Leveraging lessons learned to prevent future disasters—insights from the 2013 Colombia-US binational exchange

Autor: Marci Scott, Jorge Ivan Quintero, Zane Gibson, Frances Burkhart, Robert Allen, Gloria Patricia Cortés, Jaime Andres Gallego, Andrew B. Lockhart, John Schelling, Jacqueline Montoya, Scott Beason, Felix Ricardo Giraldo, Daniel Banks, John W. Ewert, Harold Trujillo Bocanegra, Kyle Bustad, Marta Calvache, Eduardo Rodriguez, Carolyn L. Driedger, Cesar Gutierrez

Publikováno v: Journal of Applied Volcanology, Vol 9, Iss 1, Pp 1-21 (2020)

In 2013, scientists implemented a binational exchange for emergency planners and responders in communities near Nevado del Ruiz in Colombia and volcanoes of the Cascade Range of the United States (US). This program was designed to promote understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7608ddc3274f6c22fcfbccfe82767107
http://link.springer.com/article/10.1186/s13617-019-0090-8

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

Autor: Arwen R. Pearson, N. Ullah, Christian Betzel, M. Groessler, M. Galchenkova, Huijong Han, Winfried Hinrichs, Sebastian Guenther, Philipp Middendorf, Sven Falke, Hévila Brognaro, Markus Perbandt, L. Brings, Janina Sprenger, J. Lieske, Angelica Luana C Barra, Rafael Rahal Guaragna Machado, Kristina Lorenzen, Faisal H. M. Koua, Carsten Wrenger, Thomas J. Lane, Vasundara Srinivasan, Edmarci Elisa de Souza, Bruno Alves Franca, Patrick Y. A. Reinke, Alke Meents, J. Hakanpaeae, Prince Rajaiah Prabhu, M. Domaracky, Edison Luiz Durigon, Oleksandr Yefanov, F. Trost, Dušan Turk, H. Andaleeb, Danielle Bruna Leal Oliveira, Markus Wolf, M. Wang, Helen M. Ginn, Robin Schubert, W. Ewert, M. Schwinzer, N. Werner, C. Schmidt, Sofiane Saouane, Henry N. Chapman, Erika Donizette Candido, Luca Gelisio

SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, PLpro has the additional and vital function of removing ubiquitin and ISG15 (Interferon-stimulated gene 15) from host-cell proteins to aid coron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::964928cd6675bbfb565ecc660007aa33
https://doi.org/10.1101/2021.11.17.468943

Natural Resource Management

Autor: Alan W. Ewert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe371b69a63deb8e48cf726c4383577a
https://doi.org/10.4324/9780429039706

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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Autor: M. Schwinzer, Faisal Hammad Mekky Koua, Ashwin Chari, J. Lieske, Maria Garcia-Alai, Gleb Bourenkov, Russell J. Cox, Salah Awel, W. Ewert, Dušan Turk, Luca Gelisio, N. Werner, Hévila Brognaro, J. Pletzer-Zelgert, Juraj Knoska, Arwen R. Pearson, D. Melo, Matthias Rarey, Ilona Dunkel, Boris Krichel, Y. Gevorkov, A. Tolstikova, David von Stetten, Eike C. Schulz, Andrea Zaliani, Winfried Hinrichs, F. Trost, Helen M. Ginn, Xinyuanyuan Sun, Stephan Niebling, Holger Fleckenstein, Aleksandra Usenik, J. Wollenhaupt, Robin Schubert, Stephan Günther, Kristina Lorenzen, J. Boger, P. Reinke, Diana C. F. Monteiro, Bruno Alves Franca, Isabel Bento, Manfred S. Weiss, Ariana Peck, Dominik Oberthuer, Pedram Mehrabi, Pontus Fischer, Sebastian Günther, Jure Loboda, P. Lourdu Xavier, C. Schmidt, Christian Betzel, Huijong Han, N. Ullah, Philip Gribbon, Aida Rahmani Mashhour, Charlotte Uetrecht, Guillaume Pompidor, Christiane Ehrt, Christian G. Feiler, Saravanan Panneerselvam, Bernhard Ellinger, Christian M. Günther, Thomas J. Lane, Linlin Zhang, S. Meier, Tobias Beck, Henry N. Chapman, M. Domaracky, Sven Falke, Katarina Karničar, Markus Wolf, Cromarte Rogers, S. Saouane, Ivars Karpics, Rolf Hilgenfeld, Gisel E. Peña-Murillo, Vasundara Srinivasan, Alke Meents, Miriam Barthelmess, M. Galchenkova, B. Seychell, Beatriz Escudero-Pérez, Thomas A. White, Janine-Denise Kopicki, Joanna J. Zaitseva-Doyle, W. Brehm, M. Groessler, Brenna Norton-Baker, Frank Schlünzen, Chufeng Li, Henning Tidow, Maria Kuzikov, Andrea R. Beccari, Johanna Hakanpää, Henry Gieseler, Yaiza Fernández-García, Oleksandr Yefanov, Thomas R. Schneider, Anna Hänle, Jan Meyer, H. Andaleeb, V. Hennicke

Publikováno v: Science (New York, N.y.)
Science 372 (6542): 642-646 (2021-05-07)
Science
Science / Science now 372(6542), 642-646 (2021). doi:10.1126/science.abf7945

A large-scale screen to target SARS-CoV-2 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome is initially expressed as two large polyproteins. Its main protease, Mpro, is essential to yield functional viral proteins, making it a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7f9ac410aabd144f9e9014ed83aff5
https://resolver.caltech.edu/CaltechAUTHORS:20201113-100151878