Zobrazeno 1 - 10
of 252
pro vyhledávání: '"W. Feniuk"'
Publikováno v:
Cephalalgia. 22:260-264
The purpose of this study was to use intravital microscopy to determine the effect of a selective adenosine A1 receptor agonist, GR79236 (1, 3 and 10 microg/kg i.v.), on neurogenic dural blood vessel dilation in anaesthetized rats. Vasodilation was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ce7fb5415d819f7fb705590f7d707e
https://doi.org/10.1046/j.1468-2982.2002.00345.x
https://doi.org/10.1046/j.1468-2982.2002.00345.x
Publikováno v:
Neuropharmacology. 34:377-382
The involvement of 5-HT1D receptors in the regulation of 5-HT release in the guinea-pig brain was examined using the novel 5-HT1D receptor blocking drug GR127935. Levels of 5-HT were measured in frontal cortex of anaesthetized guinea-pigs using micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71a674d1944adf71ea6919af028b58c
https://doi.org/10.1016/0028-3908(94)00167-q
https://doi.org/10.1016/0028-3908(94)00167-q
Publikováno v:
Journal of psychopharmacology (Oxford, England). 5(3)
The preferential 5-HT 2/5-HT1C receptor agonist DOI (0.1-4 mg/kg s.c.) caused an increase in locomotor activity, grooming and 'wet-dog' shakes (WDS) in the adult guinea-pig. The DOI-induced WDS behaviour was potently inhibited by several antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a427cb0d07f78e3d204df2d2d5e3a7b2
https://pubmed.ncbi.nlm.nih.gov/22282555
https://pubmed.ncbi.nlm.nih.gov/22282555
Publikováno v:
Journal of Psychopharmacology. 8:14-21
The 5-HT1 receptor agonist GR46611 (3-30 mg/kg s.c.) caused a dose-related decrease in rectal temperature in the adult guinea-pig. A lower dose (20 μg) administered directly into the lateral cerebral ventricle also caused a hypothermic response, sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c2c88301f849c1cd2d04101425655e
https://doi.org/10.1177/026988119400800103
https://doi.org/10.1177/026988119400800103
Publikováno v:
Trends in cardiovascular medicine. 1(5)
Serotonin is widely distributed throughout the body, can have potent and profound effects on the cardiovascular system, and may be involved in the pathophysiology of several cardiovascular disease states. Recent advances in the classification of sero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82f4c143ed46b7a3508ae74a69d5e10d
https://pubmed.ncbi.nlm.nih.gov/21239312
https://pubmed.ncbi.nlm.nih.gov/21239312
Autor:
W. Feniuk, David I. C. Scopes, A.W. Oxford, W. L. Mitchell, Guy A. Higgins, H. A. Kelly, M. Skingle, M.B. Tyers, I. B. Campbell, C. C. Jordan, Alan H. Wadsworth, M. C. Carter, J. W. Clitherow, Eric W. Collington, Helen E. Connor, D. T. Beattie
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530f04a40209f7748934390768bfb9ab
https://doi.org/10.1002/chin.199451138
https://doi.org/10.1002/chin.199451138
Publikováno v:
European Journal of Pharmacology. 197:113-116
The putative 5-HT1A receptor antagonist BMY 7378 (3-100 micrograms.kg-1 i.v.) caused reductions in blood pressure, heart rate and efferent renal nerve activity in anaesthetised cats. Similar effects were produced by the selective 5-HT1A receptor agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eee153aeaed644155b13208bd304819
https://doi.org/10.1016/0014-2999(91)90373-x
https://doi.org/10.1016/0014-2999(91)90373-x
Autor:
M.R. Jackson, Oliver N. Keene, R.J.N. Tanner, J.C.C Talbot, C.A. Endersby, W. Feniuk, Patrick P.A. Humphrey, V. Pfaffenrath, A.J. Pilgrim, N.S. Baber, LF Lacey, J.W. Lance, A.S. Marriott, E.G. Brown, R.N. Smith, M.L. Tucker, P.A. Fowler, M. Thomas
Publikováno v:
European Neurology. 31:300-305
Three oral doses of sumatriptan, 100, 200 and 300 mg, given as dispersible tablets, were compared in the acute treatment of migraine in a double-blind, placebo-controlled, parallel-group study of 1,13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb403998d99a6acef00f61d0ea6c82e
https://doi.org/10.1159/000116632
https://doi.org/10.1159/000116632
Autor:
Patrick P.A. Humphrey, M.L. Tucker, J.W. Lance, M.R. Jackson, V. Pfaffenrath, Oliver N. Keene, R.N. Smith, R.J.N. Tanner, P.A. Fowler, M. Thomas, W. Feniuk, A.S. Marriott, E.G. Brown, L.F. Lacey, A.J. Pilgrim, J.C.C Talbot, N.S. Baber, C.A. Endersby
Publikováno v:
European Neurology. 31:332-338
A double-blind, randomized, multicentre, parallel-group study was carried out to compare intranasal sumatriptan with placebo in the treatment of migraine. Seventy-four patients (37 in each treatment group) were recruited into the study. Patients rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781083884b0573bc35331d01312d5f0f
https://doi.org/10.1159/000116761
https://doi.org/10.1159/000116761
Autor:
M.R. Jackson, Oliver N. Keene, R.J.N. Tanner, W. Feniuk, V. Pfaffenrath, LF Lacey, R.N. Smith, J.C.C Talbot, P.A. Fowler, J.W. Lance, C.A. Endersby, M. Thomas, Patrick P.A. Humphrey, A.S. Marriott, E.G. Brown, A.J. Pilgrim, M.L. Tucker, N.S. Baber
Publikováno v:
European Neurology. 31:323-331
The efficacy and safety of sumatriptan, a selective 5-HT1 like receptor agonist, were studied in a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe313cc4f76314028104b00f46e820d
https://doi.org/10.1159/000116760
https://doi.org/10.1159/000116760