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Akademický článek

Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis

Autor: Bayli DiVita Dean, Tyler Wildes, Joseph Dean, Oleg Yegorov, Changlin Yang, David Shin, Connor Francis, John W Figg, Mathew Sebastian, Laura Falceto Font, Dan Jin, Alexandra Reid, Ginger Moore, Brandon Fernandez, Brandon Wummer, Carmelle Kuizon, Duane Mitchell, Catherine T Flores

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)

Background Glioma-induced immune dysregulation of the hematopoietic system has been described in a limited number of studies. In this study, our group further demonstrates that gliomas interrupt the cellular differentiation programming and outcomes o

Externí odkaz: https://doaj.org/article/ffbff475bf724a8eb19c4268e79f2c00

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The current landscape of immunotherapy for pediatric brain tumors

Autor: Eugene I. Hwang, Elias J. Sayour, Catherine T. Flores, Gerald Grant, Robert Wechsler-Reya, Lan B. Hoang-Minh, Mark W. Kieran, Joanne Salcido, Robert M. Prins, John W. Figg, Michael Platten, Kate M. Candelario, Paul G. Hale, Jason E. Blatt, Lance S. Governale, Hideho Okada, Duane A. Mitchell, Ian F. Pollack

Publikováno v: Nature Cancer. 3:11-24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8e627d90014cfa20ed8251f0efa8b34
https://doi.org/10.1038/s43018-021-00319-0

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Proteinopathies and Neurotrauma: Update on Degenerative Cascades

Autor: Stephan, Quintin, Zachary A, Sorrentino, Yusuf, Mehkri, Sai, Sriram, Sydney, Weisman, Caroline Grace, Davidson, Grace M, Lloyd, Eric, Sung, John W, Figg, Brandon, Lucke-Wold

Publikováno v: JSM Neurosurg Spine

Neurotrauma, especially repetitive neurotrauma, is associated with the development of progressive neurodegeneration leading to chronic traumatic encephalopathy (CTE). Exposure to neurotrauma regularly occurs during sports and military service, often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a33298586ef7739b420b720a3b49bc8
https://pubmed.ncbi.nlm.nih.gov/36466377

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Akademický článek

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Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia

Autor: Juan Martin Barajas, John W Figg, Esther A. Obeng

Publikováno v: Current opinion in hematology. 28(2)

Purpose of review Mutations in components of the spliceosome are the most common acquired lesions in myelodysplastic syndromes (MDS) and are frequently identified in other myeloid malignancies with a high rate of progression to acute myeloid leukemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9448c08fd4110c4bad1286bc375ff841
https://pubmed.ncbi.nlm.nih.gov/33492002

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The current landscape of immunotherapy for pediatric brain tumors

Autor: Eugene I, Hwang, Elias J, Sayour, Catherine T, Flores, Gerald, Grant, Robert, Wechsler-Reya, Lan B, Hoang-Minh, Mark W, Kieran, Joanne, Salcido, Robert M, Prins, John W, Figg, Michael, Platten, Kate M, Candelario, Paul G, Hale, Jason E, Blatt, Lance S, Governale, Hideho, Okada, Duane A, Mitchell, Ian F, Pollack

Publikováno v: Nature cancer. 3(1)

Pediatric central nervous system tumors are the most common solid malignancies in childhood, and aggressive therapy often leads to long-term sequelae in survivors, making these tumors challenging to treat. Immunotherapy has revolutionized prospects f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a8f2fb0da26e39cff5f51bb0f45053d
https://pubmed.ncbi.nlm.nih.gov/35121998

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Chronic sleep restriction increases soluble hippocampal Aβ-42 and impairs cognitive performance

Autor: Gary W. Boehm, John W. Figg, Christopher W. Hagen, Julia L. Peterman, Paige N. Braden, Kelly Brice, Michael J. Chumley

Publikováno v: Physiologybehavior. 226

Currently, over 44 million people worldwide suffer from Alzheimer's disease (AD). A common feature of AD is disrupted sleep. Sleep is essential for many psychological and physiological functions, though 35.3% of adults report getting less than 7 hour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5addad0ae2d2595276ad457a4566f5
https://pubmed.ncbi.nlm.nih.gov/32791178

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Akademický článek

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