Výsledky vyhledávání - "W. Coussement"

Three-dimensional Sequential Study of the Intestinal Surface in Experimental Porcine CV 777 Coronavirus Enteritis

Autor: P. Debouck, J. Hoorens, G. Charlier, R. Ducatelle, W. Coussement

Publikováno v: Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health

Summary The intestinal surface of piglets, experimentally infected with the CV777 coronavirus, was studied at different time intervals using stereo‐microscopy, histology and scanning electron microscopy. Desquamation of epithelial cells was most se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877fa7aa559d93cfddf76ff9b794fb78
https://doi.org/10.1111/j.1439-0450.1981.tb01765.x

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Spontaneous and experimental myofibrillar hypoplasia and its relation to splayleg in newborn pigs

Autor: J. Hoorens, Richard Ducatelle, D. Maenhout, W. Coussement

Publikováno v: Journal of Comparative Pathology

The relation of myofibrillar hypoplasia to clinical splayleg was studied. A strain of Belgian Landrace sows was selected for this study because they produced pigs which had no myofibrillar hypoplasia. Myofibrillar hypoplasia could nevertheless by ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be3c304916f613ec92ea8f1f6208a9c
http://europepmc.org/articles/PMC7130433

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Evaluation of the bovine corneal opacity-permeability assay as an in vitro alternative to the Draize eye irritation test

Autor: M. Sysmans, H. Van Cauteren, Gh. Deknudt, Ph. Vanparys, G. Teuns, W. Coussement

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 7(4)

The bovine corneal opacity-permeability assay (BCO-P) was evaluated as an in vitro alternative test model for the Draize eye irritancy test. Fifty pharmaceutical and commercially available compounds were tested in the BCO-P assay. The compounds were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da328e3334c16ea22de49dbb99a3638
https://pubmed.ncbi.nlm.nih.gov/20732236

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Strategies for handling unexpected endocrine findings in early safety assessment

Autor: R, De Coster, P, Vinken, W, Coussement

Publikováno v: Current opinion in drug discoverydevelopment. 3(1)

Early assessment of the endocrine toxicity of pharmaceuticals has received increasing scientific attention due to the important issue of endocrine disrupters, and the need to evaluate mechanisms and relevance to humans of early toxicity findings in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58e7c58df35dad9ddd0a6a3a8c826672
https://pubmed.ncbi.nlm.nih.gov/19649844

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The industry view on long-term toxicology testing in drug development of human pharmaceuticals

Autor: Herman Van Cauteren, W. Coussement, Philip Bentley, Jenny Sims, Gerd Bode, André Cordier, Peter Heining

Publikováno v: Pharmacologytoxicology. 86

The approach to chronic toxicity testing over the past decade is reviewed and assessed in the light of developing ICH guidelines. The 1990's have seen a general acceptance that studies with a maximal duration of 6 months in rodents are all that is re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e0795d4ef71d26d13c9450b2619fce
https://pubmed.ncbi.nlm.nih.gov/10905744

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Review of alternative methods of carcinogenicity testing and evaluation of human pharmaceuticals

Autor: K, Van Deun, H, Van Cauteren, J, Vandenberghe, M, Canning, P, Vanparys, W, Coussement

Publikováno v: Adverse drug reactions and toxicological reviews. 16(4)

Hundreds of pharmaceuticals have been reported to give a positive result in the standard "Chronic Bioassay", which consists of an 18 to 24 month daily administration of the test compound in mice and rats. This is in contrast with 20 pharmaceuticals,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df6ef732bc4b924915fcdf9c95404268
https://pubmed.ncbi.nlm.nih.gov/9608857

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