Zobrazeno 1 - 10
of 1 071
pro vyhledávání: '"W. Hein"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionArylamine N-acetyltransferase 2 (NAT2) expresses a well-defined genetic polymorphism in humans that modifies drug and xenobiotic metabolism. Recent studies and genome wide association studies have reported that genetic variants of NAT2 ar
Externí odkaz:
https://doaj.org/article/4175c5e31b5e4fdc84cf8a99ae730b1c
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Arylamine N-acetyltransferase 2 (NAT2) is a phase II metabolic enzyme, best known for metabolism of aromatic amines and hydrazines. Genetic variants occurring in the NAT2 coding region have been well-defined and are known to affect the enzyme activit
Externí odkaz:
https://doaj.org/article/3eae20c69c6d4ce1aad7b6ce9110551a
Autor:
Kyung U. Hong, Jonathan Q. Gardner, Mark A. Doll, Marcus W. Stepp, Daniel W. Wilkey, Frederick W. Benz, Jian Cai, Michael L. Merchant, David W. Hein
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1566-1573 (2022)
Previous studies have shown that inhibition or depletion of N-acetyltransferase 1 (NAT1) in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast cancer cells. To un
Externí odkaz:
https://doaj.org/article/14d38dbd1a6144afb9a6d281a22dfd77
Autor:
Kyung U. Hong, Jonathan Q. Gardner, Mark A. Doll, Marcus W. Stepp, Daniel W. Wilkey, Frederick W. Benz, Jian Cai, Michael L. Merchant, David W. Hein
Publikováno v:
Data in Brief, Vol 45, Iss , Pp 108634- (2022)
Arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. An unbiased analysis of proteomes of parental MDA-MB-231 breast cancer cells and two separate NAT1 knockout (KO) cell lines were performed. Among 4,890 proteins identi
Externí odkaz:
https://doaj.org/article/9640105bd1f2402aab174ae3aecdec59
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
N-acetyltransferase 1 (NAT1) is a xenobiotic metabolizing enzyme that uses acetyl coenzyme A (AcCoA) as a cofactor for N-acetylation of many carcinogens including aromatic amines and alkylanilines. NAT1 is characterized by single nucleotide polymorph
Externí odkaz:
https://doaj.org/article/7f10bad8b38b46a485d4315ac10b83a4
Autor:
Guenter W. Hein
Publikováno v:
Satellite Navigation, Vol 1, Iss 1, Pp 1-12 (2020)
Abstract This paper reviews the status of satellite navigation (as per 11 May 2020)—without claim for completeness—and discusses the various global navigation satellite systems, regional satellite navigation systems and satellite-based augmentati
Externí odkaz:
https://doaj.org/article/c39a8e3cb5004f0dad72a163f2ece8a7
Autor:
Mark A. Doll, David W. Hein
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). Gen
Externí odkaz:
https://doaj.org/article/1dad4adfa9a94106ba20a3a34b3ae2a3
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Arylamine N-acetyltransferases catalyze the transfer of acetyl groups from the endogenous cofactor acetyl coenzyme A (AcCoA) to arylamine (N-acetylation) and N-hydroxy-arylamine (O-acetylation) acceptors. Humans express two arylamine N-acetyltransfer
Externí odkaz:
https://doaj.org/article/d6d64a673dec48abb8bd7014749e6a31
Autor:
Islamiat Oladipupo, T'shura Ali, David W Hein, Kelly Pagidas, Henry Bohler, Mark A Doll, Merry Lynn Mann, Adrienne Gentry, Jasmine L Chiang, Rebecca C Pierson, Sashia Torres, Emily Reece, Kira C Taylor
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278998 (2022)
IntroductionThis study examined the association of smoking with ovarian reserve in a cross-sectional study of 207 women enrolled in the Louisville Tobacco Smoke Exposure, Genetic Susceptibility, and Infertility (LOUSSI) Study and assessed effect modi
Externí odkaz:
https://doaj.org/article/42f4d68e679d422eb67477ac543cf3f1
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Many cancers, including breast cancer, have shown differential expression of human arylamine N-acetyltransferase 1 (NAT1). The exact effect this differential expression has on disease risk and progression remains unclear. While NAT1 is classically de
Externí odkaz:
https://doaj.org/article/91849fe6df60449a9708d1dbab6f9805