Zobrazeno 1 - 9
of 9
pro vyhledávání: '"W. Casey Wilson"'
Autor:
Robyn Puro, Prabir Chakraborty, John Richards, Ronald Hiebsch, Michael Donio, W Casey Wilson, Benjamin Capoccia, Carrie Brachmann, Vicki Sung, Arun Kashyap, Daniel Pereira
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/b1c4691d570a499f94d4b96fa9ac0ba2
Autor:
John R. Richards, Daniel S. Pereira, Robyn J Puro, Arun K Kashyap, Vicki Sung, Ronald R. Hiebsch, Prabir Chakraborty, W. Casey Wilson, Michael J. Donio, Carrie Baker Brachmann, Benjamin J. Capoccia
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Overexpression of CD47 by tumor cells exploits an immune checkpoint preventing tumor recognition and destruction by innate immune cells. Binding of tumor CD47 to SIRPα on macrophages and dendritic cells triggers a ‘don’t eat me’ sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf553c0b15649e4e49fce94c84be056
https://doaj.org/article/b1c4691d570a499f94d4b96fa9ac0ba2
https://doaj.org/article/b1c4691d570a499f94d4b96fa9ac0ba2
Autor:
W. Casey Wilson, Bo Zhang, Grant A. Challen, Elizabeth L. Ostrander, Cates Mallaney, Won Kyun Koh, Ashley C. Kramer
Publikováno v:
Experimental Hematology. 57:14-20
Genome sequencing efforts have identified virtually all of the important mutations in adult myeloid malignancies. More recently, population studies have identified cancer-associated variants in the blood of otherwise healthy individuals as they age,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ccd8513ec57ec668bf1000acb3dba59
https://doi.org/10.1016/j.exphem.2017.09.004
https://doi.org/10.1016/j.exphem.2017.09.004
Autor:
Mike J Donio, Daniel S. Pereira, Robyn J Puro, Benjamin J. Capoccia, W. Casey Wilson, Isra M. Darwech, Gabriela Andrejeva, Arun K Kashyap
Publikováno v:
Blood. 136:9-10
While T cell checkpoint inhibitors are mainstays of cancer immunotherapy, therapies that direct innate immune responses against cancer are lacking. CD47, a "don't eat me" signal, is an innate immune cell checkpoint which binds SIRPα on macrophages a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55374beb68c6604ac9983abbd0087f4f
https://doi.org/10.1182/blood-2020-140528
https://doi.org/10.1182/blood-2020-140528
Autor:
Elizabeth L, Ostrander, Won Kyun, Koh, Cates, Mallaney, Ashley C, Kramer, W Casey, Wilson, Bo, Zhang, Grant A, Challen
Publikováno v:
Experimental hematology. 57
Genome sequencing efforts have identified virtually all of the important mutations in adult myeloid malignancies. More recently, population studies have identified cancer-associated variants in the blood of otherwise healthy individuals as they age,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5768f24432b72e55c56a29a9a8ea6817
https://pubmed.ncbi.nlm.nih.gov/28939416
https://pubmed.ncbi.nlm.nih.gov/28939416
Autor:
Myriam N. Bouchlaka, John O. Richards, Ben J Capoccia, W. Casey Wilson, Prabir K. Chakraborty, Michael J. Donio, Ronald R. Hiebsch, Daniel S. Pereira, Robyn J Puro, Victoria Sung
Publikováno v:
Blood. 134:1844-1844
AO-176 is a highly differentiated, humanized anti-CD47 IgG2 antibody that is unique among agents in this class of checkpoint inhibitors. AO-176 works by blocking the "don't eat me" signal, the standard mechanism of anti-CD47 antibodies, but also by d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ef5af109032e653039ca2a30b9e38a
https://doi.org/10.1182/blood-2019-126298
https://doi.org/10.1182/blood-2019-126298
Autor:
Ronald R. Hiebsch, Myriam N. Bouchlaka, Benjamin J. Capoccia, Michael J. Donio, Prabir Chakraborty, W. Casey Wilson, Robyn J. Puro, Daniel S. Pereira
Publikováno v:
Cancer Research. 79:548-548
Targeting immune checkpoints of adaptive immunity has shown great therapeutic efficacy in oncology, but in a limited fraction of patients. Innate immune cells represent the most abundant immune cell types in many solid tumors and are often linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41d9a7f2357b5040f058ada87ae7d957
https://doi.org/10.1158/1538-7445.am2019-548
https://doi.org/10.1158/1538-7445.am2019-548
Autor:
Daniel S. Pereira, Alun Carter, Benjamin J. Capoccia, Ronald R. Hiebsch, Michael J. Donio, Robert W. Carr, Robyn J Puro, Pamela T. Manning, W. Casey Wilson
Publikováno v:
Cancer Immunology Research. 7:A147-A147
Recent success in cancer immunotherapy has targeted immune checkpoints such as PD-1, PDL-1, and CTLA-4 to enhance the cytotoxic activity of the adaptive T-cell immune response. While the clinical response to these therapies has been dramatic for some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6820d8e2cc7061aff8a97356be691203
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a147
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a147
Autor:
Robyn J Puro, Prabir Chakraborty, Daniel S. Pereira, Karr Robert W, Ronald R. Hiebsch, Vicki Sung, Pamela T. Manning, Alun Carter, Ben J Capoccia, W. Casey Wilson, Michael J. Donio, Myriam N. Bouchlaka
Publikováno v:
Blood. 132:4180-4180
Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal tissues and over-expressed on several tumors. Binding of tumor CD47 to signal regulatory prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038310bbb181c9a7fcb06500b4818b1e
https://doi.org/10.1182/blood-2018-99-118456
https://doi.org/10.1182/blood-2018-99-118456