Zobrazeno 1 - 10
of 13
pro vyhledávání: '"W. C. Weinberg"'
Autor:
W C Weinberg, Robert J. McEvilly, V Vasilyev, Bogi Andersen, Mark R. Pittelkow, Michael G. Rosenfeld, Farideh Hooshmand, John R. Bermingham, S H Yuspa, O Rennekampff, J F Hansbrough
Publikováno v:
Genes & Development. 11:1873-1884
Here we report on investigation of the role of the POU domain genes Skin-1a/i (Skn-1a/i/Epoc/Oct-11) and Testes-1 (Tst-1/Oct-6/SCIP) in epidermis where proliferating basal keratinocytes withdraw from the cell cycle, migrate suprabasally, and terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498835db1f01d6870c26cb3997713600
https://doi.org/10.1101/gad.11.14.1873
https://doi.org/10.1101/gad.11.14.1873
Autor:
W C, Weinberg, E, Fernandez-Salas, D L, Morgan, A, Shalizi, E, Mirosh, E, Stanulis, C, Deng, H, Hennings, S H, Yuspa
Publikováno v:
Cancer research. 59(9)
Tumor suppression by p53 is believed to reside in its ability to regulate gene transcription, including up-regulation of p21WAF1. In p53(-/-) mice, chemical- or oncogene-induced skin tumors undergo accelerated malignant conversion. To determine the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e25e664092b292ce19c0781c881b142
https://pubmed.ncbi.nlm.nih.gov/10232585
https://pubmed.ncbi.nlm.nih.gov/10232585
Publikováno v:
Molecular carcinogenesis. 21(1)
We previously demonstrated that after transduction with the v-Ha-ras oncogene and grafting onto nude mouse hosts, primary epidermal keratinocytes with a null mutation in the p53 gene form tumors with increased growth rates and predisposition to malig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f33d953fd54541e12da5cf0d5af11e5
https://pubmed.ncbi.nlm.nih.gov/9473771
https://pubmed.ncbi.nlm.nih.gov/9473771
Publikováno v:
Cancer research. 56(16)
Alterations in expression of or responsiveness to transforming growth factor beta (TGF-beta) are frequently found in human and animal epithelial cancers and are though to be important for loss of growth control in the neoplastic cell. We show here th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35f5bdbe0a3510aff6a940701daf7967
https://pubmed.ncbi.nlm.nih.gov/8706000
https://pubmed.ncbi.nlm.nih.gov/8706000
Publikováno v:
Oncogene. 10(12)
The regulation of p53 protein synthesis and p53-mediated gene transactivation were evaluated in cultured mouse keratinocytes maintained as basal cells or induced to differentiate by Ca2+0.1 mM. p53 protein half-life, p53 protein synthesis and the lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::063124ec30597d8ec4283e19161a4e8e
https://pubmed.ncbi.nlm.nih.gov/7784075
https://pubmed.ncbi.nlm.nih.gov/7784075
Publikováno v:
Methods in enzymology. 254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc0e75d3236efe09ab87da564cef78be
https://pubmed.ncbi.nlm.nih.gov/8531694
https://pubmed.ncbi.nlm.nih.gov/8531694
Publikováno v:
Cancer research. 54(21)
Epidermal keratinocyte cultures were established from newborn mice expressing a null mutation in the p53 gene to explore the contribution of p53 to epidermal growth regulation and neoplasia. Keratinocytes were initiated by transduction with a replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::019e3d702c4c97d763c326e6f9327c86
https://pubmed.ncbi.nlm.nih.gov/7923201
https://pubmed.ncbi.nlm.nih.gov/7923201
Publikováno v:
International Journal of Cancer. 39:778-784
A number of current models of carcinogenesis postulate that rare events are critical in the formation of malignant neoplasms. The most fundamental prediction of the hypothesis that these events are rare is the clonality of neoplasms. Evidence from sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4553f684b069dee3dafb00815151fcc6
https://doi.org/10.1002/ijc.2910390621
https://doi.org/10.1002/ijc.2910390621
Autor:
Philip M. Iannaccone, W. C. Weinberg
Publikováno v:
Journal of Experimental Zoology. 243:217-223
A series of chimeric rats was used to investigate the histogenesis of the adrenal cortex. These animals were produced by amalgamating preimplantation embryos of two congenic strains which express different alloantigens of the major histocompatibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43d4de6c2870aba8b5a6afdecd818e2
https://doi.org/10.1002/jez.1402430207
https://doi.org/10.1002/jez.1402430207
Autor:
Philip M. Iannaccone, W. C. Weinberg
Publikováno v:
Journal of Cell Science. 89:423-431
The clonality of chemically induced altered hepatocellular foci was examined in rat liver. Chimeric rats composed of two histologically distinguishable cell lineages were placed on an initiation-promotion protocol for liver cancer induction. This res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4a44b5adb9b077183c399d8553134a
https://doi.org/10.1242/jcs.89.3.423
https://doi.org/10.1242/jcs.89.3.423