Výsledky vyhledávání - "W. Borkowski"

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Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain.

Autor: Walker S Jackson, Clemens Krost, Andrew W Borkowski, Lech Kaczmarczyk

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95958 (2014)

Prion diseases induce neurodegeneration in specific brain areas for undetermined reasons. A thorough understanding of the localization of the disease-causing molecule, the prion protein (PrP), could inform on this issue but previous studies have gene

Externí odkaz: https://doaj.org/article/27d8713a470f4f3e94e5a1e3414124d4

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Akademický článek

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Akademický článek

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Toll-Like Receptor 3 Activation Is Required for Normal Skin Barrier Repair Following UV Damage

Autor: Jamie J. Bernard, I-Hsin Kuo, Benjamin D. Yu, Lisa A. Beck, Richard L. Gallo, Michael R. Williams, Takeshi Yoshida, Nai-Jung Hung, Andrew W. Borkowski

Publikováno v: The Journal of investigative dermatology, vol 135, iss 2

UV damage to the skin leads to the release of noncoding RNA (ncRNA) from necrotic keratinocytes that activates Toll-like receptor 3 (TLR3). This release of ncRNA triggers inflammation in the skin following UV damage. Recently, TLR3 activation was als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df9be9be3d82ea80789e7f0346cf463

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IL-1 Receptor-Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response after Exposure to UVB Radiation

Autor: Christopher A. Adase, Ling-juan Zhang, Richard L. Gallo, Nikhil Nitin Kulkarni, Arup K. Indra, Daniel J. Coleman, Carlos Aguilera, Fengwu Li, James A. Sanford, Andrew W. Borkowski

Publikováno v: The Journal of investigative dermatology. 137(11)

In this study, we observed that mice lacking the IL-1 receptor (IL-1R) ( IL1r –/– ) or deficient in IL1-β developed multiple epidermal cysts after chronic UVB exposure. Cysts that developed in IL1r –/– mice were characterized by the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2824b6721f0731cd3276f4e9891ed87f
https://pubmed.ncbi.nlm.nih.gov/28754339

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Ruxolitinib, a JAK1/JAK2 Selective Inhibitor Is Highly Efficacious in Corticosteroid Untreated and Refractory MHC-Mismatched Mouse Model of Acute GvHD

Autor: Bruce Ruggeri, Sindy Condon, Ashish Juvekar, Paul Smith, Andrew W. Borkowski, Reid Huber

Publikováno v: Blood. 132:4523-4523

Introduction: Graft-versus-host disease (GvHD) is a severe complication arising in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Potent and selective modulation of JAK/STAT-mediated signaling is an attractive the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52091556054d62e13e5f53a5e16f495d
https://doi.org/10.1182/blood-2018-99-112223

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Itacitinib, a JAK1 Selective Inhibitor Preserves Graft-Versus-Leukemia (GVL), Enhances Survival and Is Highly Efficacious in a MHC-Mismatched Mouse Model of Acute GvHD

Autor: Ashish Juvekar, Andrew W. Borkowski, Reid Huber, Paul Smith, Sindy Condon, Bruce Ruggeri

Publikováno v: Blood. 132:4522-4522

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa4aeed81f418d84d0d631c23395e69
https://doi.org/10.1182/blood-2018-99-112144

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Non-coding Double-stranded RNA and Antimicrobial Peptide LL-37 Induce Growth Factor Expression from Keratinocytes and Endothelial Cells*

Autor: Emi Sato, Christopher A. Adase, Ling-juan Zhang, Richard L. Gallo, Michael R. Williams, James A. Sanford, Andrew W. Borkowski

Publikováno v: The Journal of biological chemistry, vol 291, iss 22

A critical function for skin is that when damaged it must simultaneously identify the nature of the injury, repair barrier function, and limit the intrusion of pathogenic organisms. These needs are carried out through the detection of damage-associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d83a62694e5aa7142eb171a6a43fce
https://europepmc.org/articles/PMC4882433/

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Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

Autor: Benjamin D. Yu, Eric L. Greidinger, Beda Muehleisen, Jamie J. Bernard, Teruaki Nakatsuji, Jun Muto, Richard L. Gallo, Laisel Martinez, Andrew W. Borkowski, Christopher Cowing-Zitron

Publikováno v: Nature Medicine. 18:1286-1290

Exposure to ultraviolet B (UVB) radiation from the sun can result in sunburn, premature aging and carcinogenesis, but the mechanism responsible for acute inflammation of the skin is not well understood. Here we show that RNA is released from keratino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24d4c38512b8100bceba210b892684d
https://doi.org/10.1038/nm.2861

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