Výsledky vyhledávání - "W. B. Ruzicka"

GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability

Autor: Ekrem Maloku, Dennis R. Grayson, W. B. Ruzicka, Ying Chen, Rosalba Satta, Alessandro Guidotti, Erbo Dong, Marin Veldic, Erminio Costa, Marija Kundakovic, Adrian Zhubi

Publikováno v: Expert Review of Neurotherapeutics. 9:87-98

The neuronal GABAergic mechanisms that mediate the symptomatic beneficial effects elicited by a combination of antipsychotics with valproate (a histone deacetylase inhibitor) in the treatment of psychosis (expressed by schizophrenia or bipolar disord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a395c00f748cf3053000da677032d72d
https://doi.org/10.1586/14737175.9.1.87

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Reviewing the Role of DNA (Cytosine-5) Methyltransferase Overexpression in the Cortical GABAergic Dysfunction Associated with Psychosis Vulnerability

Autor: Erbo Dong, Dennis R. Grayson, W. B. Ruzicka, Erminio Costa, Alessandro Guidotti, Marin Veldic

Publikováno v: Scopus-Elsevier

In this review, we discuss changes in the regulation of gene expression in the central nervous system (CNS) associated with DNA (cytosine-5) methylation, chromatin remodeling and post-translational covalent modifications of histones. During brain dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeae6e1d941dac8c53e23289bb41d38
https://doi.org/10.4161/epi.2.1.4063

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S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis

Autor: Alessandro Guidotti, Dennis R. Grayson, W. B. Ruzicka, John M. Davis, Erminio Costa, Graziano Pinna, Marin Veldic

Publikováno v: NeuroReport. 18:57-60

Prefrontal cortex (Brodmann's area 9) levels of the methyl donor S-adenosyl methionine were increased by about two-fold in schizophrenia and bipolar disorder patients, but not in unipolar depressed patients compared with nonpsychiatric subjects from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8d797f5f279f63c172874f4d8c0c15
https://doi.org/10.1097/wnr.0b013e32800fefd7

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An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

Autor: Alessandro Guidotti, Patricia Tueting, Ikuko Sugaya, Lucio Tremolizzo, Rajiv P. Sharma, G. Carboni, Dennis R. Grayson, W. B. Ruzicka, Colin P. Mitchell, Erminio Costa

Publikováno v: Proceedings of the National Academy of Sciences. 99:17095-17100

Reelin and glutamic acid decarboxylase (GAD) 67 expressed by cortical γ-aminobutyric acid-ergic interneurons are down-regulated in schizophrenia. Because epidemiological studies of schizophrenia fail to support candidate gene haploinsufficiency of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8f551a98dde9cef4b85b821c939314
https://doi.org/10.1073/pnas.262658999

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DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients

Autor: Alessandro Guidotti, Dennis R. Grayson, W. B. Ruzicka, Erbo Dong

Publikováno v: Schizophrenia research. 167(1-3)

The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated with overexpression of DNA methyltransferase1 (DNMT1) and ten-eleven trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa89a475ff3c757e2cacff4f4fa2f87a
https://pubmed.ncbi.nlm.nih.gov/25476119

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Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model

Autor: A J Coleman, Sivan Subburaju, W. B. Ruzicka, Francine M. Benes

Publikováno v: Translational Psychiatry

Schizophrenia (SZ) is associated with GABA neuron dysfunction in the hippocampus, particularly the stratum oriens of sector CA3/2. A gene expression profile analysis of human postmortem hippocampal tissue followed by a network association analysis ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6d11080ef6d2d235849cec6a8ef03d
https://doi.org/10.1038/tp.2015.224

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Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection

Autor: Marin Veldic, Dennis R. Grayson, W. B. Ruzicka, Alessandro Guidotti, Adrian Zhubi, Erminio Costa

Publikováno v: Molecular psychiatry. 12(4)

Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hyper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865eb5e0f6adaeb1e495b72e5860e34
https://pubmed.ncbi.nlm.nih.gov/17264840

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Epigenetic Targets in GABAergic Neurons to Treat Schizophrenia

Autor: Erminio Costa, Erbo Dong, Marin Veldic, M. V. Simonini, Dennis R. Grayson, W. B. Ruzicka, Alessandro Guidotti

Publisher Summary This chapter describes the epigenetic targets in γ‐aminobutyric acid (GABAergic) neurons to treat schizophrenia (SZ). In the cortical GABAergic neurons of SZ patients, transcriptional downregulation of genes, encoding several pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6459c7809a66d435254f7d524c695cfe
https://doi.org/10.1016/s1054-3589(06)54005-0

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