Výsledky vyhledávání - "W. D. Mcfadyen"

The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells

Autor: J, Whittaker, W D, McFadyen, B C, Baguley, V, Murray

Publikováno v: Anti-cancer drug design. 16(2-3)

DNA-targeted platinum phenanthridinium complexes were investigated in intact human cells and in tumour-bearing mice. The DNA sequence specificity of platinum phenanthridinium complexes was examined in intact human cells using a Taq DNA polymerase sto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfd51785d0a7007708f9548e9eb041c2
https://pubmed.ncbi.nlm.nih.gov/11962516

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Electrospray ionization tandem mass spectrometric studies of competitive pyridine loss from platinum(II) ethylenediamine complexes by the kinetic method

Autor: R J, Holmes, R A, O'Hair, W D, McFadyen

Publikováno v: Rapid communications in mass spectrometry : RCM. 14(24)

The competition between pyridine ligand loss in square planar Pt(II) complexes has been examined using the doubly and singly charged ions of complexes consisting of platinum(ethylenediamine) coordinated to two different substituted pyridines. Collisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16c6eb0b57627dc7f03d7d937d46f6f4
https://pubmed.ncbi.nlm.nih.gov/11114055

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The design of cobalt(III) complexes of phenazine-1-carboxamides as prointercalators and potential hypoxia-selective cytotoxins

Autor: L C, Perrin, W R, Wilson, W A, Denny, W D, McFadyen

Publikováno v: Anti-cancer drug design. 14(3)

A series of cobalt (III) complexes, [Co(Racac)2(L)]+, have been prepared as potential hypoxia-selective prointercalator forms of the ligands L, where L is the cytotoxic DNA mono-intercalating ligands N-[2-[(aminoethyl)amino]ethyl]-phenazine-1-carboxa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90c14f1803589ec5698e0659fd13a699
https://pubmed.ncbi.nlm.nih.gov/10500498

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Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)diamines

Autor: B D, Palmer, G, Wickham, D J, Craik, W D, McFadyen, L P, Wakelin, B C, Baguley, W A, Denny

Publikováno v: Anti-cancer drug design. 7(5)

A series of dimers of the monofunctional platinum species [Pt(dien)Cl]+, linked by a variety of flexible (polymethylene) and more rigid chains, was prepared and evaluated for DNA interactions and cytotoxic activity. The polymethylene-linked dimers we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f501493e7bf9a1e17b65d601e2a60c1a
https://pubmed.ncbi.nlm.nih.gov/1388630

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The use of Taq DNA polymerase to determine the sequence specificity of DNA damage caused by cis-diamminedichloroplatinum(II), acridine-tethered platinum(II) diammine complexes or two analogues

Autor: V, Murray, H, Motyka, P R, England, G, Wickham, H H, Lee, W A, Denny, W D, McFadyen

Publikováno v: The Journal of biological chemistry. 267(26)

cis-Diamminedichloroplatinum(II) (cisplatin) forms adducts with DNA. The sequence specificity of formation of cisplatin adducts with plasmid DNA was investigated using Taq DNA polymerase. This procedure involved the extension of an oligonucleotide pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9fa771022dba669490e70182b335fd99
https://pubmed.ncbi.nlm.nih.gov/1527009

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DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine

Autor: Geoffrey Wickham, Laurence P. G. Wakelin, William A. Denny, P. Johnson, W. D. Mcfadyen, Brian D. Palmer, Ho Huat Lee, Bruce C. Baguley

Publikováno v: Journal of medicinal chemistry. 33(11)

Two different classes of cis-diaminedichloroplatinum(II) complexes linked to the DNA-intercalating chromophore 9-anilinoacridine have been synthesized and evaluated as DNA-targeted antitumor agents. Two different Pt chelating ligands were investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a388308e9d21a1a4d84b802553c5ae1c
https://pubmed.ncbi.nlm.nih.gov/2231598

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Activity of platinum(II) intercalating agents against murine leukemia L1210

Autor: Ian A. G. Roos, V. A. Leopold, Laurence P. G. Wakelin, W. D. Mcfadyen

Publikováno v: Journal of Medicinal Chemistry. 28:1113-1116

Four series of intercalating, square-planar Pt(II) complexes derived from the ligands 2,2'-bipyridine, 2,2':6',2"-terpyridine, 1,10-phenanthroline, and 3,4,7,8-tetramethyl-1,10-phenanthroline were synthesized and aspects of their activity against mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c29ff36015571859997f18fd8305bf
https://doi.org/10.1021/jm00146a026

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Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent

Autor: Laurence P. G. Wakelin, Brian L. Hillcoat, W. D. Mcfadyen, Ian A. G. Roos

Publikováno v: Biochemical Journal. 238:757-763

A series of binuclear DNA-binding ligands was prepared by linking two (2,2′:6′,2″-terpyridine)platinum(II) moieties via alpha omega-dithiols of the type HS-[CH2]n-SH where n = 4-10. A monomeric analogue was also synthesized. Compounds were char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39317901504eba59984e626792fc2231
https://doi.org/10.1042/bj2380757

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