Zobrazeno 1 - 6
of 6
pro vyhledávání: '"W. D. Byrom"'
Publikováno v:
European Journal of Clinical Pharmacology. 55:827-836
Design: A randomised, double-blind, prospective, placebo-controlled four-way study of the pharmacokinetics of single oral doses of flosequinan. We do not report the placebo data in this paper. Flosequinan was given at doses of 50, 100 and 150 mg, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebacf3b1405ca9ef073df0a0cb20ee99
https://doi.org/10.1007/s002280050704
https://doi.org/10.1007/s002280050704
Publikováno v:
Journal of Biopharmaceutical Statistics. 9:439-450
Pharmacokinetic studies of drug and metabolite concentrations in the blood are usually conducted as crossover trials, especially in phases I and II. A longitudinal series of measurements is collected on each subject within each period. However, much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfa29bd21ff3ad9dadd327309b1d7be
https://doi.org/10.1081/bip-100101186
https://doi.org/10.1081/bip-100101186
Publikováno v:
Journal of Statistical Planning and Inference. 78:307-316
We describe a method for constructing D-optimal designs for nonlinear mixed effect models in cross-over pharmacokinetic studies. The method is based on fitting an approximate model using generalised least squares. The design construction is illustrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e37569235671f2f51b191f2bdda23e0c
https://doi.org/10.1016/s0378-3758(98)00221-3
https://doi.org/10.1016/s0378-3758(98)00221-3
Publikováno v:
European Journal of Anaesthesiology. 15:433-445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab823e8498b97ff42be7f9ac6067c727
https://doi.org/10.1097/00003643-199807000-00009
https://doi.org/10.1097/00003643-199807000-00009
Publikováno v:
Biometrics. 56(1)
SUMMARY. Phase I trials to study the pharmacokinetic properties of a new drug generally involve a restricted number of healthy volunteers. Because of the nature of the group involved in such studies, the appropriate distributional assumptions are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e90af395c4108e55b9efb2576bdfb6
https://pubmed.ncbi.nlm.nih.gov/10783780
https://pubmed.ncbi.nlm.nih.gov/10783780
Publikováno v:
European journal of anaesthesiology. 15(4)
A number of prospective randomized comparator studies have suggested that there is a reduction in post-operative nausea and vomiting following maintenance of anaesthesia with propofol compared with inhalational agents. We analysed these studies in mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db5e71a50c3f0fd6838cbf1d84747715
https://pubmed.ncbi.nlm.nih.gov/9699101
https://pubmed.ncbi.nlm.nih.gov/9699101