Zobrazeno 1 - 10
of 47
pro vyhledávání: '"W. E. Gutteridge"'
Autor:
W E Gutteridge
Publikováno v:
Parasitology. 114:145-151
New chemotherapies are urgently needed for the parasitic infections of animals and for the tropical diseases of man. Rational molecular design approaches to attempt to discover such products require a massive investment of resources up-front of actua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c27dbc2d57eef4b0911ea8667e69fb7
https://doi.org/10.1017/s0031182097008998
https://doi.org/10.1017/s0031182097008998
Autor:
D. C. Jenkins, D. D. Miller, J. P. Court, R. Thornton, W. E. Gutteridge, J. C. W. Comley, R. H. Nicol, Hudson Alan Thomas, J. N. Stables, A. W. Randall
Publikováno v:
European Journal of Medicinal Chemistry. 27:503-509
Structure activity studies against filariae are described for a series of derivatives of 6-(3-aminophenyl)-2,3,5,6-tetrahydroimidazo[2,1- b ]thiazole ( 15 derivatives. In an in vivo assay using gerbils implanted with both Acanthocheilonema viteae and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2bc6a511750da1429ae41170b940ff
https://doi.org/10.1016/0223-5234(92)90184-3
https://doi.org/10.1016/0223-5234(92)90184-3
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:225-228
The efficacy of a new class of drugs for Pneumocystis carinii pneumonitis was demonstrated. 566C80, a hydroxynaphthoquinone, administered orally in a dose of greater than or equal to 100 mg/kg of body weight per day prophylactically prevented P. cari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb6a1d6660237c7cd58e91025c77e5e
https://doi.org/10.1128/aac.34.2.225
https://doi.org/10.1128/aac.34.2.225
Autor:
W E, Gutteridge
Publikováno v:
Parassitologia. 41(1-3)
In the absence of vaccines, new chemotherapies are needed urgently to help in the prevention and control of malaria. A number of strategies are being followed world-wide in attempts to discover and develop them: (a) resurrecting 'forgotten' molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58bc3a9805ffb5ab4a63d788d39b1181
https://pubmed.ncbi.nlm.nih.gov/10697901
https://pubmed.ncbi.nlm.nih.gov/10697901
Autor:
W E, Gutteridge
Publikováno v:
Parasitology.
New chemotherapies are urgently needed for the parasitic infections of animals and for the tropical diseases of man. Rational molecular design approaches to attempt to discover such products require a massive investment of resources upfront of actual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::779f997848e84c6e824c931b2e3bcb50
https://pubmed.ncbi.nlm.nih.gov/9309776
https://pubmed.ncbi.nlm.nih.gov/9309776
Autor:
W E, Gutteridge
Publikováno v:
The Journal of protozoology. 38(6)
Hydroxynaphthoquinone 566C80 was synthesised and initially developed as an antimalarial with potent activity against drug-resistant strains of the human malaria parasite, Plasmodium falciparum. Subsequent studies have revealed that in addition, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ab9db8c44a427260a08f981498032cd
https://pubmed.ncbi.nlm.nih.gov/1818143
https://pubmed.ncbi.nlm.nih.gov/1818143
Autor:
A T, Hudson, M, Dickins, C D, Ginger, W E, Gutteridge, T, Holdich, D B, Hutchinson, M, Pudney, A W, Randall, V S, Latter
Publikováno v:
Drugs under experimental and clinical research. 17(9)
566C80 is a novel hydroxynaphthoquinone with broad-spectrum anti-parasitic properties. In vitro the compound was more potent against Plasmodium falciparum than any of the established anti-malarial drugs. It had good activity against the pathogen in A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9002d32b5fb30091640bc9de4f4f59e0
https://pubmed.ncbi.nlm.nih.gov/1822435
https://pubmed.ncbi.nlm.nih.gov/1822435
Publikováno v:
Biochemistry international. 20(2)
Trypanosoma brucei cytoplasm contained a UMP-incorporating activity which was dependent upon the presence of endogenous RNA, stimulated by exogenous RNA and precipitable by ammonium sulphate. The activity cosedimented with ribosomes, and after riboso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30671894d6053df5f6db7742ee2b00b3
https://pubmed.ncbi.nlm.nih.gov/1690540
https://pubmed.ncbi.nlm.nih.gov/1690540
Publikováno v:
Acta Leidensia. 59(1-2)
The primary objective of the Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project, which began in July 1982, was the discovery and development of a safe and effective macrofilaricide for the treatment of onchocerciasis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3334633fa1bdac16d1000fcecc6866f
https://pubmed.ncbi.nlm.nih.gov/2198758
https://pubmed.ncbi.nlm.nih.gov/2198758