Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

Autor: G, Davies, R E, Marioni, D C, Liewald, W D, Hill, S P, Hagenaars, S E, Harris, S J, Ritchie, M, Luciano, C, Fawns-Ritchie, D, Lyall, B, Cullen, S R, Cox, C, Hayward, D J, Porteous, J, Evans, A M, McIntosh, J, Gallacher, N, Craddock, J P, Pell, D J, Smith, C R, Gale, I J, Deary

Publikováno v: Davies, G, Marioni, R E, Liewald, D C, Hill, W D, Hagenaars, S P, Harris, S E, Ritchie, S J, Luciano, M, Fawns-Ritchie, C, Lyall, D, Cullen, B, Cox, S R, Hayward, C, Porteous, D J, Evans, J, Mcintosh, A M, Gallacher, J, Craddock, N, Pell, J P, Smith, D J, Gale, C R & Deary, I J 2016, ' Genome-wide association study of cognitive functions and educational attainment in UK Biobank ( N =112 151) ', Molecular Psychiatry, vol. 21, no. 6, pp. 758-767 . https://doi.org/10.1038/mp.2016.45
Molecular Psychiatry

People’s differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c9140328e2face379956997bb121d81f
https://ora.ox.ac.uk/objects/uuid:5723f54c-bcaf-423c-b5e0-df6adc911665

Genetic contributions to Trail Making Test performance in UK Biobank

Autor: S P, Hagenaars, S R, Cox, W D, Hill, G, Davies, D C M, Liewald, S E, Harris, A M, McIntosh, C R, Gale, I J, Deary

Publikováno v: Molecular psychiatry. 23(7)

The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1160d19bb5065e78826294dc279a2551
https://pubmed.ncbi.nlm.nih.gov/28924184

Hypertonic Mannitol Loading of NF-κB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks Upregulation of ICAM-1

Autor: D C, Hess, E, Howard, C, Cheng, J, Carroll, W D, Hill, C Y, Hsu

Publikováno v: Stroke. 31:1179-1186

Background and Purpose —An acute inflammatory response exacerbates tissue injury during acute ischemic stroke. The transcription factor nuclear factor (NF)-κB plays a key role in endothelial cell activation and the inflammatory response. Targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905c4a297a66976988982707ca873224
https://doi.org/10.1161/01.str.31.5.1179

Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons

Autor: M M, Tompkins, E J, Basgall, E, Zamrini, W D, Hill

Publikováno v: The American journal of pathology. 150(1)

In Parkinson's disease and other Lewy-body-associated disorders, the substantia nigra pars compacta undergoes degeneration, but the mechanism of cell death has not been previously described. The substantia nigra of normal and Alzheimer's disease case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dba58d5a5f3ec3adaba963adaa6f5049
https://pubmed.ncbi.nlm.nih.gov/9006329

Characterization of the distinctive neurofilament subunits of the soma and axon initial segments in the squid stellate ganglion

Autor: Harold Gainer, W. D. Hill, Michael Tytell, Harish C. Pant

Publikováno v: Journal of neuroscience research. 25(2)

The stellate ganglion, which gives rise to the giant axons of the squid, was dissected into two parts, one containing primarily cell bodies and the other axon initial segments. A neurofilament protein-enriched extract of each was prepared and compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d0a701011ff437f12314ad8e6f262c
https://pubmed.ncbi.nlm.nih.gov/2108256