Zobrazeno 1 - 10 of 10 pro vyhledávání: '"W. A. Schmalix"'
1
Inhibition of cytochromes P4501A by nitric oxide
Autor: J R Siewert, Johannes Doehmer, T. Brill, W. A. Schmalix, J. Trockfeld, H Greim, J. Stadler
Publikováno v: Proceedings of the National Academy of Sciences. 91:3559-3563
Inflammatory stimulation of the liver leads to the induction of nitric oxide (NO) biosynthesis. Because NO binds to the catalytic heme moiety of cytochromes P450 (CYPs), we investigated whether NO interferes with specific CYP-dependent metabolic path
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12da049ed1d280b780ae3a1e7e01abe7
https://doi.org/10.1073/pnas.91.9.3559
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2
Synthetic urokinase inhibitors as potential anti-invasive drugs
Autor: J, Stürzebecher, A, Schweinitz, W A, Schmalix, P, Wikström
Publikováno v: IDrugs : the investigational drugs journal. 4(6)
In carcinogenesis, proteinases play an important role in metastasis of solid malignant tumors. Aside from several matrix metalloproteinases and cathepsins, the urokinase-plasmin system seems to be one of the main players within the cell surface-assoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::329e3a2a73fe2331e29c7484d2c8a3f8
https://pubmed.ncbi.nlm.nih.gov/16001312
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3
Towards gene therapy of cystic fibrosis
Autor: J, Rosenecker, W A, Schmalix, D, Schindelhauer, C, Plank, D, Reinhardt
Publikováno v: European journal of medical research. 3(3)
Numerous gene mutations associated with hereditary disorders have been identified. In cystic fibrosis the hereditary defect is attributed to mutations in one single gene, the gene coding for the cystic fibrosis transmembrane conductance regulator (CF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a59b7c24f2ac1f08b3899f31c13ec7b9
https://pubmed.ncbi.nlm.nih.gov/9502755
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4
Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines
Autor: W A, Schmalix, D, Lang, A, Schneider, R, Bocker, H, Greim, J, Doehmer
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(12)
V79 Chinese hamster cell lines were genetically engineered for the stable expression of human NADPH-cytochrome P450 oxidoreductase (CYPOR) alone or for the combined expression of CYPOR and human cytochrome P450 1A2 (CYP1A2). As determined by immunobl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a8a0d956816d1441c38aa53132a8d5b
https://pubmed.ncbi.nlm.nih.gov/8971136
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7
Genetically engineered in vitro systems for biotransformation studies
Autor: J, Doehmer, W A, Schmalix, H, Greim
Publikováno v: Methods and findings in experimental and clinical pharmacology. 16(7)
In order to understand cytochrome P450-mediated metabolism of xenobiotics such as drugs and pollutants, several cell systems are genetically engineered for metabolic competence by cloning cDNAs encoding cytochrome P450 and other enzymes and by hetero
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::612f1e20e334ed273a2b43ba04661e23
https://pubmed.ncbi.nlm.nih.gov/7885078
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8
Die hepatozelluläre Insuffizienz in der Sepsis: Stickoxid inhibiert den Entgiftungsstoffwechsel der Cytochrom P450 Enzyme
Autor: T. Brill, J. Stadler, J. Döhmer, W. A. Schmalix, J. Trockfeld
Publikováno v: Chirurgisches Forum ’94 ISBN: 9783540578468
Die Leberzellinsuffizienz ist im Rahmen des Multiorganversagens der Sepsis ein Problem von groser klinischer Relevanz. Charakteristische Merkmale sind die Suppression der Syntheseleistung und eine massive Inhibition des Entgiftungsstoffwechsels der L
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6dd56d0b45a3f77a4f4d920738ea8aa
https://doi.org/10.1007/978-3-642-78905-2_5
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9
A phase I, first-in-human single ascending dose study of the MEK inhibitor WX-554 given to healthy male subjects
Autor: M. Buergle, N. G. Neville, C. Mala, W. A. Schmalix, E. Haindl, P. Bevan
Publikováno v: Journal of Clinical Oncology. 28:e13666-e13666
e13666 Background: WX-554 is a small molecule inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2). The Ras/Raf/MEK/ERK pathway is one of the major signal transduction pathwa...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb1d484d7914e42eae67c87d56a02aa
https://doi.org/10.1200/jco.2010.28.15_suppl.e13666
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10
A Phase I pharmacokinetic (PK) study of single dose oral therapy with a uPA inhibitor (WX-671)
Autor: N. G. Neville, P. Bevan, M. Buergle, C. Mala, W. A. Schmalix
Publikováno v: Journal of Clinical Oncology. 24:13091-13091
13091 Background: WX-671 is an orally available prodrug of WX-UK1, a serine protease inhibitor that inhibits uPA as well as other serine proteases. WX-UK1 (Setyono-Han et al., Thromb Haemost 2005) and WX-671 have shown to efficiently reduce primary t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd34e85b903820ce8130418752d96f74
https://doi.org/10.1200/jco.2006.24.18_suppl.13091
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