Zobrazeno 1 - 10
of 19
pro vyhledávání: '"W. Gary Tarpley"'
Autor:
Richard A. Nugent, Donn G. Wishka, Lester A. Dolak, Azhwarsamy Jeganathan, Eric P. Seest, Laurice A. Kopta, Randall G. Stehle, Joel Morris, Wendy L. White, Stephen T. Schlachter, Janice M. Friis, Susan M. Poppe, Wade J. Adams, Murphy Michael J, David R. Graber, Robert A. Olmsted, Fusen Han, John D. Hosley, Cleek Gary J, Richard L. Voorman, Poel Toni-Jo, and W. Gary Tarpley, William Watt, Keiser Bj, Y. Yagi, Kevin Stefanski, Richard C. Thomas, Steven M. Swaney, Thomas M. Castle
Publikováno v:
Journal of Medicinal Chemistry. 41:1357-1360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2821bb7f749a376a1a2d6c7a50b95408
https://doi.org/10.1021/jm9801049
https://doi.org/10.1021/jm9801049
Autor:
Mariano Busso, Kuo-Chen Chou, W. Gary Tarpley, Kathleen M. Downey, Donna L. Romero, Paul A. Aristoff, Kellie M. Franks, Fritz Reusser, Richelle J. Lemay, Lionel Resnick, Ferenc J. Kezdy, Martin R. Deibel, Irene W. Althaus, Antero G. So, Richard C. Thomas
Publikováno v:
Biochemical Pharmacology. 51:743-750
U-31,355, or 4-amino-2-(benzylthio)-6-chloropyrimidine is an inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and possesses anti-HIV activity in HIV-1-infected lymphocytes grown in tissue culture. The compound acts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82f563ba6cbefcc60245110e81d6d6f
https://doi.org/10.1016/0006-2952(95)02390-9
https://doi.org/10.1016/0006-2952(95)02390-9
Autor:
Suvit Thaisrivongs, Harvey I. Skulnick, Steve R. Turner, Joseph W. Strohbach, Ruben A. Tommasi, Paul D. Johnson, Paul A. Aristoff, Thomas M. Judge, Ronald B. Gammill, Jeanette K. Morris, Karen R. Romines, Robert A. Chrusciel, Roger R. Hinshaw, Kong-Teck Chong, W. Gary Tarpley, Susan M. Poppe, David E. Slade, Janet C. Lynn, Miao-Miao Horng, Paul K. Tomich, Eric P. Seest, Lester A. Dolak, W. Jeffrey Howe, Gina M. Howard, Francis J. Schwende, Lisa N. Toth, Guy E. Padbury, Grace J. Wilson, Lihua Shiou, Gail L. Zipp, Karen F. Wilkinson, Bob D. Rush, Mary J. Ruwart, Kenneth A. Koeplinger, Zhiyang Zhao, Serena Cole, Renee M. Zaya, Thomas J. Kakuk, Musiri N. Janakiraman, Keith D. Watenpaugh
Publikováno v:
Journal of Medicinal Chemistry. 39:4349-4353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7de8a7ff5c653756fe8a0d71028a5b
https://doi.org/10.1021/jm960541s
https://doi.org/10.1021/jm960541s
Autor:
Satish K. Sharma, Kenneth B. Rank, Carol A. Bannow, Joseph W. Leone, Alfredo G. Tomasselli, Donna J. Rothrock, Robert L. Heinrikson, Clark W. Smith, Susan M. Poppe, David B. Evans, Naisheng Fan, W. Gary Tarpley
Publikováno v:
Journal of Biological Chemistry. 270:13573-13579
Active, recombinant p68 reverse transcriptase (RT) from human immunodeficiency virus type 2 (HIV-2), with an NH2-terminal extension containing a hexahisti-dine sequence was isolated from extracts of Escherichia coli by immobilized metal affinity chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0385378507adbac5194e72c348fbaa
https://doi.org/10.1016/s0021-9258(18)92316-1
https://doi.org/10.1016/s0021-9258(18)92316-1
Autor:
Kenneth B. Rank, Satish K. Sharma, Richard C. Thomas, Naisheng Fan, W. Gary Tarpley, David B. Evans
Publikováno v:
FEBS Letters. 359:233-238
Bisheteroarylpiperazines (BHAPs) are highly specific inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). BHAP-resistant HIV-1 is sensitized to other classes of nonnucleoside RT inhibitors and this has been primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2d927f57e77b8b42eea6f7ca56f7b5
https://doi.org/10.1016/0014-5793(95)00051-a
https://doi.org/10.1016/0014-5793(95)00051-a
Publikováno v:
Protein Expression and Purification. 3:126-133
A method for the purification of a truncated, biologically active human immunodeficiency virus type 1 (HIV-1) trans -activator (rTAT) from recombinant Escherichia coli is reported here. The purification steps utilized include mild extraction (French
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4031bf8ff62c9424529cf9b4fdc57a18
https://doi.org/10.1016/s1046-5928(05)80029-4
https://doi.org/10.1016/s1046-5928(05)80029-4
Publikováno v:
Protein Expression and Purification. 2:205-213
A strategy for the purification and cleavage of chimeric recombinant proteins based on a genetically engineered metal-binding peptide and a human renin cleavage site is described. Vectors were constructed to direct the synthesis of chimeric human imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08743d0b895eab1f90a1ee36551a270b
https://doi.org/10.1016/1046-5928(91)90073-r
https://doi.org/10.1016/1046-5928(91)90073-r
Autor:
W. Gary Tarpley, Nancy A. Strakalaitis, Debasish Chattopadhyay, David P. Brunner, H.M. Einspahr, Martin R. Deibel
Publikováno v:
Protein expression and purification. 3(2)
HIV-1 reverse transcriptase (RT) has been successfully expressed as a biologically active recombinant protein in Escherichia coli and purified to homogeneity. After partial purification, RT was obtained primarily in a heterodimeric form represented b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d478ff5d064c9ebc4c6def6edef298
https://pubmed.ncbi.nlm.nih.gov/1384859
https://pubmed.ncbi.nlm.nih.gov/1384859
Publikováno v:
AIDS research and human retroviruses. 6(3)
We engineered a prokaryotic expression vector encoding the HIV reverse transcriptase (RT). We grew Escherichia coli JM109 carrying the vector in a 250-liter stirred tank fermentor and purified RT (p66) under native conditions to apparent homogeneity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860b28aa1c855a493c36907015965f8d
https://pubmed.ncbi.nlm.nih.gov/1692723
https://pubmed.ncbi.nlm.nih.gov/1692723