The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases

Autor: Xiangguang Shi, Yahui Chen, Mengkun Shi, Fei Gao, Lihao Huang, Wei Wang, Dong Wei, Chenyi Shi, Yuexin Yu, Xueyi Xia, Nana Song, Xiaofeng Chen, Jörg H. W. Distler, Chenqi Lu, Jingyu Chen, Jiucun Wang

Publikováno v: Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-19 (2024)

Abstract Pulmonary fibrosis (PF) is a severe pulmonary disease with limited available therapeutic choices. Recent evidence increasingly points to abnormal lipid metabolism as a critical factor in PF pathogenesis. Our latest research identifies the dy

Externí odkaz: https://doaj.org/article/4d9bf9c18f6f41499b6b70bf0e68e597

Autologous hematopoietic stem cell transplantation improves long-term survival—data from a national registry

Autor: Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkötter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyßer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Jörg Henes, on behalf of the German Network for Systemic Sclerosis

Publikováno v: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-10 (2022)

Abstract Background Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc. Objectives To assess the safet

Externí odkaz: https://doaj.org/article/6ec913da57ed47739231cbf489c0fd42

Sustained agreement rates in the longitudinal assessment of lupus patients to a Broad Consent for personal data and specimen usage in the RHINEVIT biobank

Autor: Jutta G. Richter, Tim Filla, Hasan Acar, Ellen Bleck, Anna Kernder, Christina Düsing, Stefan Vordenbäumen, Markus Schröder, Ralf Hansen, Jörg H. W. Distler, Matthias Schneider

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

BackgroundBiobanks are essential structures for scientific research. The RHINEVIT biobank is used to recruit biomaterials from rheumatology patients in outpatient care and to conduct clinical research studies (e.g., cohort studies) and basic research

Externí odkaz: https://doaj.org/article/08e1aaeebb284c27b6038c936fe9774e

Decline in forced vital capacity in subjects with systemic sclerosis-associated interstitial lung disease in the SENSCIS trial compared with healthy reference subjects

Autor: Toby M. Maher, Arnaud Bourdin, Elizabeth R. Volkmann, Serena Vettori, Jörg H. W. Distler, Margarida Alves, Christian Stock, Oliver Distler

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-9 (2022)

Abstract Background The forced vital capacity (FVC) of healthy individuals depends on their age, sex, ethnicity and height. Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is characterised by loss of FVC. We compared FVC values in t

Externí odkaz: https://doaj.org/article/3c95eea0163d441fa7e873d6fac37d1a

Effectiveness and safety of tocilizumab in patients with systemic sclerosis: a propensity score matched controlled observational study of the EUSTAR cohort

Autor: Pavel I Novikov, Thierry Martin, Eric Hachulla, Vanessa Smith, Maurizio Cutolo, Yannick Allanore, Camillo Ribi, Oliver Distler, Britta Maurer, Paolo Airo, Cosimo Bruni, Veronica Codullo, Luc Mouthon, Marie Vanthuyne, Elisabetta Zanatta, Simona Rednic, Ulf Müller-Ladner, Nemanja Damjanov, Anna-Maria Hoffmann-Vold, Michele Iudici, Suzana Jordan, Jean Sibilia, Mengtao Li, Roger Hesselstrand, Elise Siegert, László Czirják, Armando Gabrielli, Dominique Farge Bancel, Yolanda Braun-Moscovici, Nicolas Hunzelmann, Raffaele Pellerito, Jörg Henes, Bojana Stamenkovic, Carlo Francesco Selmi, Mohammed Tikly, Merete Engelhart, Valeria Riccieri, Cord Sunderkötter, Francesca Ingegnoli, Francesco Paolo Cantatore, Susanne Ullman, Maria Rosa Pozzi, Piotr Wiland, Juan Jose Alegre-Sancho, Brigitte Krummel-Lorenz, Ellen De Langhe, Branimir Anic, Carolina de Souza Müller, Simon Stebbings, Alessandra Vacca, Lisa Stamp, Kamal Solanki, Douglas Veale, Esthela Loyo, Edoardo Rosato, Cristina-Mihaela Tanaseanu, Rosario Foti, Codrina Ancuta, Ira Litinsky, Lesley Ann Saketkoo, Eduardo Kerzberg, Tim Schmeiser, Piercarlo Sarzi Puttini, Fabio Cacciapaglia, Marie-Elise Truchetet, Muriel Elhai, Juan José Alegre Sancho, Ivan Castellví, Serena Vettori, Vivien M Hsu, Masataka Kuwana, Sule Yavuz, Radim Becvar, Patricia E Carreira, Eugene J Kucharz, Bernard Coleiro, Paul Hasler, Carlos de la Puente, Svetlana Agachi, Thierry Zenone, Francesco Del Galdo, Doron Rimar, Alessandro Giollo, Lidia P Ananieva, Ina Kötter, Mislav Radic, Dominik Majewski, Kristine Herrmann, Goda Seskute, Lorinda S Chung, Laura Belloli, Ulrike Held, FJ López-Longo, Joerg H W Distler, Maria João Salvador, Simon Kuster, Klaus Steigmiller, Ana-Maria Gheorghiu, Katarzyna Romanowska-Prochnicka, Yuichiro Shirai, Chris Denton, Ruxandra M Ionescu, Stefan Heitmann Vera Ortiz-Santamaria, Walid Ahmed Abdel Atty Mohamed, Paloma Garcíadela Peña Lefebvre, Vera Bernardino

Publikováno v: RMD Open, Vol 8, Iss 2 (2022)

Objectives Tocilizumab showed trends for improving skin fibrosis and prevented progression of lung fibrosis in systemic sclerosis (SSc) in randomised controlled clinical trials. We aimed to assess safety and effectiveness of tocilizumab in a real-lif

Externí odkaz: https://doaj.org/article/b661f25cc59f441ea391bc0cb68007ab