Zobrazeno 1 - 10
of 26
pro vyhledávání: '"W. C. O'Neill"'
Publikováno v:
American Journal of Physiology-Cell Physiology. 281:C1948-C1953
The Na-K-2Cl cotransporter NKCC1 is an important volume-regulatory transporter that is regulated by cell volume and intracellular Cl−. This regulation appears to be mediated by phosphorylation of NKCC1, although there is evidence for additional, cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759a638dbeed8f7e42ca8890d7f62bb8
https://doi.org/10.1152/ajpcell.2001.281.6.c1948
https://doi.org/10.1152/ajpcell.2001.281.6.c1948
Publikováno v:
American Journal of Physiology-Cell Physiology. 273:C316-C322
The mechanism by which cell swelling and other physical forces increase the intracellular Ca2+ concentration ([Ca2+]i) is poorly defined. In vascular endothelial cells, the increase in [Ca2+]i after hypotonic swelling was independent of external Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4141d02454779d2a2cf935bdfd224ab9
https://doi.org/10.1152/ajpcell.1997.273.1.c316
https://doi.org/10.1152/ajpcell.1997.273.1.c316
Publikováno v:
American Journal of Physiology-Cell Physiology. 272:C1968-C1979
Previously, we suggested that myosin light chain kinase (MLCK) is involved in shrinkage-induced activation of the Na+/H+ exchanger in rat astrocytes. Here we have studied the effects of hyperosmotic exposure in C6 glioma cells, a common model for ast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d8077c3dc87ddcabc337c91050d555
https://doi.org/10.1152/ajpcell.1997.272.6.c1968
https://doi.org/10.1152/ajpcell.1997.272.6.c1968
Autor:
W. C. O'Neill, P. B. Perry
Publikováno v:
American Journal of Physiology-Cell Physiology. 265:C763-C769
K efflux pathways responsible for regulatory volume decrease (RVD) were examined in bovine aortic endothelial cells. Hypotonic swelling produced a rapid and reversible threefold increase in bumetanide-insensitive 86Rb efflux. Swelling-activated 86Rb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac737fb7f086e1085150989833b1043
https://doi.org/10.1152/ajpcell.1993.265.3.c763
https://doi.org/10.1152/ajpcell.1993.265.3.c763
Autor:
W C O'Neill, Janet D. Klein
Publikováno v:
Journal of Biological Chemistry. 265:22238-22242
Simultaneous measurements of potassium influx and binding of [3H]bumetanide were performed in endothelial cells cultured from bovine aortas to determine how bradykinin regulates Na-K-2Cl cotransport. [3H]Bumetanide displayed saturable binding and was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50919663595ef29ed30cbb1a09570b01
https://doi.org/10.1016/s0021-9258(18)45695-5
https://doi.org/10.1016/s0021-9258(18)45695-5
Publikováno v:
The American journal of physiology. 277(3)
Cell shrinkage phosphorylates and activates the Na-K-2Cl cotransporter (NKCC1), indicating the presence of a volume-sensitive protein kinase. To identify this kinase, extracts of normal and shrunken aortic endothelial cells were screened for phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14231b02980f114962bbf9336ed37f17
https://pubmed.ncbi.nlm.nih.gov/10484329
https://pubmed.ncbi.nlm.nih.gov/10484329
Autor:
Janet D. Klein, W. C. O'Neill
Publikováno v:
The American journal of physiology. 269(6 Pt 1)
To identify protein kinases that are regulated by cell volume, we examined protein phosphorylation in hypertonically shrunken aortic endothelial cells. Shrinkage reversibly increased, and swelling decreased, phosphorylation of a 19-kDa cytoskeletal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16811febbab4350e2b28dd9c147c8431
https://pubmed.ncbi.nlm.nih.gov/8572182
https://pubmed.ncbi.nlm.nih.gov/8572182
Autor:
W. C. O'Neill
Publikováno v:
The American journal of physiology. 269(4 Pt 1)
The role of K+ channels and intracellular [Ca2+] in flow-induced nitric oxide (NO) production was investigated in bovine aortic endothelial cells in culture. NO release (measured as nitrite production) and K+ channel activity (measured as 86Rb+ efflu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922018e5adff2c877a0448c0dcaefa70
https://pubmed.ncbi.nlm.nih.gov/7485454
https://pubmed.ncbi.nlm.nih.gov/7485454
Publikováno v:
The American journal of physiology. 269(1 Pt 1)
Primary rat astrocytes exposed to hyperosmotic solutions undergo Na(+)-dependent amiloride-sensitive alkalinization of 0.36 U [measured with the pH-sensitive fluorescent dye 2',7'-bis(carboxyethyl)-5(6)-carboxy-fluorescein], suggesting that shrinkage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a3316d099a9bf8d2fd7e40e6a4f19a
https://pubmed.ncbi.nlm.nih.gov/7631753
https://pubmed.ncbi.nlm.nih.gov/7631753
Autor:
D. F. Steinberg, W. C. O'Neill
Publikováno v:
The American journal of physiology. 269(1 Pt 1)
To determine whether the activation of Na(+)-K(+)-2Cl- cotransport by Ca(2+)-mobilizing agonists is a direct effect of Ca2+ or is secondary to activation of Ca(2+)-dependent K+ channels [via cell shrinkage or decreased intracellular Cl- concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c06fadbb798da42fe76feff2cae10b
https://pubmed.ncbi.nlm.nih.gov/7631754
https://pubmed.ncbi.nlm.nih.gov/7631754