Zobrazeno 1 - 10
of 10
pro vyhledávání: '"W. Alexander Stinson"'
Autor:
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W. Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S. Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N. Artyomov, David C. Schultz, P. Toby Coates, Elisha D. O. Roberson, Yasmine Belkaid, Roger A. Greenberg, Sara Cherry, Michaela U. Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J. Miner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominan
Externí odkaz:
https://doaj.org/article/ca3eac3b209b443bb4c3882b9c20a335
Autor:
W. Alexander Stinson, Cathrine A. Miner, Fang R. Zhao, Annena Jane Lundgren, Subhajit Poddar, Jonathan J. Miner
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and fibrosis. Mice with STING gain-of-function mutations (SAVI mice) develop αβ T
Externí odkaz:
https://doaj.org/article/a4c4e4bbfe444775954246d3e433d51c
Publikováno v:
Journal of Biological Chemistry. :104866
Autor:
W. Alexander Stinson, Cathrine A. Miner, Fang R. Zhao, Annena Jane Lundgren, Subhajit Poddar, Jonathan J. Miner
Publikováno v:
JCI insight. 7(17)
STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and fibrosis. Mice with STING gain-of-function mutations (SAVI mice) develop αβ T
Autor:
W. Alexander Stinson, Elizabeth A. Kennedy, Derek J. Platt, Wei Qian, Lawrence A. Schriefer, Jonathan J. Miner, Stefan T. Peterson, Dylan Lawrence, Rachel Rodgers, Amber M. Menos, Megan T. Baldridge, Cathrine A. Miner
Publikováno v:
Cell reports
SUMMARY STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans and mice with STING gain-of-function mutations develop a syndrome known as STING-associated vasculopathy with onset in infancy (SAVI), whic
Autor:
Wei Cao, Zhanguo Li, Huihui Yuan, Yuxuan Du, W. Alexander Stinson, Junhui Jia, Yulong Tong, Menglin Niu, Weiwei Lou, Shentao Li, Wentong Mei, Wenming Zhao
Publikováno v:
Advanced Healthcare Materials. 5:2911-2921
Peptide-based therapy, such as modified peptides, has attracted increased attention. IL-17 is a promising therapeutic target for autoimmune diseases, and levels of circulating bioactive IL-17 are associated with rheumatoid arthritis severity. In this
Autor:
Ray A. Ohara, Alisa E. Koch, M. Asif Amin, Takeo Isozaki, Phillip L. Campbell, David A. Fox, W. Alexander Stinson, Martin O'Brien, Qiang Shu, Pei-Suen Tsou, Jeffrey H. Ruth
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regulation of inflammation and angio
Autor:
Takeo Isozaki, Alisa E. Koch, Phillip L. Campbell, W. Alexander Stinson, Christine M. Ha, Pei-Suen Tsou, Mohammad A. Amin, Steven E. Domino, Jeffrey H. Ruth
Publikováno v:
Arthritis & Rheumatology. 66:2047-2058
Objective To determine the role of α(1,2)-linked fucosylation of proteins by fucosyltransferase 1 (FUT1) in rheumatoid arthritis (RA) angiogenesis. Methods Analysis of α(1,2)-linked fucosylated proteins in synovial tissue (ST) samples was performed
Evidence for citrullinated inhibitor of DNA binding 1 as a novel autoantigen in rheumatoid arthritis
Autor:
Ray A Ohara, Gautam Edhayan, Henriette A Remmer, Rachel L Morgan, M Asif Amin, W Alexander Stinson, Jerry Graham, Josh S Kim, Phillip L Campbell, Ali S Arbab, David A Fox, Jeffrey H Ruth
Publikováno v:
The Journal of Immunology. 196:188.12-188.12
Inhibitor of DNA binding 1 (Id1) is a nuclear transcription factor that is primarily fibroblast derived with elevated expression in rheumatoid arthritis (RA) synovial tissues (STs) and synovial fluids (SFs). Id1 is potently angiogenic in RA, and targ
Autor:
G. Kenneth Haines, Gautam Edhayan, Takeo Isozaki, Sean C. Friday, Rachel Morgan, David A. Fox, Ali S. Arbab, Christine M. Ha, Ray A. Ohara, Phillip L. Campbell, M. Asif Amin, Jeffrey H. Ruth, W. Alexander Stinson
Publikováno v:
Arthritis Research & Therapy
Background Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis