti

Publikováno v: Molecular Cancer Research. 7:1822-1834

γ-secretase inhibitors have been proposed as drugs able to kill cancer cells by targeting the NOTCH pathway. Here, we investigated two of such inhibitors, the Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle) and the N-[N-(3,5-difluorophenacetyl)-l-alanyl]-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::346f5b6f031ac1ac13851a9e6614734f
https://doi.org/10.1158/1541-7786.mcr-09-0225

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DNA-ploidy analysis within selected regions of colorectal adenomas containing carcinoma

Autor: N. Pujic, A. Divinci, W. Giaretti, Mauro Risio, F. P. Rossini, E. Geido, A. Rapallo

Publikováno v: International journal of oncology. 3(5)

In order to better understand the relationship of DNA ploidy, dysplasia, early cancer, and colorectal tumor progression, 11 colorectal adenomas containing carcinoma invading the submucosa were investigated using DNA flow cytometry. Multiple frozen sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213597f666f97b93fcfbf3256c6bef79
https://pubmed.ncbi.nlm.nih.gov/21573457

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A model on the origin and evolution of DNA aneuploidy

Autor: W, Giaretti

Publikováno v: International journal of oncology. 2(2)

A model on the origin and evolution of DNA aneuploidy based on a postulated mechanism of DNA asymmetrical cell division is presented. Asymmetry in cell division would be at the origin of hypodiploid cells in the near-diploid region. Tetraploidization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c13178b839477a897f4b8184df5fe9b4
https://pubmed.ncbi.nlm.nih.gov/21573531

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Cell cycle dependent alterations of chromatin structure in situ as revealed by the accessibility of the nuclear protein AF-2 to monoclonal antibodies

Autor: Ulrich Pfeffer, A. Di Vinci, Giorgio Vidali, W. Giaretti, Elio Geido

Publikováno v: Europe PubMed Central

We have recently described a novel nuclear antigen, AF-2, which is related to cell cycle dependent alterations of chromatin structure. We show by two parameter flow cytometry on a cell by cell basis that the antigen is accessible to specific monoclon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e44e989ce75371c98b949290283b0c
https://doi.org/10.1002/jcp.1041490328

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Prognostic significance of nuclear DNA content in human neuroepithelial tumors

Autor: W Giaretti, S Gentile, Marco Danova, Anna Riccardi, A Di Vinci, F Merlo, Giorgio Butti, E Geido, Giuliano Mazzini, P. Gaetani

Publikováno v: International Journal of Cancer. 48:663-667

The relationship between survival and flow cytometric DNA-ploidy and other prognostic factors such as histological subtype, anatomical tumor site, patient sex and age was investigated in 153 patients with intracranial neuroepithelial tumors who under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9842eafc91f826dcb78ad398f760969
https://doi.org/10.1002/ijc.2910480505

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Neurite outgrowth and cell cycle kinetic changes induced by cis-diamminedichloroplatinum II and retinoic acid in a human neuroblastoma cell line

Autor: Daniela Di Martino, B. Marsano, W. Giaretti, Gian Paolo Tonini, Andrea Cara, C Avignolo, A. Di Vinci

Publikováno v: Cancer Letters. 52:101-106

The aim of this study was to analyze by flow cytometry the effect of cis-diamminedichloroplatinum II (CDDP) and retinoic acid (RA) on the cell cycle of a neuroblastoma cell line (SK-N-BE (2)C NB) and to correlate the kinetic data with cell morphology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e9bf5cd37944ebb814211bbc875de9
https://doi.org/10.1016/0304-3835(90)90251-r

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