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Akademický článek

Praziquantel in the cerebrospinal fluid in neurocysticercosis

Autor: A. Spina-França, L. R. Machado, J. P. S. Nobrega, J. A. Livramento, H. W. Diekmann, E. Groll, G. L. de Rezende

Publikováno v: Arquivos de Neuro-Psiquiatria, Vol 43, Iss 3, Pp 243-259 (1985)

In 10 patients with neurocysticercosis (NC), an assessment was made of the praziquantel (PZQ) concentration in the cerebrospinal fluid (CSF), in non-deproteinized serum and in protein-free serum: before administration of the drug and the 1st., 7th. a

Externí odkaz: https://doaj.org/article/6c98c6c98b4243b1bed42e3b5d5bae80

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Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum

Autor: J. Fullekrug, W. Diekmann, P. Nguyen Van, Birte Sönnichsen, Gottfried Mieskes, D. G. Robinson

Publikováno v: Journal of Cell Science. 107:2705-2717

Many soluble resident proteins of the endoplasmic reticulum share a COOH-terminal Lys-Asp-Glu-Leu (KDEL) sequence. Current opinion favours a model in which these proteins can escape from the endoplasmic reticulum (ER) by bulk flow and are recognized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed76013f7370d3dc6c2d718d6bec5600
https://doi.org/10.1242/jcs.107.10.2705

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['Replacement Methods to Animal Testing' as the incentive topic of the German Ministry of Education and Research. Selected results on biological drugs]

Autor: W, Diekmann, M, Hansper

Publikováno v: ALTEX. 18(1)

Since 1980, BMBF, in co-operation with the appointed project representative BEO (Biology, Energy, Environment), supports research projects with the central goal of the reduction of animal testing. Beginning with the announcement about promoting "Proj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0aabb709a4f55105ff5c85fba83992cf
https://pubmed.ncbi.nlm.nih.gov/11248846

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Phenytoin and carbamazepine decrease oral bioavailability of praziquantel

Autor: A. G. Fernandes, R. Martins, C. M. Gracia, H. W. Diekmann, W. Jung, P. R. M. Bittencourt

Publikováno v: Neurology. 42:492-492

Antiepileptic drugs, especially carbamazepine and phenytoin, are potent liver enzyme inducers. Since praziquantel, the drug used to treat neurocysticercosis, undergoes extensive liver first-pass metabolism, we carried out a prospective study to verif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfd0c4fc272826114d8b818ea24023f
https://doi.org/10.1212/wnl.42.3.492

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The effect of phosphorus on the mechanism of intergranular stress corrosion cracking of mild steels in nitrate solutions

Autor: H. J. Grabke, W. Diekmann, H. J. Krautschick

Publikováno v: Corrosion Science. 28:251-258

The corrosion behavior of iron-phosphorus alloys with 0.003–2 wt% phosphorus has been studied in nitrate and sulfate solutions. The high P alloys can be considered as a model for grain boundaries with segregated phosphorus. Polarization tests indic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f15dfd114bc3d2a8eba08e15b34edeb8
https://doi.org/10.1016/0010-938x(88)90108-4

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The fate of praziquantel in the organism III. Metabolism in rat, beagle dog and rhesus monkey

Autor: K. U. Buhring, H. W. Diekmann

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 1:107-112

The radioactive constituents of specimens of serum, urine and faeces of wistar rats, beagle dogs and rhesus monkeys following peroral and intravenous administration of praziquantel-14C were analyzed by radio thin layer chromatographic techniques. Cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06f4b905254f1fcdab573db267ca591a
https://doi.org/10.1007/bf03189264

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The bonding state of carbon segregated to α-iron surfaces and on iron carbide surfaces studied by electron spectroscopy

Autor: W. Diekmann, G. Panzner

Publikováno v: Surface Science. 160:253-270

Segregated carbon on the Fe(100) surface has been studied by means of X-rayand ultraviolet photoelectron (XPS, UPS), Auger electron (AES) and electron energy loss spectroscopy (ELS). For comparison, the surfaces of polycrystalline graphite and of iro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a20a97f6f7a5649e29b561037b7b5d4
https://doi.org/10.1016/0039-6028(85)91040-4

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The fate of praziquantel in the organism I. Pharmacokinetics in animals

Autor: H. W. Diekmann, H. Nowak, K. Steiner, A. Garbe

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 1:85-95

The pharmacokinetics of14C-praziquantel were tested in various species. Intravenously injected praziquantel is rapidly absorbed by the tissues in all species. The sum of unchanged drug and metabolites is rapidly eliminated from the intravascular spac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d87e55313d4ce2dccb86c61e0a6f210b
https://doi.org/10.1007/bf03189262

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The bonding state of nitrogen segregated on Fe(100) and on iron nitrides Fe4N and Fe2N

Autor: W. Diekmann, G. Panzner, H. J. Grabke

Publikováno v: Surface Science. 218:507-518

X-ray and ultraviolet photoelectron (XPS, UPS) and electron excited Auger electron (AES) spectroscopic studies were performed on nitrogen segregated on Fe(100) and on iron nitride films. The iron-nitrogen bond in both cases is characterized by a sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c9f008d039fec2de50cfbfd193ec2b
https://doi.org/10.1016/0039-6028(89)90165-9

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