Zobrazeno 1 - 10 of 641 pro vyhledávání: '"W. Brehm"'
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Akademický článek
Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model
Autor: A. B. Ahrberg, C. Horstmeier, D. Berner, W. Brehm, C. Gittel, A. Hillmann, C. Josten, G. Rossi, S. Schubert, K. Winter, J. Burk
Publikováno v: BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demonstrated that MSC engr
Externí odkaz: https://doaj.org/article/c9443485a0a24858a5495dd263de8060
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2
Data reduction for serial crystallography using a robust peak finder
Autor: Anton Barty, Romain Letrun, Marco Kloos, Dominik Oberthuer, Dana Komadina, W. Brehm, Luca Gelisio, Adrian P. Mancuso, Brian Abbey, M. Galchenkova, Alireza Sadri, Henry N. Chapman, Grant Mills, Oleksandr Yefanov, Henry Kirkwood, Raphael de Wijn, Connie Darmanin, Marjan Hadian-Jazi, Mohammad Vakili
Publikováno v: Journal of applied crystallography 54(5), 1360-1378 (2021). doi:10.1107/S1600576721007317
Journal of Applied Crystallography
This article focuses on the challenges of hit finding and data reduction in serial crystallography (SX). An effective and reliable Bragg-peak-finding method, called robust peak finder (RPF), has been developed. RPF is based on the principle of robust
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85723e39acf81094e2ce380433038e99
https://doi.org/10.1107/s1600576721007317
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3
Akademický článek
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7
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
Autor: M. Schwinzer, Faisal Hammad Mekky Koua, Ashwin Chari, J. Lieske, Maria Garcia-Alai, Gleb Bourenkov, Russell J. Cox, Salah Awel, W. Ewert, Dušan Turk, Luca Gelisio, N. Werner, Hévila Brognaro, J. Pletzer-Zelgert, Juraj Knoska, Arwen R. Pearson, D. Melo, Matthias Rarey, Ilona Dunkel, Boris Krichel, Y. Gevorkov, A. Tolstikova, David von Stetten, Eike C. Schulz, Andrea Zaliani, Winfried Hinrichs, F. Trost, Helen M. Ginn, Xinyuanyuan Sun, Stephan Niebling, Holger Fleckenstein, Aleksandra Usenik, J. Wollenhaupt, Robin Schubert, Stephan Günther, Kristina Lorenzen, J. Boger, P. Reinke, Diana C. F. Monteiro, Bruno Alves Franca, Isabel Bento, Manfred S. Weiss, Ariana Peck, Dominik Oberthuer, Pedram Mehrabi, Pontus Fischer, Sebastian Günther, Jure Loboda, P. Lourdu Xavier, C. Schmidt, Christian Betzel, Huijong Han, N. Ullah, Philip Gribbon, Aida Rahmani Mashhour, Charlotte Uetrecht, Guillaume Pompidor, Christiane Ehrt, Christian G. Feiler, Saravanan Panneerselvam, Bernhard Ellinger, Christian M. Günther, Thomas J. Lane, Linlin Zhang, S. Meier, Tobias Beck, Henry N. Chapman, M. Domaracky, Sven Falke, Katarina Karničar, Markus Wolf, Cromarte Rogers, S. Saouane, Ivars Karpics, Rolf Hilgenfeld, Gisel E. Peña-Murillo, Vasundara Srinivasan, Alke Meents, Miriam Barthelmess, M. Galchenkova, B. Seychell, Beatriz Escudero-Pérez, Thomas A. White, Janine-Denise Kopicki, Joanna J. Zaitseva-Doyle, W. Brehm, M. Groessler, Brenna Norton-Baker, Frank Schlünzen, Chufeng Li, Henning Tidow, Maria Kuzikov, Andrea R. Beccari, Johanna Hakanpää, Henry Gieseler, Yaiza Fernández-García, Oleksandr Yefanov, Thomas R. Schneider, Anna Hänle, Jan Meyer, H. Andaleeb, V. Hennicke
Publikováno v: Science (New York, N.y.)
