Zobrazeno 1 - 10
of 138
pro vyhledávání: '"W. Gebhard"'
Autor:
Lori A. Hazlehurst, Anne E. Cress, Mark L. McLaughlin, Rachid Baz, Rajesh R. Nair, Anthony W. Gebhard, Michael F. Emmons
PDF file - 327K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e4d80a46f1e4f0f48a2074e22df7ff
https://doi.org/10.1158/1535-7163.22497066.v1
https://doi.org/10.1158/1535-7163.22497066.v1
Autor:
Lori A. Hazlehurst, Mark L. McLaughlin, John M. Koomen, Raul F. Argilagos, Michael F. Emmons, Rajesh R. Nair, Priyesh Jain, Anthony W. Gebhard
PDF file - 100K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4cf1db07a2a26702593051934a8752
https://doi.org/10.1158/1535-7163.22497660.v1
https://doi.org/10.1158/1535-7163.22497660.v1
Autor:
Lori A. Hazlehurst, Anne E. Cress, Mark L. McLaughlin, Rachid Baz, Rajesh R. Nair, Anthony W. Gebhard, Michael F. Emmons
We recently reported that the β1 integrin antagonist, referred to as HYD1, induces necrotic cell death in myeloma cell lines as a single agent using in vitro and in vivo models. In this article, we sought to delineate the determinants of sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67324d88e64e58ca3c88cb2b7ac3efac
https://doi.org/10.1158/1535-7163.c.6535488
https://doi.org/10.1158/1535-7163.c.6535488
Autor:
Lori A. Hazlehurst, Mark L. McLaughlin, John M. Koomen, Raul F. Argilagos, Michael F. Emmons, Rajesh R. Nair, Priyesh Jain, Anthony W. Gebhard
PDF file - 903K, Supplementary Figure S1: MTI-101 is more potent in U266 cell line than linear parent peptide and biotinylated peptides still retain bioactivity; Supplementary Figure S2: Biotin-HYD1 binding complex in NCI-H929 and U266 MM cell lines;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70be2e850c73a85497dce9e466ca637d
https://doi.org/10.1158/1535-7163.22497657.v1
https://doi.org/10.1158/1535-7163.22497657.v1
Autor:
Lori A. Hazlehurst, Mark L. McLaughlin, John M. Koomen, Raul F. Argilagos, Michael F. Emmons, Rajesh R. Nair, Priyesh Jain, Anthony W. Gebhard
Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma cell lines. Because of the intriguing biological activity and promising in vivo activity of HYD1, we pursued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed3cd763c19815b7f2427753ebe2253
https://doi.org/10.1158/1535-7163.c.6535680
https://doi.org/10.1158/1535-7163.c.6535680
Autor:
Swetha Tati, John C. Fisk, Julia Abdullah, Loukia Karacosta, Taylor Chrisikos, Padraic Philbin, Susan Morey, Diala Ghazal, Fatma Zazala, Joseph Jessee, Sally Quataert, Stephen Koury, David Moreno, Jing Ying Eng, Vladislav V. Glinsky, Olga V. Glinskii, Muctarr Sesay, Anthony W. Gebhard, Karamveer Birthare, James R. Olson, Kate Rittenhouse-Olson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 9, Pp 716-733 (2017)
JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag) which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancer
Externí odkaz:
https://doaj.org/article/0e4347110852469fa6605b279d490040
Autor:
Swetha Tati, John C. Fisk, Julia Abdullah, Loukia Karacosta, Taylor Chrisikos, Padraic Philbin, Susan Morey, Diala Ghazal, Fatma Zalzala, Joseph Jessee, Sally Quataert, Stephen Koury, David Moreno, Jing Ying Eng, Vladislav V. Glinsky, Olga V. Glinskii, Muctarr Sesay, Anthony W. Gebhard, Karamverr Birthare, James R. Olson, Kate Rittenhouse-Olson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 1, p 118 (2018)
Externí odkaz:
https://doaj.org/article/c9bc78e973d5444899949cdb84cce44e
Autor:
David B. Badger, Daniel N. Santiago, Rajesh R. Nair, Ted J. Gauthier, Anthony W. Gebhard, Sridhar Reddi Kaulagari, Yi Liang, Lori A. Hazlehurst, Priyesh Jain, Philip Murray, Wayne C. Guida, MohanRaja Kumar, Mark L. McLaughlin
Publikováno v:
Peptide science (Hoboken, N.J.). 113(3)
HYD1 is an all D-amino acid linear 10-mer peptide that was discovered by one-bead-one-compound screening. HYD1 has five hydrophobic amino acids flanked by polar amino acids. Alanine scanning studies showed that alternating hydrophobic amino acid resi
Autor:
Julia Abdullah, Diala Ghazal, Muctarr Sesay, John C. Fisk, Karamveer Birthare, Anthony W. Gebhard, Jing Ying Eng, Swetha Tati, Joseph Jessee, Stephen T. Koury, James R. Olson, David Moreno, Olga V. Glinskii, Taylor Chrisikos, Sally A. Quataert, Loukia G. Karacosta, Vladislav V. Glinsky, Susan Morey, Kate Rittenhouse-Olson, Fatma Zazala, Padraic Philbin
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 9, Pp 716-733 (2017)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag) which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancer
Autor:
Rawle Francis, Said M. Sebti, Stephane Betzi, Gunda I. Georg, Andreas Becker, R. Alam, Joseph S. Tash, Huijong Han, Aslamuzzaman Kazi, Lori A. Hazlehurst, Ernst Schönbrunn, Anthony W. Gebhard, Mathew P. Martin, Ramappa Chakrasali, Christopher L. Cubitt, Sudhakar Jakkaraj
Publikováno v:
Journal of Medicinal Chemistry. 56:3768-3782
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009 – 0.0015 µM) from a