Zobrazeno 1 - 10
of 40
pro vyhledávání: '"W. G. Tatton"'
Publikováno v:
Pure and Applied Chemistry. 71:2039-2046
In recent years, apoptotic cell death has been implicated with different progressive neurodegenerative diseases such as Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis or Alzheimer's disease. The hypothesis emerged, that a dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6f83d233f000c4c487d7a0d16b4530
https://doi.org/10.1351/pac199971112039
https://doi.org/10.1351/pac199971112039
Autor:
S. L. Shankar, A.C. Cuello, R. M. E. Chalmers-Redman, Moshe Szyf, Susan M. Grant, W. G. Tatton
Publikováno v:
NeuroReport. 10:41-46
Metabolic hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b51ffbc6fee037d1bddcaf9def0c69
https://doi.org/10.1097/00001756-199901180-00008
https://doi.org/10.1097/00001756-199901180-00008
Autor:
W G, Tatton, R M, Chalmers-Redman
Publikováno v:
Neurology. 47:171S-183S
(-)-Deprenyl has been used to irreversibly inhibit monoamine oxidase B (MAO-B) in Parkinson's disease (PD) and Alzheimer's disease (AD) as a possible means of improving dopaminergic neurotransmission or of reducing neuronal necrosis caused by oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9870d03fcb3deae420d109727c54842f
https://doi.org/10.1212/wnl.47.6_suppl_3.171s
https://doi.org/10.1212/wnl.47.6_suppl_3.171s
Publikováno v:
Current Eye Research. 14:119-126
Retinal ganglion cells (RGCs) have been shown to die by apoptosis after damage to their axons caused by optic nerve crush and the death can be reduced by some neurotrophic factors. Since (-)-deprenyl can reduce apoptotic death in some neuronal system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ece38fc0ea77fc2b790d9d019db956
https://doi.org/10.3109/02713689508999923
https://doi.org/10.3109/02713689508999923
Publikováno v:
Journal of Neuroscience Research. 38:64-74
The effect of (–)-deprenyl on the survival of axotomized adult murine facial motoneurons was investigated. Previously, (—)-deprenyl was shown to increase the number of rat facial motoneurons (FMns) surviving after axotomy at postnatal day 14, app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef7b10f68939b2931beaed44b6ea169
https://doi.org/10.1002/jnr.490380109
https://doi.org/10.1002/jnr.490380109
Publikováno v:
Journal of Neuroscience Research. 37:278-286
R(-)-deprenyl has been shown to rescue axotomized immature facial motoneurons with an efficacy comparable to that of the neurotrophic factors CNTF and BDNF (Salo and Tatton, J Neurosci Res 31:394-400, 1992; Ansari et al., J Neurosci 13:4042-4053, 199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d4a647d04289a6ab95662d67adf341
https://doi.org/10.1002/jnr.490370213
https://doi.org/10.1002/jnr.490370213
Publikováno v:
Human brain mapping. 4(1)
Two premovement potentials, the bereitschaftspotential (BP) and negative slope (NS'), can be recorded prior to the execution of self-paced hand movements using back-averaging of scalp electrical recordings. The contributions of the contralateral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d6c5c7139eaf69a8307fffd47fb87ab
https://pubmed.ncbi.nlm.nih.gov/20408183
https://pubmed.ncbi.nlm.nih.gov/20408183
Autor:
W. G. Tatton, P. T. Salo
Publikováno v:
Journal of Neuroscience Research. 31:394-400
Deprenyl, a monoamine oxidase B inhibitor, appears to slow the progression of neurological deficits in Parkinson's disease and cognitive decline in Alzheimer's disease. The mechanisms for the slowing of the diseases are unknown. Deprenyl can reduce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5907b5b35dcfc100fcb238b9234ac70c
https://doi.org/10.1002/jnr.490310223
https://doi.org/10.1002/jnr.490310223
Autor:
W. G. Tatton, C. E. Greenwood
Publikováno v:
Journal of Neuroscience Research. 30:666-672
Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) neurons by inhibiting monoamine oxidase B necessary to mediate the conversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6156f6173b9fa8e9a8bf847e42d0c95f
https://doi.org/10.1002/jnr.490300410
https://doi.org/10.1002/jnr.490300410
Publikováno v:
Magnetic Resonance in Medicine. 15:58-69
This study determines the accuracy and feasibility of using localized spin-lattice (T1) relaxation time measurements from magnetic resonance (MR) images to follow changes in extracellular/intracellular fluid ratios in defined subvolumes of living tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df18810f1e435305fcc555fddd1c519a
https://doi.org/10.1002/mrm.1910150107
https://doi.org/10.1002/mrm.1910150107