Výsledky vyhledávání - "W. Cockerill"

Investigating the Effect of a Single Infusion of Reconstituted High-Density Lipoprotein in Patients with Symptomatic Carotid Plaques

Autor: Lawrence Hayes, Robin N. Poston, Hosaam Nasr, Gillian W. Cockerill, David Gaze, Evelyn Torsney, Russell Basser, Matthew M Thompson, Ian M. Loftus

Publikováno v: Annals of Vascular Surgery

Background Elevation of plasma high-density lipoprotein (HDL) cholesterol concentration reduces cardiovascular mortality and morbidity. HDLs have been shown to possess acute anti-inflammatory, antioxidant, and antithrombotic properties. We hypothesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07225ab64ac7471dce2bf98b186ae8c9
https://doi.org/10.1016/j.avsg.2015.04.084

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Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm

Autor: Nicoletta Charolidi, Gillian W. Cockerill, Evelyn Torsney, Grisha Pirianov, Axel Nohturfft, Stuart Pearce, Ken Laing

Publikováno v: Journal of Vascular Research. 52:81-93

Peroxisome proliferator-activated receptor γ agonists have been shown to inhibit angiotensin II (AngII)-induced experimental abdominal aortic aneurysms. Macrophage infiltration to the vascular wall is an early event in this pathology, and therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2622663067d03a9ff8501a9db3bffae5
https://doi.org/10.1159/000430986

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XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation

Autor: Zhixin Jiang, Daniel Martin, Benyu Ma, Ye-Guang Chen, Zhongyi Zhang, Ting Chen, Saydul Alam, Eirini Karamariti, Andriani Margariti, Anna Zampetaki, Lingfang Zeng, Yanhua Hu, Gillian W. Cockerill, Gema Vizcay-Barrena, Wen Wang, Qingbo Xu, Chan Gao, Hongling Li, Qingzhong Xiao

Publikováno v: Journal of Biological Chemistry. 288:859-872

Sustained activation of X-box-binding protein 1 (XBP1) results in endothelial cell (EC) apoptosis and atherosclerosis development. The present study provides evidence that XBP1 mRNA splicing triggered an autophagic response in ECs by inducing autopha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813c10014fb552a0a0b3c4a5845e6792
https://doi.org/10.1074/jbc.m112.412783

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Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of β-Catenin

Autor: Eirini Karamariti, Hongling Li, Yanhua Hu, Anna Zampetaki, Lingfang Zeng, Qingbo Xu, Gillian W. Cockerill, Xiaoke Yin, Manuel Mayr, Elena De Falco, Zhongyi Zhang, Qingzhong Xiao, Daniel Martin, Andriana Margariti, Boda Zhou

Publikováno v: Circulation Research. 106:1202-1211

Rationale : Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. Objective : This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7ac613d842139f45637813e1109d0e
https://doi.org/10.1161/circresaha.109.213165

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Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow

Autor: Gang Wang, Yanhua Hu, Justin C. Mason, Gillian W. Cockerill, Qingzhong Xiao, Qingbo Xu, Elena deFalco, Anna Elena Pepe, Zhongyi Zhang, Andriana Margariti, Ouassila Habi, Lingfang Zeng, Anna Zampetaki, Hongling Li

Publikováno v: Circulation. 121:132-142

Background— Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834444f4981ed3b16b41e5a906daa423
https://doi.org/10.1161/circulationaha.109.890491

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Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms

Autor: Franklyn A. Howe, Rajdeep Deb, David Gaze, Evelyn Torsney, Mathew M. Thompson, Yanosha Gnaneswaran, Gillian W. Cockerill, Mathew Dunkley, Hosaam Nasr, Alun Jones, Ian M. Loftus

Publikováno v: Circulation. 119:3125-3132

Background— Development and rupture of aortic aneurysms involve a combination of complex biological processes. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, has been shown to have a broad spectrum of effects in vivo. The h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29673a368253f9b5ed930da2b9d0a7c2
https://doi.org/10.1161/circulationaha.109.852467

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Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

Autor: Lingfang Zeng, Shu Chien, Anna Zampetaki, Saydul Alam, Qingbo Xu, Zheng-Gen Jin, Andriana Margariti, Anna Elena Pepe, Wen Wang, Yi-shuan Julie Li, Gillian W. Cockerill, Yanhua Hu, Qingzhong Xiao, Daniel Martin, Kazutoshi Mori

Publikováno v: Proceedings of the National Academy of Sciences; Vol 106

X-box binding protein 1 (XBP1) is a key signal transducer in endoplasmic reticulum stress response, and its potential role in the atherosclerosis development is unknown. This study aims to explore the impact of XBP1 on maintaining endothelial integri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eb7ef12787e6e857f6e89052d818bb

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Increased expression of Lamin A/C correlates with regions of high wall-stress in abdominal aortic aneurysms

Autor: Amir Malkawi, Grisha Pirianov, Evelyn Torsney, Ian Chetter, Natzi Sakalihasan, Ian Loftus, Ian Norden, Christopher Huggins, Nicoletta Charolidi, Matt Thompson, Xie Yun Xu, Gillian W. Cockerill

Background: Since aortic diameter is the most significant risk factor for rupture, we sought to identify stress-dependent changes in gene expression to illuminate novel molecular processes in aneurysm rupture. \ud Materials and Methods: We constructe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8763fa1341cab9171abaadc7f14aa6
https://arro.anglia.ac.uk/id/eprint/700715/7/Malkawi_2016.pdf

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A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development

Autor: Gillian W. Cockerill, Frank Neumann, Stuart Pearce, Francesco Peri, Christopher L. Huggins, Grisha Pirianov

Publikováno v: Atherosclerosis. 242(2)

Objectives:\ud The toll-like receptors (TLRs), including TLR4, have been shown to play a crucial role in vascular inflammatory diseases, such as atherosclerosis and aneurysm. The main goal of this study was to determine the potential of IAXO-102 (Inn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9472c5d7712e68e5bb371bdef40946
https://pubmed.ncbi.nlm.nih.gov/26318106

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