Zobrazeno 1 - 10
of 12
pro vyhledávání: '"W. D. Shingleton"'
Autor:
Constance E. Brinckerhoff, B. A. Degnan, P. J. T. Koshy, W. D. Shingleton, Andrew D. Rowan, Joni L. Rutter, Jon B. Catterall, Tim E. Cawston, S. Carrère
Publikováno v:
Arthritis & Rheumatism. 44:2296-2310
Objective To investigate the mechanism of interleukin-1α (IL-1α) and oncostatin M (OSM) synergistic regulation of matrix metalloproteinase 1 (MMP-1) in human chondrocytes. Methods Using an immortalized human chondrocyte cell line (T/C28a4), we inve
Autor:
P. J. T. Koshy, K. Hudson, Andrew D. Rowan, W. D. Shingleton, B. A. Degnan, P. F. Life, A. B. Vernallis, J. R. Spaull, Tim E. Cawston, John K. Heath
Publikováno v:
Arthritis & Rheumatism. 44:1620-1632
Objective To determine whether other glycoprotein 130 (gp130) binding cytokines can mimic the effects of oncostatin M (OSM) in acting synergistically with interleukin-1α (IL-1α) to induce cartilage collagen breakdown and collagenase expression, and
Publikováno v:
Journal of Cellular Biochemistry. 79:519-531
Retinoic acid (RetA) and interleukin-1alpha (IL-1) together can induce a reproducible release of proteoglycan fragments from bovine nasal cartilage in culture. However, release of collagen fragments with either agent alone is often variable. In this
Autor:
P. J. T. Koshy, Graham P. Riley, J. R. Spaull, P. F. Life, C. A. Summers, V. A. Curry, Tim E. Cawston, Andrew D. Rowan, Ian M. Clark, Mary B. Goldring, W. D. Shingleton
Publikováno v:
Arthritis & Rheumatism. 41:1760-1771
Objective. To study the interaction of interleukin-la (IL-la) and oncostatin M (OSM) in promoting cartilage collagen destruction. Methods. Bovine, porcine, and human cartilage and human chondrocytes were studied in culture. The levels of collagenase
Publikováno v:
Equine Veterinary Journal. 29:360-364
Cartilage canals have been described in most mammals and contain the vascular elements necessary for the maintenance of epiphyseal growth cartilage. The presence and longevity of cartilage canals in developing articular/epiphyseal cartilage of horses
Publikováno v:
Rheumatology (Oxford, England). 45(8)
Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integrity. This study assesses the effects of a RetA þ OSM combination on cartilage catabolism. Methods. Anim
Autor:
J B, Catterall, S, Carrère, P J, Koshy, B A, Degnan, W D, Shingleton, C E, Brinckerhoff, J, Rutter, T E, Cawston, A D, Rowan
Publikováno v:
Arthritis and rheumatism. 44(10)
To investigate the mechanism of interleukin-1alpha (IL-1alpha) and oncostatin M (OSM) synergistic regulation of matrix metalloproteinase 1 (MMP-1) in human chondrocytes.Using an immortalized human chondrocyte cell line (T/C28a4), we investigated regu
Autor:
A D, Rowan, P J, Koshy, W D, Shingleton, B A, Degnan, J K, Heath, A B, Vernallis, J R, Spaull, P F, Life, K, Hudson, T E, Cawston
Publikováno v:
Arthritis and rheumatism. 44(7)
To determine whether other glycoprotein 130 (gp130) binding cytokines can mimic the effects of oncostatin M (OSM) in acting synergistically with interleukin-1alpha (IL-1alpha) to induce cartilage collagen breakdown and collagenase expression, and to
Publikováno v:
Journal of cellular biochemistry. 79(4)
Retinoic acid (RetA) and interleukin-1alpha (IL-1) together can induce a reproducible release of proteoglycan fragments from bovine nasal cartilage in culture. However, release of collagen fragments with either agent alone is often variable. In this
Autor:
T E, Cawston, V A, Curry, C A, Summers, I M, Clark, G P, Riley, P F, Life, J R, Spaull, M B, Goldring, P J, Koshy, A D, Rowan, W D, Shingleton
Publikováno v:
Arthritis and rheumatism. 41(10)
To study the interaction of interleukin-1alpha (IL-1alpha) and oncostatin M (OSM) in promoting cartilage collagen destruction.Bovine, porcine, and human cartilage and human chondrocytes were studied in culture. The levels of collagenase (matrix metal