Zobrazeno 1 - 10
of 78
pro vyhledávání: '"W. G. Laver"'
Publikováno v:
Immunology today. 3(10)
The influenza virus behaves unpredictably and can cause devastating pandemics. Nearly 50 years after its first isolation it is probably the most infectious agent known that we cannot yet control. Why? The answer lies in the virus's unique capacity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c7fce8d07f949e57e9c58204045c64
https://pubmed.ncbi.nlm.nih.gov/25290224
https://pubmed.ncbi.nlm.nih.gov/25290224
Autor:
W. Lew, S Swaminathan, Raymond C. Stevens, Min Chen, C. Y. Tai, N Bischofberger, Lijun Zhang, W. G. Laver, Hua-Kun Liu, M.A. Williams, C U Kim, D. B. Mendel
Publikováno v:
Journal of the American Chemical Society. 119:681-690
The design, synthesis, and in vitro evaluation of the novel carbocycles as transition-state-based inhibitors of influenza neuraminidase (NA) are described. The double bond position in the carbocyclic analogues plays an important role in NA inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e916cab1b14a27816c0b34b423e9882
https://doi.org/10.1021/ja963036t
https://doi.org/10.1021/ja963036t
Autor:
W Visser, C J O Dudfield, I L Whyte, V Karthigeyan, B L Smith, M J Corcoran, J F A Lang, H M Williams, P M B Fish, M G Brown, R Goodfellow, W G Laver, Jacobs, R C Dyer, Ec Hambly, P M Blair Fish
Publikováno v:
Proceedings of the Institution of Civil Engineers - Civil Engineering. 102:179-182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b4005eb487725755fcb5ab53be1e83
https://doi.org/10.1680/icien.1994.27252
https://doi.org/10.1680/icien.1994.27252
Autor:
Matthew A. Williams, Raymond C. Stevens, S. Swaminathan, Norbert Bischofberger, Choung U. Kim, C. Y. Tai, Hua-Kun Liu, Willard Lew, Lijun Zhang, Dirk B. Mendel, W. G. Laver, Min Chen
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825f901d819d7b7aee3d8ddbd7a20a9b
https://doi.org/10.1002/chin.199719227
https://doi.org/10.1002/chin.199719227
Publikováno v:
Journal of Virology. 66:7597-7600
We isolated, purified, and characterized the hemagglutinin-neuraminidase (HN) of human parainfluenza virus type 1, with the ultimate goal of producing crystals suitable for three-dimensional X-ray structure analysis. Pronase was used to cleave the gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618d0da5604cef26725b87f33f2f35aa
https://doi.org/10.1128/jvi.66.12.7597-7600.1992
https://doi.org/10.1128/jvi.66.12.7597-7600.1992
Autor:
W G Laver
Publikováno v:
Proceedings of the Institution of Civil Engineers - Civil Engineering. 92:116-126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9e23501f258c23692db44a41228531
https://doi.org/10.1680/icien.1992.20281
https://doi.org/10.1680/icien.1992.20281
Publikováno v:
Proceedings of the National Academy of Sciences. 87:3884-3888
Influenza B viruses evolve more slowly than human influenza A, but no reasons for the difference have been established. We have analyzed sequence changes in the hemagglutinin and neuraminidase of influenza B viruses (and have determined four hemagglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323ae370b3508e7021d82a6c88049b68
https://doi.org/10.1073/pnas.87.10.3884
https://doi.org/10.1073/pnas.87.10.3884
Autor:
Hing L. Sham, Gentles R, Kent D. Stewart, Dale J. Kempf, Warren M. Kati, Gary T. Wang, W. G. Laver, Steven W. Muchmore, Giranda, Thomas J. Sowin, Yuanwei Chen, S. Wang
Publikováno v:
Journal of medicinal chemistry. 44(8)
The discovery of (+/-)-(2S,3R,4R)-2-(trifluoroacetamido)methyl-3-amino-1-(N'-ethyl-N'-isopropylcarbamyl)pyrrolidine-4-carboxylic acid (A-192558, 20e) as a potent inhibitor of influenza neuraminidase (NA) is described. Efficient syntheses of two core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39e0a554c0c0a52edd58226ac8d60fd
https://pubmed.ncbi.nlm.nih.gov/11312919
https://pubmed.ncbi.nlm.nih.gov/11312919
Autor:
Raymond C. Stevens, W. Lew, Lijun Zhang, Huiwei Wu, D. B. Mendel, Xiaowu Chen, W. G. Laver, Choung U. Kim, M.A. Williams, Paul A. Escarpe
Publikováno v:
Journal of medicinal chemistry. 41(14)
A series of influenza neuraminidase inhibitors with the cyclohexene scaffold containing lipophilic side chains have been synthesized and evaluated for influenza A and B neuraminidase inhibitory activity. The size and geometry of side chains have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06242f5cb50bcc9eefebede36dec59d
https://pubmed.ncbi.nlm.nih.gov/9651151
https://pubmed.ncbi.nlm.nih.gov/9651151
Autor:
E A, Sudbeck, M J, Jedrzejas, S, Singh, W J, Brouillette, G M, Air, W G, Laver, Y S, Babu, S, Bantia, P, Chand, N, Chu, J A, Montgomery, D A, Walsh, M, Luo
Publikováno v:
Journal of molecular biology. 267(3)
The active site of influenza virus neuraminidase (NA) is formed by 11 universally conserved residues. A guanidino group incorporated into two unrelated NA inhibitors was previously reported to occupy different negatively charged sites in the NA activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3f8c8b4e93668aa041d138f6011998e
https://pubmed.ncbi.nlm.nih.gov/9126840
https://pubmed.ncbi.nlm.nih.gov/9126840