Zobrazeno 1 - 10
of 66
pro vyhledávání: '"W. Clay Smith"'
Autor:
Caryn E. Plummer, Timothy Polk, Jatin Sharma, Sanghyo Sarah Bae, Olivia Barr, Amari Jones, Holly Kitchen, Michelle Wilhelmy, K. Devin, W. Clay Smith, Bryan D. Kolaczkowski, Joseph Larkin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Equine recurrent uveitis (ERU) is a painful and debilitating autoimmune disease and represents the only spontaneous model of human recurrent uveitis (RU). Despite the efficacy of existing treatments, RU remains a leading cause of visual hand
Externí odkaz:
https://doaj.org/article/115c6235f83c49b2a22704b302d20713
Autor:
Gavin W. Roddy, Uttio Roy Chowdhury, Kjersten J. Anderson, Tommy A. Rinkoski, Cheryl R. Hann, Vince A. Chiodo, W. Clay Smith, Michael P. Fautsch
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Glaucoma is the leading cause of irreversible blindness worldwide. Therapies for glaucoma are directed toward reducing intraocular pressure (IOP), the leading risk factor and only reliable therapeutic target via topical medications or with procedural
Externí odkaz:
https://doaj.org/article/de3b8256093f4bae8ab204c4ccaf5879
Autor:
Lei Lei, Radouil Tzekov, Huapeng Li, J. Hugh McDowell, Guangping Gao, W. Clay Smith, Shibo Tang, Shalesh Kaushal
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 4, p 728 (2017)
The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is dependent on the effectiveness of photoreceptor outer segment material degradation. This study explored the role of autophagy in the fate of RPE lipofuscin degradation. After s
Externí odkaz:
https://doaj.org/article/2ae2ef67eed346c38d8cc26eb04a9cfa
Publikováno v:
Human Gene Therapy. 33:695-707
Glucose metabolism in the retina is carefully orchestrated, with glucose being delivered to photoreceptors from the choroidal circulation through the retinal pigmented epithelium (RPE). In photoreceptors, glucose is processed principally by aerobic g
Autor:
Mi-Hyun Nam, Rooban B. Nahomi, Mina B. Pantcheva, Armaan Dhillon, Vince A. Chiodo, W. Clay Smith, Ram H. Nagaraj
Publikováno v:
Translational vision sciencetechnology. 11(11)
Ocular hypertension is a significant risk factor for vision loss in glaucoma caused by the death of retinal ganglion cells (RGCs). We investigated whether small heat shock proteins (sHsps) expressed in RGCs protect those cells against ocular hyperten
Autor:
Lei Xu, William N. Ruddick, Susan N. Bolch, Mikael Klingeborn, Frank M. Dyka, Manoj M. Kulkarni, Chiab P. Simpson, William A. Beltran, Catherine Bowes Rickman, W. Clay Smith, Astra Dinculescu
Publikováno v:
The American Journal of Pathology.
Autor:
Lei, Xu, William N, Ruddick, Susan N, Bolch, Mikael, Klingeborn, Frank M, Dyka, Manoj M, Kulkarni, Chiab P, Simpson, William A, Beltran, Catherine, Bowes Rickman, W Clay, Smith, Astra, Dinculescu
Publikováno v:
The American journal of pathology.
A pathologic feature of late-onset retinal degeneration caused by the S163R mutation in C1q-tumor necrosis factor-5 (C1QTNF5) is the presence of unusually thick deposits between the retinal pigmented epithelium (RPE) and the vascular choroid, conside
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148773 (2016)
PURPOSE:Bardet-Biedl syndrome is a complex ciliopathy that usually manifests with some form of retinal degeneration, amongst other ciliary-related deficiencies. One of the genetic causes of this syndrome results from a defect in Bardet-Biedl Syndrome
Externí odkaz:
https://doaj.org/article/1a739a90ec1145d5a8331fdc54dbaad3
An arrestin-1 surface opposite of its interface with photoactivated rhodopsin engages with enolase-1
Autor:
Connie Jaqueline Miranda, Susan Bolch, Nader Kamel, Jacob T. Andring, W. Clay Smith, Nicole Fernandez, Daniel Turner, Del Benzenhafer, Robert McKenna
Publikováno v:
The Journal of Biological Chemistry
Arrestin-1 is the arrestin family member responsible for inactivation of the G protein–coupled receptor rhodopsin in photoreceptors. Arrestin-1 is also well-known to interact with additional protein partners and to affect other signaling cascades b
Autor:
Lei Xu, Omar Akil, William W. Hauswirth, Seth Blackshaw, Clayton Santiago, Frank M. Dyka, John D. Ash, Susan Bolch, Kirill A. Martemyanov, James T. Handa, Astra Dinculescu, W. Clay Smith, Ekaterina S. Lobanova, Yuchen Wang
Publikováno v:
The Journal of Pathology
Usher syndrome type 3 (USH3) is an autosomal recessively inherited disorder caused by mutations in the gene clarin‐1 (CLRN1), leading to combined progressive hearing loss and retinal degeneration. The cellular distribution of CLRN1 in the retina re