Science 372 (6542): 642-646 (2021-05-07)
Science
Science / Science now 372(6542), 642-646 (2021). doi:10.1126/science.abf7945
A large-scale screen to target SARS-CoV-2 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome is initially expressed as two large polyproteins. Its main protease, Mpro, is essential to yield functional viral proteins, making it a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7f9ac410aabd144f9e9014ed83aff5
https://resolver.caltech.edu/CaltechAUTHORS:20201113-100151878
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8
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Autor: Henry Gieseler, David von Stetten, A. Tolstikova, Luca Gelisio, Yaiza Fernández-García, Guillaume Pompidor, Saravanan Panneerselvam, Cromarte Rogers, M. Galchenkova, Juraj Knoska, B. Seychell, Gleb Bourenkov, Ariana Peck, Stephan Niebling, D. Melo, Hévila Brognaro, Russell J. Cox, Rolf Hilgenfeld, W. Brehm, J. Lieske, Matthias Rarey, Aleksandra Usenik, Tobias Beck, Oleksandr Yefanov, Henry N. Chapman, Isabel Bento, C. Schmidt, M. Groessler, Ashwin Chari, Sven Falke, Katarina Karničar, Thomas J. Lane, Beatriz Escudero-Pérez, J. Boger, Bernhard Ellinger, Christian M. Günther, Christiane Ehrt, Markus Wolf, Jure Loboda, Thomas R. Schneider, Andrea Zaliani, P. Lourdu Xavier, Eike C. Schulz, J. Wollenhaupt, Brenna Norton-Baker, Ivars Karpics, Salah Awel, Aida Rahmani Mashhour, Frank Schlünzen, Chufeng Li, Henning Tidow, Robin Schubert, Y. Gevorkov, H. Andaleeb, P. Reinke, Stephan Günther, Christian G. Feiler, Manfred S. Weiss, Jo J. Zaitsev-Doyle, N. Ullah, M. Domaracky, Pontus Fischer, Linlin Zhang, Maria Kuzikov, V. Hennicke, W. Ewert, Faisal Hammad Mekky Koua, P. Gribbon, Xinyuanyuan Sun, Dominik Oberthuer, S. Meier, J. Pletzer-Zelgert, Kristina Lorenzen, Christian Betzel, M. Schwinzer, Bruno Alves Franca, Charlotte Uetrecht, S. Saouane, Pedram Mehrabi, Helen M. Ginn, Andrea R. Beccari, Johanna Hakanpää, Diana C. F. Monteiro, Ilona Dunkel, Janine-Denise Kopicki, Anna Hänle, Miriam Barthelmess, Jan Meyer, Dušan Turk, N. Werner, Thomas A. White, Boris Krichel, Winfried Hinrichs, F. Trost, Sebastian Günther, Filip Guicking, Vasundara Srinivasan, Alke Meents, Gisel E. Peña Murillo, Maria Marta Garcia Alai, Huijong Han, Arwen R. Pearson, Holger Fleckenstein
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health problems and economical challenges for mankind. To date, no effective drug is available to directly treat the disease and prevent virus spreading. In a search for a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78d640669dec95efad943e6c0a02e329
https://doi.org/10.1101/2020.11.12.378422
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9
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
Autor: Yaiza Fernández-García, Dominik Oberthuer, Christian Betzel, Tobias Beck, Markus Wolf, Kristina Lorenzen, M. Domaracky, Bruno Alves Franca, Jo J. Zaitsev-Doyle, Dušan Turk, Hévila Brognaro, Arwen R. Pearson, Henry N. Chapman, Jan Meyer, Robin Schubert, Stephan Günther, M. Galchenkova, Eike C. Schulz, B. Seychell, Manfred S. Weiss, H. Andaleeb, Aida Rahmani Mashhour, Y. Gevorkov, Sven Falke, Pedram Mehrabi, V. Hennicke, Beatriz Escudero-Pérez, Xinyuanyuan Sun, Juraj Knoska, Linlin Zhang, S. Meier, J. Pletzer-Zelgert, Holger Fleckenstein, N. Ullah, Rolf Hilgenfeld, Oleksandr Yefanov, Cromarte Rogers, Henry Gieseler, Thomas J. Lane, Ariana Peck, Alke Meents, C. Schmidt, J. Wollenhaupt, J. Lieske, Huijong Han, Helen M. Ginn, Bernhard Ellinger, Diana C. F. Monteiro, Christiane Ehrt, Pontus Fischer, Illona Dunkel, F. Trost, Luca Gelisio, Sebastian Günther, A. Tolstikova, Faisal Hammad Mekky Koua, Gisel Esperanza, D. Melo, Christian G. Feiler, Matthias Rarey, Andrea Zaliani, P. Reinke, M. Schwinzer, Russell J. Cox, Heshmat Noei, Salah Awel, N. Werner, Boris Krichel, Charlotte Uetrecht, Ashwin Chari, P. Gribbon, P. Lourdu Xavier, W. Brehm, S. Saouane, M. Groessler, Brenna Norton-Baker, Frank Schlünzen, Chufeng Li, Henning Tidow, Maria Kuzikov, Johanna Hakanpää, Miriam Barthelmess, Thomas A. White, Filip Guicking
Publikováno v: Zenodo (2020). doi:10.1101/2020.05.02.043554
Here we present the crystal structure of SARS-CoV-2 main protease (Mpro) covalently bound to 2-methyl-1-tetralone. This complex was obtained by co-crystallization of Mpro with HEAT (2-(((4-hydroxyphenethyl)amino)methyl)-3,4-dihydronaphthalen-1(2H)-on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad748548ca306603280bbd7e9f68a2fe
https://hdl.handle.net/21.11116/0000-0006-61B1-421.11116/0000-0006-61B3-2
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10
Serial protein crystallography in an electron microscope
Autor: Y. Gevorkov, R. J. Dwayne Miller, Pedram Mehrabi, Robert Bücker, Eike C. Schulz, Oleksandr Yefanov, Günther Kassier, Lindsey A. Bultema, Dominik Oberthür, W. Brehm, Pascal Hogan-Lamarre
Publikováno v: Nature Communications (11) 996 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications 11(1), 996 (2020). doi:10.1038/s41467-020-14793-0
Serial X-ray crystallography at free-electron lasers allows to solve biomolecular structures from sub-micron-sized crystals. However, beam time at these facilities is scarce, and involved sample delivery techniques are required. On the other hand, ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ad06a60188b2c4082fdf54ed689cd6
https://hdl.handle.net/11420/5387
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