Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress

Autor: W. Alfredo Ríos-Ocampo, Toos Daemen, Manon Buist-Homan, Klaas Nico Faber, María-Cristina Navas, Han Moshage

Publikováno v: Redox Report, Vol 24, Iss 1, Pp 17-26 (2019)

Objectives: The occurrence of oxidative stress and endoplasmic reticulum (ER) stress in hepatitis C virus (HCV) infection has been demonstrated and play an important role in liver injury. During viral infection, hepatocytes must handle not only the r

Externí odkaz: https://doaj.org/article/5bb5d5c796404136bec2ee774b35321e

Mutations in the V-ATPase Assembly Factor VMA21 Cause a Congenital Disorder of Glycosylation With Autophagic Liver Disease

Autor: Elzbieta Czarnowska, Magda Cannata Serio, Pavel Pichurin, Sharita Timal, Jos C. Jansen, Hannu Kalimo, Adriaan G. Holleboom, Can Ficicioglu, Margret Ryan, Johan W. Jonker, Richard J. Rodenburg, Linda Hasadsri, Angel Ashikov, Christian Gilissen, Miao He, W. Alfredo Ríos-Ocampo, Matias Simons, Lars E. Larsen, Dirk Lefeber, Berge A. Minassian, Alessandra Rugierri, Joris A. Veltman, Tom H. Stevens, Gwenn Le Meur, Eva Morava, Piotr Socha, Kimiyo Raymond, Laurie A. Graham

Publikováno v: Hepatology (Baltimore, Md.)
Hepatology (Baltimore, Md.), 72(6), 1968-1986. John Wiley and Sons Ltd
Hepatology, 72, 6, pp. 1968-1986
Hepatology, 72(6), 1968-1986. Wiley
Hepatology, 72, 1968-1986
Hepatology

Background and Aims Vacuolar H+-ATP complex (V-ATPase) is a multisubunit protein complex required for acidification of intracellular compartments. At least five different factors are known to be essential for its assembly in the endoplasmic reticulum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db692db53432f9043d5a54c01ef20dcb
https://hdl.handle.net/2066/230139

Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation after eIF2α/ATF4 Pathway Activation

Autor: Klaas Nico Faber, Toos Daemen, Han Moshage, W Alfredo Ríos-Ocampo, María Cristina Navas, Manon Buist-Homan

Publikováno v: Viruses, Vol 12, Iss 425, p 425 (2020)
Viruses
Viruses, 12(4):425. MDPI AG
Volume 12
Issue 4

Hepatitis C virus (HCV) infection is accompanied by increased oxidative stress and endoplasmic reticulum stress as a consequence of viral replication, production of viral proteins, and pro-inflammatory signals. To overcome the cellular stress, hepato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c9e03777b0e16c4bdb238c1f77f2bc
https://www.mdpi.com/1999-4915/12/4/425