Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Autor: A. SILVESTRI, F. VICENTE, M. VICENT, B. STECHMANN, W. FECKE

Publikováno v: DRUG DISCOVERY TODAY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Universitat Rovira i virgili (URV)

The success of preclinical drug discovery strongly relies on the ability of experimental models to resemble human pathophysiology. The number of compounds receiving approval for clinical use is limited, and this has led to the development of more phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::359b78c7dff1cb085b5ff634eb12e189
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3778

Protection of hDAF-transgenic porcine endothelial cells against activation by human complement: role of the membrane attack complex

Autor: Joanna Long, Andrew Richards, Richard A. Harrison, W. Fecke

Publikováno v: Xenotransplantation. 9:97-105

Xenograft rejection in the discordant pig-to-primate model is dependent on binding of natural antibodies to gal-alpha [1-3]-gal epitopes on the porcine endothelial cell (EC). This leads to complement activation and deposition of activation products o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29f45ebd3f95a317a2c6d047c766abe5
https://doi.org/10.1034/j.1399-3089.2002.1o012.x

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An antisense RNA expression vector for Neurospora crassa

Autor: W. Fecke, U. Nehls, H. Weis

Publikováno v: Fungal Genetics Reports. 40:34-35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c29e381d9f338c51cd58ff487ff849b3
https://doi.org/10.4148/1941-4765.1400