Zobrazeno 1 - 10
of 35
pro vyhledávání: '"W. George Lai"'
Autor:
Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging a
Externí odkaz:
https://doaj.org/article/0260063af8414162a61d45c6971191f1
Autor:
Anshul Gupta, Jennifer L. Liras, Stephen Fowler, W. George Lai, Jane R. Kenny, Jonathan A. Phillips, Jinping Gan, Niresh Hariparsad, David B. Duignan, Wen Li Kelly Chen
Publikováno v:
Lab on a chip. 20(3)
Over the last decade, progress has been made on the development of microphysiological systems (MPS) for absorption, distribution, metabolism, and excretion (ADME) applications. Central to this progress has been proof of concept data generated by acad
Autor:
Sherri Smith, Darrell Nix, Nathalie Rioux, Pete Smith, Joanne Schindler, Amy Kim, Federico Colombo, Y Amy Siu, W. George Lai
H3B-8800, a novel orally available modulator of the SF3b complex, which potently and preferentially kills spliceosome-mutant tumor cells, is in clinical development for the treatment of advanced myeloid malignancies. We characterized the pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ad5cf1dd1b6387552a1d946c35242
Autor:
W. George Lai, Min-Kun Chang, Cynthia A. Zamora, Maiko Nomoto, Y. Amy Siu, Peter Boyd, Edgar Schuck, Jagadeesh Aluri, Bhaskar Rege, Sanae Yasuda, Jim Ferry
Publikováno v:
British Journal of Clinical Pharmacology. 84:952-960
Aims Avatrombopag, a thrombopoietin receptor agonist, is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A. We assessed three drug-drug interactions of avatrombopag as a victim with dual or selective CYP2C9/3A inhibitors and inducers. Methods This w
Autor:
Markus Warmuth, Manav Korpal, Deepti Banka, Peter Fekkes, Pavan Kumar, Andrew Hart, Lihua Yu, Ping Zhu, Lorna Helen Mitchell, Joyce Yang, W. George Lai, Amy Kim, Craig Karr, Pete Smith, Tarek Sahmoud, Xiaoling Puyang, Sherri Smith, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Victoria Rimkunas, Huilan Yao, Sean Eckley, Allison Davis, Silvia Buonamici, Crystal MacKenzie, V. Subramanian, Jeremy Wu, Zheng Guo Zhu, Christopher Rowbottom, Reynolds Dominic, Nicholas A. Larsen, Nathalie Rioux, Sean Irwin, Craig Furman
Publikováno v:
Cancer Research. 77:DDT01-04
Mutations in the estrogen receptor (ER) are detected in up to 30% of patients that initially respond but subsequently relaps to anti-endocrine therapies. ERα mutations, likely through constitutively activating ERα, can functionally confer resistanc
Autor:
Kazutomi Kusano, Edgar Schuck, Michiko Sugawara, W. George Lai, Krista Condon, Christopher DesJardins, Earvin Liang
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Eribulin, a synthetic analog of the natural product halichondrin B, is a microtubule dynamics inhibitor. In this study, we report the pharmacokinetic profiles of eribulin in mice, rats, and dogs following intravenous administrations with opti
Autor:
Y. Amy Siu, W. George Lai
Publikováno v:
Drug Metabolism and Disposition. 45:183-189
Accurately assessing the contribution of cytochrome P450 (P450) isoforms to overall metabolic clearance is important for prediction of clinical drug-drug interactions (DDIs). The relative activity factor (RAF) approach in P450 reaction phenotyping as
Autor:
Kristian Jensen, Wayne Tang, Mary Grimes, David Calkins, W. George Lai, Sayan Mondal, Victoria A. Feher, Jeff Bell, Wu Yin, Fiona M. McRobb, Shulu Feng, Michael Trzoss, Goran Krilov, Hamish Wright, Andrew Placzek, Robert Pelletier, Morgan Lawrenz, Nie Zhe, Aleksey Gerasyuto, Karen Akinsanya
Publikováno v:
Blood. 136:30-30
Introduction: MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1), was identified as a translocation protein fused with cIAP2 in mucosa-associated lymphoid tissue (MALT) B cell lymphomas. MALT1, a key mediator of NF-κB signali
Autor:
James J. Vornov, Ying Wu, Kenichi Nomoto, Larisa Reyderman, Nancy Wong, Christopher DesJardins, Yanke Yu, Bruce A. Littlefield, Krystyna M. Wozniak, W. George Lai, Barbara S. Slusher
Publikováno v:
Cancer Research. 76:3332-3339
Chemotherapy-induced peripheral neuropathy is a dose-limiting side effect of many antineoplastic agents, but the mechanisms underlying the toxicities are unclear. At their MTDs, the microtubule-binding drugs paclitaxel and ixabepilone induce more sev
Autor:
Heidi J. Einolf, Susanna Tse, Tonika Bohnert, Sirimas Sudsakorn, Ying-Hong Wang, David Moore, Jim Keirns, Ling He, Robert L. Walsky, Rangaraj Narayanan, Wanping Geng, Aarti Patel, Louis Leung, W. George Lai, Xiaoqing Yang, Ralph Stearns, Dieter Lang, Michael Sinz, Yuan Chen, Chuang Lu, Jan Wahlstrom, Ian Templeton
Publikováno v:
Drug Metabolism and Disposition. 44:1399-1423
Under the guidance of the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ), scientists from 20 pharmaceutical companies formed a Victim Drug-Drug Interactions Working Group. This working group has conducted a rev