Výsledky vyhledávání - "W. E. Biddison"

Chemokine and matrix metalloproteinase secretion by myelin proteolipid protein-specific CD8+ T cells: potential roles in inflammation

Autor: W E Biddison, D D Taub, W W Cruikshank, D M Center, E W Connor, K Honma

Publikováno v: The Journal of Immunology. 158:3046-3053

The demyelination process that occurs in the central nervous system of patients with multiple sclerosis (MS) is, in part, due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. Although many studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74dd01fb5fa5b7ce4a0fac60c2a4934f
https://doi.org/10.4049/jimmunol.158.7.3046

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Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2

Autor: D N Garboczi, U Utz, P Ghosh, A Seth, J Kim, E A VanTienhoven, W E Biddison, D C Wiley

Publikováno v: The Journal of Immunology. 157:5403-5410

T lymphocytes use TCR-alphabeta to bind and to recognize complexes of antigenic peptides bound to MHC proteins located at the surface of APCs. We have assembled and crystallized this intercellular complex of TCR/peptide/MHC from soluble human TCR-alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a484674e03b518be7de846f184a640b
https://doi.org/10.4049/jimmunol.157.12.5403

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Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion

Autor: Steven Jacobson, D Banks, W E Biddison, U Utz

Publikováno v: Journal of Virology. 70:843-851

Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neurological disease characterized by marked degeneration of the spinal cord and the presence of antibodies against HTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2b9a79eb9864a09c9e3012614ffa09
https://doi.org/10.1128/jvi.70.2.843-851.1996

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Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106

Autor: R Martin, U Utz, J E Coligan, J R Richert, M Flerlage, E Robinson, R Stone, W E Biddison, D E McFarlin, H F McFarland

Publikováno v: The Journal of Immunology. 148:1359-1366

Multiple sclerosis (MS), a human demyelinating disease, is thought to be caused by an autoimmunologic process, and myelin basic protein (MBP) is considered a likely autoantigen. Studies of T cell lines (TCL) responding to different parts of the MBP m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f58e7ca1b7a4d682045a2f3dd83b52b
https://doi.org/10.4049/jimmunol.148.5.1359

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Overlapping epitopes that are recognized by CD8+ HLA class I-restricted and CD4+ class II-restricted cytotoxic T lymphocytes are contained within an influenza nucleoprotein peptide

Autor: B M Carreno, R V Turner, W E Biddison, J E Coligan

Publikováno v: The Journal of Immunology. 148:894-899

Viral epitopes that are recognized by both HLA class I-restricted and class II-restricted T cells have been defined for a type A influenza virus nucleoprotein (NP) peptide. CD8+ and CD4+ CTL lines have been generated against a synthetic peptide encom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89ef4834ecf7e68fe6f9e04a71d1d532
https://doi.org/10.4049/jimmunol.148.3.894

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Endogenous loading of HLA-A2 molecules with an analog of the influenza virus matrix protein-derived peptide and its inhibition by an exogenous peptide antagonist

Autor: M C Gammon, M A Bednarek, W E Biddison, S S Bondy, J D Hermes, G E Mark, A R Williamson, H J Zweerink

Publikováno v: The Journal of Immunology. 148:7-12

Episomal plasmids (p8901) with minigenes coding for the influenza virus matrix peptide amino acids 57-68 (KGILGFVFTLTV; referred to as M57-68) or coding for a modified peptide were introduced into HLA-A2-positive target cells. The association of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae6e652db52c91188f46ba35febce5b6
https://doi.org/10.4049/jimmunol.148.1.7

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The 45 pocket of HLA-A2.1 plays a role in presentation of influenza virus matrix peptide and alloantigens

Autor: C C Winter, B M Carreno, R V Turner, S Koenig, W E Biddison

Publikováno v: The Journal of Immunology. 146:3508-3512

Amino acid substitutions were introduced into the 45 pocket of HLA-A2.1 to determine the potential role of this structurally defined feature of class I molecules in viral peptide and alloantigen presentation. The 45 pocket lies below the alpha 1-doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a7d80592a42ff6acefe92ba305078db
https://doi.org/10.4049/jimmunol.146.10.3508

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Measurement of polyclonal and antigen-specific cytotoxic T cell function

Autor: W E, Biddison, R, Lichtenfels, M, Adibzadeh, R, Martin

Publikováno v: Current protocols in immunology.

Measurement of in vitro cytotoxic function of human T cells can be accomplished by polyclonal stimulation of T cell effectors using anti-CD3 antibody, which stimulates all cytolytic effector cells, or with a specific stimulating antigen. Accordingly,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::616c87781eb980bddfd13d58f3be1049
https://pubmed.ncbi.nlm.nih.gov/18432831

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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling

Autor: B M, Baker, S J, Gagnon, W E, Biddison, D C, Wiley

Publikováno v: Immunity. 13(4)

The structure of the A6 alphabetaTCR/HTLV-1 Tax-peptide/MHC I complex with proline 6 of Tax substituted with alanine (P6A), an antagonist, is nearly identical to the structure with wild-type Tax agonist. Neither the proline in the agonist nor the ala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da6215578d450394528ec1e0588e0ef4
https://pubmed.ncbi.nlm.nih.gov/11070166

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