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In vivo modulation of ventral tegmental area dopamine and glutamate efflux by local GABAB receptors is altered after repeated amphetamine treatment

Autor: Marco Giorgetti, Marina E. Wolf, W Froestl, Gregory Hotsenpiller

Publikováno v: Neuroscience. 109:585-595

The activity of dopamine neurons in the ventral tegmental area is modulated by excitatory (glutamatergic) and inhibitory (GABAergic) afferents. GABA, released by intrinsic neurons and by projection neurons originating in the nucleus accumbens and oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520c5cc184da57ebf1bd075d5178607b
https://doi.org/10.1016/s0306-4522(01)00510-3

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Determination of the GABAB receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectrometry

Autor: W Froestl, Philippe Ramstein, Jürgen Kühnöl, Sandrine Desrayaud, Reiner Aichholz, Wolfgang Blum

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 748:349-359

An assay, based on pre-column derivatization and micro-high-performance liquid chromatography-tandem mass spectrometry, was developed for the determination of the GABA(B) agonist CGP 44532 in rat plasma. CGP 44532, a highly polar 3-amino-2(S)-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730f5ca615ab9e14148764192f4b56f5
https://doi.org/10.1016/s0378-4347(00)00352-2

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Distribution and properties of GABAB antagonist [3H]CGP 62349 binding in the rhesus monkey thalamus and basal ganglia and the influence of lesions in the reticular thalamic nucleus

Autor: W Froestl, Norman G. Bowery, A.V Ambardekar, Kristy Kultas-Ilinsky, Igor A. Ilinsky

Publikováno v: Neuroscience. 93:1339-1347

GABA(B) receptors are believed to be associated with the efferents of the nucleus reticularis thalami, which is implicated in the regulation of activity in the thalamocortical-corticothalamic circuit and plays a role in absence seizures. Yet, the dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6bf46ed4f66e7de02e4327617a6bd4
https://doi.org/10.1016/s0306-4522(99)00282-1

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The GABA B receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice

Autor: J M, Wierońska, M, Kusek, K, Tokarski, J, Wabno, W, Froestl, A, Pilc

Publikováno v: British journal of pharmacology. 163(5)

An important role of GABAergic neurotransmission in schizophrenia was proposed a long time ago, but there is limited data to support this hypothesis. In the present study we decided to investigate GABA(B) receptor ligands in animal models predictive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::344b866b808aaaae6c0a2b0172813bae
https://pubmed.ncbi.nlm.nih.gov/21371011

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Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase

Autor: K M, Gibson, D S M, Schor, M, Gupta, W S, Guerand, H, Senephansiri, T G, Burlingame, H, Bartels, B M, Hogema, T, Bottiglieri, W, Froestl, O C, Snead, M, Grompe, C, Jakobs

Publikováno v: Journal of neurochemistry. 81(1)

Metabolite profiling in succinate semialdehyde dehydrogenase (SSADH; Aldh5a1-/-) deficient mice previously revealed elevated gamma-hydroxybutyrate (GHB) and total GABA in urine and total brain and liver extracts. In this study, we extend our metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9323386c4bd42c564228a03fcaecd6fd
https://pubmed.ncbi.nlm.nih.gov/12067239

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Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

Autor: S, Urwyler, J, Mosbacher, K, Lingenhoehl, J, Heid, K, Hofstetter, W, Froestl, B, Bettler, K, Kaupmann

Publikováno v: Molecular pharmacology. 60(5)

The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of gamma-aminobutyric acid(B) (GABA(B)) receptor function. They potentiate GABA-stimulated guanosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5645d19a326abbdf99f3f3daa0088e11
https://pubmed.ncbi.nlm.nih.gov/11641414

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Ligands for the isolation of GABA(B) receptors [corrected]

Autor: W, Froestl, B, Bettler, H, Bittiger, J, Heid, K, Kaupmann, S J, Mickel, D, Strub

Publikováno v: Neuropharmacology. 38(11)

Since the discovery that the most abundant inhibitory neurotransmitter in the mammalian brain, GABA (gamma-aminobutyric acid), interacts not only with ionotropic GABA(A) receptors, but also with metabotropic GABA(B) receptors (Bowery et al., 1980) mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d020510128708f397dffdc15f54660a9
https://pubmed.ncbi.nlm.nih.gov/10587079

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Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists

Autor: M, Chebib, R J, Vandenberg, W, Froestl, G A, Johnston

Publikováno v: European journal of pharmacology. 329(2-3)

The phosphinic and methylphosphinic analogues of gamma-aminobutyric acid (GABA) are potent GABA(C) receptor antagonists but are even more potent as GABA(B) receptor agonists. Conformationally restricted unsaturated phosphinic and methylphosphinic ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e171e110011c76c52dc5721219cd642
https://pubmed.ncbi.nlm.nih.gov/9226416

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