Zobrazeno 1 - 10
of 13
pro vyhledávání: '"W. Dean Pontius"'
Autor:
W. Dean Pontius, Ellen S. Hong, Zachary J. Faber, Jeremy Gray, Craig D. Peacock, Ian Bayles, Katreya Lovrenert, Diana H. Chin, Berkley E. Gryder, Cynthia F. Bartels, Peter C. Scacheri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most
Externí odkaz:
https://doaj.org/article/6bb55550fb1640888f084ae083dc4872
Autor:
Masahiro Hitomi, Anastasia P. Chumakova, Daniel J. Silver, Arnon M. Knudsen, W. Dean Pontius, Stephanie Murphy, Neha Anand, Bjarne W. Kristensen, Justin D. Lathia
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therap
Externí odkaz:
https://doaj.org/article/bc28c8e103ed4c54bc7d0532f52eaa48
Autor:
Devin Neu, Stevephen Hung, Cynthia F. Bartels, Zachary J. Faber, Katreya Lovrenert, W. Dean Pontius, Laura Morgan, Maharshi Chakraborty, Will Liao, Diana Chin, Ellen S. Hong, Jeremy Gray, Victor Moreno, Matthew Kalady, Ulrike Peters, Berkley Gryder, Richard C. Sallari, Peter C. Scacheri
Transposable elements become increasingly active in both cancerous and aging cells, driven by loss of DNA methylation as cells divide. Here we leverage the epigenomes of colon cancers with matched adjacent tissue, in addition to non-cancerous normals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b7b28d2b35a1559efaa7c0ad5fa31b
https://doi.org/10.1101/2023.05.17.541189
https://doi.org/10.1101/2023.05.17.541189
Autor:
Stevephen Hung, Alina Saiakhova, Zachary J Faber, Cynthia F Bartels, Devin Neu, Ian Bayles, Evelyn Ojo, Ellen S Hong, W Dean Pontius, Andrew R Morton, Ruifu Liu, Matthew F Kalady, David N Wald, Sanford Markowitz, Peter C Scacheri
Publikováno v:
eLife, Vol 8 (2019)
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to
Externí odkaz:
https://doaj.org/article/a8619f27054e40b480d81c4ee548d4dd
Autor:
W. Dean Pontius, Ellen S. Hong, Zachary J. Faber, Jeremy Gray, Craig Peacock, Ian Bayles, Katreya Lovrenert, Cynthia F. Bartels, Peter C. Scacheri
The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most omics stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15805f7a5613fcc61481252ddf21eb20
https://doi.org/10.1101/2022.11.15.516627
https://doi.org/10.1101/2022.11.15.516627
Autor:
Ellen S. Hong, W Dean Pontius, Yuriy Fedorov, Cynthia F. Bartels, Peter C. Scacheri, Jaret M. Karnuta, Jim Lu, Małgorzata Krajewska, Brian P. Rubin, James J. Morrow, Ian Bayles, Rani E. George, Alina Saiakhova, Drew J. Adams, Zachary J Faber
Publikováno v:
Journal of Clinical Investigation. 129:4377-4392
Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a system that enabled preclinical screening of compounds against metastatic OS cells in the contex
Autor:
Neha Anand, Stephanie Murphy, W. Dean Pontius, Masahiro Hitomi, Arnon Møldrup Knudsen, Anastasia Chumakova, Daniel J. Silver, Bjarne Winther Kristensen, Justin D. Lathia
Publikováno v:
Hitomi, M, Chumakova, A P, Silver, D J, Knudsen, A M, Pontius, W D, Murphy, S, Anand, N, Kristensen, B W & Lathia, J D 2021, ' Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells ', JCI Insight, vol. 6, no. 3, e130510 . https://doi.org/10.1172/jci.insight.130510
JCI Insight, Vol 6, Iss 3 (2021)
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI Insight
Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006523047aa37c170de03b53cb99eb64
https://findresearcher.sdu.dk:8443/ws/files/180138940/130510.2_20210125131614_covered_e0fd13ba177f913fd3156f593ead4cfd.pdf
https://findresearcher.sdu.dk:8443/ws/files/180138940/130510.2_20210125131614_covered_e0fd13ba177f913fd3156f593ead4cfd.pdf
Publikováno v:
Brain Tumors ISBN: 9781071608555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a548731df55bec1538f16928d3053653
https://doi.org/10.1007/978-1-0716-0856-2_7
https://doi.org/10.1007/978-1-0716-0856-2_7
Autor:
Daniel J. Silver, Arnon M. Knudsen, W. Dean Pontius, Masahiro Hitomi, Stephanie Murphy, Anastasia Chumakova, Justin D. Lathia, Neha Anand, Bjarne Winther Kristensen
Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6a9055e302e11eab22510101c9288e
https://doi.org/10.1101/569962
https://doi.org/10.1101/569962
Autor:
Alina Saiakhova, Ellen S. Hong, Matthew F. Kalady, Andrew R. Morton, W Dean Pontius, Zachary J Faber, Stevephen Hung, Cynthia F. Bartels, Ian Bayles, Evelyn Ojo, Peter C. Scacheri, Sanford D. Markowitz, David N. Wald, Ruifu Liu, Devin Neu
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to