Zobrazeno 1 - 5
of 5
pro vyhledávání: '"W. David Church"'
Autor:
W. David Church, Dennis Wegener, Tim J. Wigle, Arne Brendes, Kevin Wayne Kuntz, Demet Aybar, Paul Chang, Melissa Vasbinder, Claudia Beck, Martin Prahm, Kerren Kalai Swinger, Laurie B. Schenkel, Christina R. Majer
Publikováno v:
Slas Discovery
Mono(ADP-ribosylation) (MARylation) and poly(ADP-ribosylation) (PARylation) are posttranslational modifications found on multiple amino acids. There are 12 enzymatically active mono(ADP-ribose) polymerase (monoPARP) enzymes and 4 enzymatically active
Autor:
Tim J. Wigle, Luke Utley, Kevin Wayne Kuntz, Jeff Song, Jan-Rung Mo, W. David Church, Sunaina P. Nayak, Heike Keilhack, Yue Ren, Alvin Lu, Danielle J. Blackwell, Ryan Abo, Kaiko Kunii, Christina R. Majer, Ahmed S.A. Mady, Melissa M. Vasbinder, Ellen Bamberg, Kerren Kalai Swinger, Bin Gui, Victoria M. Richon, Mario Niepel, Patricia E. Rao, Kristy Kuplast-Barr, Jennifer R. Molina, Timothy J. Mitchison, Joseph M. Gozgit, Elena Minissale, Zacharenia A. Varsamis
Publikováno v:
Cancer cell. 39(9)
PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition of PARP7 restores type I interf
Autor:
Tim J. Wigle, Elena Minissale, Alvin Lu, Kristy Kuplast-Barr, W. David Church, Jennifer R. Molina, Heike Keilhack, Kaiko Kunii, Anne Cheung, Yue Ren, Christina R. Majer, Christopher Reik, Kevin Wayne Kuntz, Mario Niepel, Victoria M. Richon, Laurie B. Schenkel, Kerren Kalai Swinger, Jan-Rung Mo, Danielle J. Blackwell, Ryan Abo, Melissa M. Vasbinder
Publikováno v:
Cell Chemical Biology. 28:1158-1168.e13
Summary PARP14 has been implicated by genetic knockout studies to promote protumor macrophage polarization and suppress the antitumor inflammatory response due to its role in modulating interleukin-4 (IL-4) and interferon-γ signaling pathways. Here,
Autor:
Kaiko Kunii, W. David Church, Danielle J. Blackwell, Kevin Wayne Kuntz, Tim J. Wigle, Kristen McEachern, Heike Keilhack, Yue Ren, Laurie B. Schenkel, Ellen Bamberg, Prashant Shambharkar, Melissa Vasbinder, Kristy Kuplast-Barr, Christina R. Majer, Joseph M. Gozgit, Jenkins L. Lemera, Luke Utley, Victoria M. Richon, Mario Niepel
Publikováno v:
Cancer Research. 81:1344-1344
CD38 is an ADP-ribosyl cyclase that converts NAD+ to ADP-ribose (ADPR) or cyclic ADPR (cADPR) and nicotinamide. The enzyme can exist in either an ecto- or endo-catalytic orientation with different sub-cellular localization, and therefore can regulate
Autor:
Patricia E. Rao, Danielle J. Blackwell, Ryan Abo, Kaiko Kunii, Kristy Kuplast-Barr, W. David Church, Victoria M. Richon, Heike Keilhack, Melissa M. Vasbinder, Jan-Rung Mo, Luke Utley, Ellen Bamberg, Mario Niepel, Zacharenia A. Varsamis, Yue Ren, Alvin Lu, Timothy J. Mitchison, Tim J. Wigle, Christina R. Majer, Kevin Wayne Kuntz, Jeff Song, Kerren Kalai Swinger, Joseph M. Gozgit, Bin Gui, Sunaina P. Nayak
Publikováno v:
Cancer Research. 80:DDT02-01
RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function (MARylati