Zobrazeno 1 - 10
of 211
pro vyhledávání: '"W. Bair"'
Autor:
Saraswathi Vedam, Laurie Zephyrin, Pandora Hardtman, Indra Lusero, Rachel Olson, Sonia S. Hassan, Nynke van den Broek, Kathrin Stoll, Paulomi Niles, Keisha Goode, Lauren Nunally, Remi Kandal, James W. Bair
Publikováno v:
Maternal and child health journal. 26(4)
Inequities in birth outcomes are linked to experiential and environmental exposures. There have been expanding and intersecting wicked problems of inequity, racism, and quality gaps in childbearing care during the pandemic. We describe how an intenti
Autor:
Zhongguo Wang, Goss Stryker Kauffman, Stephen Hubbs, Shawn Fessler, Lili Yao, Jennifer Castro, George P. Luke, Lu Wei, Mark T. Kershaw, Matthew W. Martin, Shawn Schiller, Crystal McKinnon, Angela V. Toms, Kenneth W. Bair, David S. Millan, David R. Lancia, Deepali Gotur, Li Hongbin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1001-1006
The discovery, structure-activity relationships, and optimization of a novel class of fatty acid synthase (FASN) inhibitors is reported. High throughput screening identified a series of substituted piperazines with structural features that enable int
Publikováno v:
IWC Journal of Cetacean Research and Management. 20:101-109
Given the difficulties and costs often associated with surveying cetaceans, enlisting members of the public to collect data offers a promisingalternative approach. Comparison of cetacean ‘participatory science’ (also known as ‘citizen science
Autor:
Weiru Wang, Kristi Elkins, Angela Oh, Yen-Ching Ho, Jiansheng Wu, Hong Li, Yang Xiao, Mandy Kwong, Mary Coons, Bobby Brillantes, Eric Cheng, Lisa Crocker, Peter S Dragovich, Deepak Sampath, Xiaozhang Zheng, Kenneth W Bair, Thomas O'Brien, Lisa D Belmont
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109366 (2014)
Inhibiting NAD biosynthesis by blocking the function of nicotinamide phosphoribosyl transferase (NAMPT) is an attractive therapeutic strategy for targeting tumor metabolism. However, the development of drug resistance commonly limits the efficacy of
Externí odkaz:
https://doaj.org/article/bb7aac885fbb499794f3ed2668eeafc5
Autor:
K.J. Barr, A. Ericsson, Zhongguo Wang, David R. Lancia, A. Clarke, R.B. Diebold, S. Ashwell, George P. Luke, Deepali Gotur, Wei Lu, Jian Lin, H.R. Josephine, M. Katz, D. Walker, A.M. Campbell, Goss Stryker Kauffman, L. Yao, Angela V. Toms, Caravella Justin Andrew, H. Diep, Jennifer Castro, Kenneth W. Bair, E. Fritzen, Christopher J. Dinsmore, Stephen Hubbs, Le Wang, G.R. Gustafson, Tatiana E. Shelekhin, Mark T. Kershaw
Publikováno v:
Journal of medicinal chemistry. 62(14)
Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers. Inhibition of mutant IDH1 (mIDH1) with small molecules has been clinically validated as a promising therapeutic treatmen
Akademický článek
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Autor:
Bianca M. Liederer, Xiaozhang Zheng, Kenneth W. Bair, Yen-Ching Ho, Timm Baumeister, Nicholas J. Skelton, Leslie Wang, Weiru Wang, Thomas O'Brien, Lei Zhang, Jason Oeh, Yuen Po-Wai, Yongbo Liu, Peter S. Dragovich, Deepak Sampath, Yang Xiao, Xiongcai Liu, Mark Zak, Hongxing Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4875-4885
Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determ
Autor:
Janet Gunzner-Toste, Maureen Caligiuri, Nicholas J. Skelton, Jian Lin, Sophie Mukadam, Weiru Wang, Paul Bauer, Kenneth W. Bair, Xiaozhang Zheng, Karl H. Clodfelter, Bianca M. Liederer, Bang Fu, Thomas O'Brien, Zhongguo Wang, Peter S. Dragovich, Jasleen K. Sodhi, Lei Zhang, Geeta Sharma, Yen-Ching Ho, Chase C. Smith, Dominic J. Reynolds, Bingsong Han, Alexandre J. Buckmelter, Timm Baumeister, Angela Oh, Guiling Zhao, Nikolai Kley, Xiaorong Liang, Yang Xiao, Yuen Po-Wai, Mark Zak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3531-3538
Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. This unwanted property was successfully removed from the described inhibitors t
Autor:
Xiongcai Liu, Yuen Po-Wai, Deepak Sampath, Thomas O'Brien, Jasleen K. Sodhi, Lei Zhang, Nicholas J. Skelton, Weiru Wang, Yen-Ching Ho, Jason Oeh, Yang Xiao, Rongbao Hua, Mark Zak, Snahel Patel, Peter S. Dragovich, Kenneth W. Bair, Bianca M. Liederer, Xiaozhang Zheng, Yunli Wang, Guiling Zhao
Publikováno v:
Journal of medicinal chemistry. 59(18)
NAMPT inhibitors may show potential as therapeutics for oncology. Throughout our NAMPT inhibitor program, we found that exposed pyridines or related heterocyclic systems in the left-hand portion of the inhibitors are necessary pharmacophores for pote
Autor:
Stewart, W. Bair (AUTHOR)
Publikováno v:
American Economic Review. May46, Vol. 36 Issue 2, p36-51. 16p.