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Objective measurement of activation of rigidity: diagnostic, pathogenetic and therapeutic implications in parkinsonism

Autor: R. Kosik, C. J. A. O'Neill, Andre Charlett, K. Mozol, P. W. Nicholson, A. G. Purkiss, R. J. Dobbs, S. G. Bowes, W. B. Hunt, S. M. Dobbs, C. Weller, C. Kirollos

1. Quantification of the effect on rigidity of its 'activation', by isometric grip, of standardized pressure, of the contralateral hand, was explored. Torque required to move the forearm through a fixed angle of 40 degrees, at a controlled rate of 0.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2242e028f620690c51379e144504897e
https://europepmc.org/articles/PMC2042619/

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Time course of physical and psychological responses to selegiline monotherapy in newly diagnosed, idiopathic parkinsonism

Autor: W. B. Hunt, S. G. Bowes, A. G. Purkiss, R. J. Dobbs, A. Charlett, C. Kirollos, J. Dickins, G. Faulkner, C. Weller, S. M. Dobbs, P. W. Nicholson, C. J. A. O'Neill

Publikováno v: European journal of clinical pharmacology. 50(1-2)

Poor specificity of face-value endpoints and the poor sensitivity of gross clinical examination may have militated against demonstrating prophylaxis by selegiline.Objective measures of the four cardinal signs were used as primary outcome criteria in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293b24ff973b9b0942a565b92d8bc54f
https://pubmed.ncbi.nlm.nih.gov/8739805

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Quantification of the cardinal signs of parkinsonism and of associated disability in spouses of sufferers

Autor: C. J. A. O'neill, S. G. Bowes, A. G. Purkiss, R. J. Dobbs, W. B. Hunt, Andre Charlett, S. M. Dobbs, C. Kirollos, Clive Weller

Publikováno v: Age and ageing. 22(1)

Work on the causation of idiopathic parkinsonism is limited by relying on gross clinical definition and lack of studies in the old. A prognostic index for parkinsonism, based on hypo/bradykinesia of gait, had considerably higher values in spouses of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e9f91ae2c55ea68f2485909d6683d2
https://pubmed.ncbi.nlm.nih.gov/8438661

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Evaluation of the safety of enalapril in the treatment of heart failure in the very old

Autor: C. J. A. O'neill, S. M. Dobbs, J. P. Royston, W. B. Hunt, R. J. Dobbs, M. J. Denham, S. G. Bowes, C. M. Sullens

Publikováno v: European Journal of Clinical Pharmacology. 35:143-150

We have introduced enalapril, in doses equal to or less than the 2.5 mg currently recommended, as an adjuvant to digoxin and diuretics in 17 patients of mean (SD) age 83 (5) years with severe heart failure. Only eleven patients tolerated its introduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a044a374a15e107cd5be103cb2d60be8
https://doi.org/10.1007/bf00609243

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