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Splenic Dendritic Cells From the Non-obese Diabetic Mouse Induce a Prolonged Proliferation of Syngeneic T Cells. A Role for an Impaired Apoptosis of NOD T cells?

Autor: Katarina Radošević, Kristina Casteels, W. Van Ewijk, Chantal Mathieu, Pieter J. M. Leenen, Hemmo A. Drexhage

Publikováno v: Journal of Autoimmunity. 13:373-382

In this study we have tried to detect abnormalities in the immunophenotype and/or function of dendritic cells from the non-obese diabetic mouse (NOD DC), that might be related to islet autoimmunity. The immunophenotype of NOD splenic DC did not show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd01dcbbecf6d828a8c214102cfbc6fa
https://doi.org/10.1006/jaut.1999.0338

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Bone marrow cellular composition in Listeria monocytogenes infected mice detected using ER-MP12 and ER-MP20 antibodies: a flow cytometric alternative to differential counting

Autor: W. van Vianen, Irma A. J. M. Bakker-Woudenberg, W. Van Ewijk, M. F. T. R. De Bruijn, Rob E. Ploemacher, Pieter J. M. Leenen, Priscilla A. Campbell

Publikováno v: Journal of Immunological Methods, 217, 27-39. Elsevier

Detailed assessment of bone marrow cellular composition is essential in the evaluation of various experimental in vivo systems, such as expression of transgenes, null mutations and stimulation of host defence in infection. Traditional morphological a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0498135e84f5376b49a3ca56ea720399
https://hdl.handle.net/1765/69878

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Induction of Apoptosis and T Helper 2 (Th2) Responses Correlates with Peptide Affinity for the Major Histocompatibility Complex in Self-reactive T Cell Receptor Transgenic Mice

Autor: W. Van Ewijk, C.I. Pearson, Hugh O. McDevitt

Publikováno v: Journal of Experimental Medicine, 185, 583-599. Rockefeller University Press
The Journal of Experimental Medicine

Multiple sclerosis is an autoimmune disease thought to be mediated by CD4+ T helper cells (Th). Experimental autoimmune encephalomyelitis is a rodent model of multiple sclerosis and has been used extensively to explore a variety of immunotherapies us

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https://doi.org/10.1084/jem.185.4.583

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High-level expression of the ER-MP58 antigen on mouse bone marrow hematopoietic progenitor cells marks commitment to the myeloid lineage

Autor: W. Van Ewijk, Walentina A. T. Slieker, A. E. M. Mayen, Rob E. Ploemacher, Pieter J. M. Leenen, Jane S. A. Voerman, M. F. T. R. De Bruijn

Publikováno v: European Journal of Immunology, 26(12), 2850-2858. Wiley-VCH

Studies on the early events in the differentiation of the nonspecific immune system require the identification and isolation of myeloid-committed progenitor cells. Using the monoclonal antibodies (mAb) ER-MP12 and ER-MP20, generated against immortali

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https://doi.org/10.1002/eji.1830261208

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Immunotherapy with monoclonal antibodies directed against the immunosuppressive domain of p15E inhibits tumour growth

Autor: W. Van Ewijk, H.F.J. (Huub) Savelkoul, M. S. Lang, E. Hovenkamp, Paul P. Knegt

Publikováno v: Clinical and Experimental Immunology 102 (1995) 3
Clinical and Experimental Immunology, 102(3), 468-475

SUMMARY Immunosuppressive retrovirus-related proteins, like p15E, are involved in tumour-associated immunosuppression. In the present study we investigated whether such proteins could be used as targets in tumour immunotherapy using MoAbs. Immunother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a16d2bcbe1682e9f3b03705dd64bfb
https://doi.org/10.1111/j.1365-2249.1995.tb03839.x

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Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

Autor: Peter Paul Platenburg, Cox Terhorst, Baoping Wang, Aliki Nichogiannopoulou, Steven J. Burakoff, W. Van Ewijk, Jose-Carlos Gutierrez-Ramos, Georg A. Holländer

Publikováno v: Nature. 373:350-353

T LYMPHOCYTES of the α/β T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events1–7. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical

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https://doi.org/10.1038/373350a0

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ER-MP12 antigen, a new cell surface marker on mouse bone marrow cells with thymus-repopulating ability: II. Thymus-homing ability and phenotypic characterization of ER-MP12-positive bone marrow cells

Autor: Dale I. Godfrey, W. Van Ewijk, J. C. M. Van Der Loo, Walentina A. T. Slieker, M. F. T. R. De Bruijn, Pieter J. M. Leenen

Publikováno v: International Immunology, 5(9), 1099-1107. Oxford University Press

In the accompanying paper we showed that six distinct subsets of bone marrow (BM) cells can be identified using the mAb ER-MP12 and ER-MP20 in two-colour immunofluorescence analysis. Upon intrathymic transfer into sublethally irradiated mice thymus-r

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https://doi.org/10.1093/intimm/5.9.1099

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Detection of Tumor-Specific Antigens in Philadelphia Chromosome Positive Leukemias

Autor: P. Ten Hacken, J van Denderen, W. Van Ewijk, P. Berendes

Publikováno v: Leukemia & Lymphoma. 11:29-32

In chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) the Ph1 chromosome (22q-) is the most frequent chromosomal aberration encountered. At the molecular level the c-abl gene from chr. 9 is translocated to the bcr gene on chr. 22.

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https://doi.org/10.3109/10428199309047859

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[Emergency psychiatry in Amsterdam: a historical case study]

Autor: W, van Ewijk, C M T, Gijsbers van Wijk

Publikováno v: Tijdschrift voor psychiatrie.

Over the past 25 years the system of centralised management of emergency psychiatry has disappeared and re-appeared. Since 2000 improvements have been made in the logistics, organisation and quality of emergency care. In the same period, however, the

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https://pubmed.ncbi.nlm.nih.gov/19067299

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Immunologic characterization of the tumor-specific bcr-abl junction in Philadelphia chromosome-positive acute lymphoblastic leukemia

Autor: T Meeuwsen, D. C. van der Plas, W. Boersma, N Zegers, Gerard Grosveld, W. Van Ewijk, J van Denderen

Publikováno v: Blood. 76:136-141

Philadelphia (Ph′)-positive acute lymphoblastic leukemia (ALL) is highly associated with two forms of chimeric bcr-abl proteins: P190bcr- abl and P210bcr-abl. Whereas P210bcr-abl also occurs in chronic myeloid leukemia, P190bcr-abl is uniquely expr

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https://doi.org/10.1182/blood.v76.1.136.136

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