Zobrazeno 1 - 10
of 145
pro vyhledávání: '"W. David Merryman"'
Autor:
Nilay Taneja, Matthew R. Bersi, Sophie M. Baillargeon, Aidan M. Fenix, James A. Cooper, Ryoma Ohi, Vivian Gama, W. David Merryman, Dylan T. Burnette
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: The mechanical properties of the actin cortex regulate shape changes during cell division, cell migration, and tissue morphogenesis. We show that modulation of myosin II (MII) filament composition allows tuning of surface tension at the cort
Externí odkaz:
https://doaj.org/article/a5824dde8be34812af865737953eca03
Autor:
Mark Vander Roest, Christopher Krapp, Joanne L. Thorvaldsen, Marisa S. Bartolomei, W. David Merryman
Publikováno v:
Physiological Reports, Vol 7, Iss 19, Pp n/a-n/a (2019)
Abstract Epigenetic dysregulation of long noncoding RNA H19 was recently found to be associated with calcific aortic valve disease (CAVD) in humans by repressing NOTCH1 transcription. This finding offers a possible epigenetic explanation for the abun
Externí odkaz:
https://doaj.org/article/bb3ffdafb7cc4086883fc9a0c886ea07
Autor:
Aaron M. Bender, Michael S. Valentine, Joshua A. Bauer, Emily Days, Craig W. Lindsley, W. David Merryman
Publikováno v:
ASSAY and Drug Development Technologies. 21:89-96
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1037-H1047
We have found that genetic ablation of the Sost gene (protein: sclerostin) prevents aortic valve stenosis in aged, Western diet mice. This is a new role for sclerostin in the cardiovascular system. To the knowledge of the authors, this is one of the
Autor:
J Ethan Joll, Cynthia R Clark, Christine S Peters, Michael A Raddatz, Matthew R Bersi, W David Merryman
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0238407 (2020)
Calcific aortic valve disease (CAVD) is a deadly disease that is rising in prevalence due to population aging. While the disease is complex and poorly understood, one well-documented driver of valvulopathy is serotonin agonism. Both serotonin overexp
Externí odkaz:
https://doaj.org/article/c52a61d3d77848bf9fe6feea4c0dc816
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H1080-H1085
This article uses in vivo and ex vivo analysis to track the development of osteoporosis and left heart cardiovascular disease in an aged, high-cholesterol diet, mouse ovariectomy model. Mice develop early left ventricle hypertrophy without concurrent
Autor:
Martin B. Leon, David E. Newby, Brian R. Lindman, Michael J. Mack, Devraj Sukul, Benoit J. Arsenault, John Lewis, Catherine M Otto, Mahesh V. Madhavan, Marc R. Dweck, Megan Coylewright, Philippe Pibarot, W. David Merryman, Frank E. Harrell
Publikováno v:
Journal of the American College of Cardiology. 78:2354-2376
Despite numerous promising therapeutic targets, there are no proven medical treatments for calcific aortic stenosis (AS). Multiple stakeholders need to come together and several scientific, operational, and trial design challenges must be addressed t
Publikováno v:
JACC: Basic to Translational Science
Publikováno v:
Am J Physiol Heart Circ Physiol
Inflammation caused by infiltrating macrophages and T cells promotes plaque growth in atherosclerosis. Cadherin-11 (CDH11) is a cell-cell adhesion protein implicated in several fibrotic and inflammatory diseases. Much of the research on CDH11 concern
Publikováno v:
JACC. Basic to translational science. 7(4)