Výsledky vyhledávání - "W. Boersma-van Ek"

Regulation of TRAIL receptor expression by -catenin in colorectal tumours

Autor: W. Boersma-van Ek, de Elisabeth G. E. Vries, Johannes Wesseling, D. M. Heijink, Jan J. Koornstra, Mathilde Jalving, Nynke Zwart, Jan H. Kleibeuker, de Steven Jong, Willem Sluiter

Publikováno v: CARCINOGENESIS, 35(5), 1092-1099. Oxford University Press

Expression of the pro-apoptotic TRAIL receptors is regulated, at least in part, by beta-catenin. We show that beta-catenin co-localizes with DR4/5 in human and mouse colorectal tumours and that downregulation of beta-catenin in cell line models reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0118da6ec498cd13d800db5d1c92325
https://doi.org/10.1093/carcin/bgt484

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Dysplasia in Fundic Gland Polyps is Associated with Nuclear β-Catenin Expression and Relatively High Cell Turnover Rates

Autor: S de Jong, Arend Karrenbeld, W. Boersma-van Ek, Jan J. Koornstra, Jan H. Kleibeuker, E.G.E. de Vries, Harry Hollema, Mathilde Jalving

Publikováno v: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38(9), 916-922. Taylor & Francis Group

Background: Fundic gland polyps (FGPs) occur in both syndromic and sporadic form. Syndromic FGPs arise through mutations in the adenomatous polyposis coli (APC) gene, whereas sporadic FGPs are caused by beta-catenin gene mutations. Dysplasia in spora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d33dbe288a1deb21a3c74c4b465883
https://doi.org/10.1080/00365520310005433

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Calcium affects biomarkers of colon carcinogenesis after right hemicolectomy

Autor: Arend Karrenbeld, W. Boersma-van Ek, Nynke Zwart, de Elisabeth G. E. Vries, B. A. P. Van Gorkom, T van der Sluis, Jan H. Kleibeuker, R. van der Meer, D. S. M. L. Termont

Publikováno v: European Journal of Clinical Investigation. 32:693-699

BACKGROUND: In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f88e3896a3515f7330882d266f17e71f
https://doi.org/10.1046/j.1365-2362.2002.01048.x

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Changes in Bile Acid Composition and Effect on Cytolytic Activity of Fecal Water by Ursodeoxycholic Acid Administration: a Placebo-Controlled Cross-over Intervention Trial in Healthy Volunteers

Autor: R. van der Meer, B. A. P. Van Gorkom, W. Boersma-van Ek, D. S. M. L. Termont, E.G.E. de Vries, Jan H. Kleibeuker

Publikováno v: Scandinavian Journal of Gastroenterology. 37:965-971

Ursodeoxycholic acid (UDCA) has been shown to affect membrane-damaging effects of bile acids in vitro and fecal bile acid composition in rats. This study evaluates the effect of UDCA on fecal bile acid composition and on cytolytic activity of fecal w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09466a774e53bc498e33e2698c605a4
https://doi.org/10.1080/003655202760230955

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Increased intestinal permeability during cytomegalovirus infection in renal transplant recipients

Autor: E. F. Maar, J. H. Kleibeuker, W. Boersma-van Ek, T. H. The, W. J. Son

Publikováno v: Transplant International, 9(6), 576-580. Wiley

Cytomegalovirus (CMV) infections in renal transplant recipients can affect the gastrointestinal trace, but significant clinical manifestations are seldom seen. We hypothesize that subclinical involvement of the gastrointestinal tract may be quite fre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ac3d616caaf0183f571c84d730f958
https://doi.org/10.1111/j.1432-2277.1996.tb00917.x

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Effects of Supplemental Dietary Calcium on Quantitative and Qualitative Fecal Fat Excretion in Man

Autor: Nh Mulder, Frits A. J. Muskiet, A. Cats, W. Boersma-van Ek, R. van der Meer, E. T. H. G. J. Oremus, E.G.E. de Vries, Jan H. Kleibeuker, J. W. M. Welberg, H. Van Rijsbergen, J. F. Monkelbaan

Publikováno v: Annals of nutrition and metabolism, 38(4), 185-191. KARGER

Oral calcium supplementation is thought to be a useful interventional agent to decrease colon cancer risk. This is supposedly due, at least in part, to the binding of bile acids and fatty acids by calcium in the colon, thus prohibiting the damaging e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9ef22f3f4e9f65721475d516ec5e31
https://doi.org/10.1159/000177810

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Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas

Autor: de Steven Jong, Mathilde Jalving, Jelle Wesseling, W. Boersma-van Ek, Jan H. Kleibeuker, D. M. Heijink, Jan J. Koornstra

Publikováno v: Cellular oncology, 29(5), 409-419. SPRINGER
Cellular Oncology, Vol 29, Iss 5, Pp 409-419 (2007)
Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
Europe PubMed Central

Background: TNF-Related Apoptosis Inducing Ligand (TRAIL) is a promising agent for the induction of apoptosis in neoplastic tissues. Important determinants of TRAIL sensitivity are two intracellular proteins of the TRAIL pathway, caspase-8 and its an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5f68b029302aecd00dca920afd0a5d
https://research.rug.nl/en/publications/3d431baf-0b38-4b55-b66a-8117271ec6ab

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Cell cycle regulators and apoptosis-associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma

Autor: F Rijcken, W. Boersma-van Ek, T van der Sluis, Jan H. Kleibeuker, Harmen Hollema, van der Ate Zee

Publikováno v: Histopathology, 48(3), 275-285. Wiley

Aims: Mismatch repair gene malfunction occurs early in the carcinogenesis of hereditary non-polyposis colorectal cancers (HNPCCs), leading to an accelerated accumulation of mutations and possibly to change in expression of cell cycle proteins. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c7293a4f5b3096cf1f52c9e6a30878
https://research.rug.nl/en/publications/ee3fb08a-fa94-4c07-96b4-03b1f1429bf0

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Calcium affects biomarkers of colon carcinogenesis after right hemicolectomy

Autor: B A P, van Gorkom, R, van der Meer, A, Karrenbeld, T, van der Sluis, N, Zwart, D S M L, Termont, W, Boersma-van Ek, E G E, de Vries, J H, Kleibeuker

Publikováno v: European journal of clinical investigation. 32(9)

In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This study aims

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0285ff2471f4428a044219354b3a11dd
https://pubmed.ncbi.nlm.nih.gov/12486870

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