Zobrazeno 1 - 10
of 16
pro vyhledávání: '"W Wallace Harrington"'
Autor:
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Externí odkaz:
https://doaj.org/article/6c250288d3cf48f0b41fe25918c4ad63
Autor:
Roger H. Brown, Carie L. Kimbrough, Jessica R Durrant, David Bailey, Catherine A. Faber, Chandikumar S. Elangbam, W. Wallace Harrington, Nikki Slocum, Tula Milliken, Lisa G. Clifton, Holly L. Jordan, Joanna C. Barton, Lawrence Yoon, Neal F. Cariello
Publikováno v:
Experimental and Toxicologic Pathology. 65:549-557
Drug-induced weight loss in humans has been associated with undesirable side effects not present in weight loss from lifestyle interventions (caloric restriction or exercise). To investigate the mechanistic differences of weight loss by drug-induced
Publikováno v:
Inflammation Research. 59:1061-1071
Introduction The peroxisome proliferator-activated receptors (PPARs) are well established to be important in modulating the fibrogenic response to liver injury. PPARγ plays a role in hepatic fibrosis, presumably by virtue of its expression in hepati
Autor:
Thalia T. Ashton, Kathleen K. Brown, Frank P. Maurio, John E. Bisi, Bonnie L. Blazer-Yost, Charity Nofziger, Kameljit K. Kalsi, David Murray, T. Aaron West, W. Wallace Harrington, Deborah L. Baines, Chari D. Smith
Publikováno v:
American Journal of Physiology-Renal Physiology. 297:F55-F62
PPARγ agonists are synthetic ligands for the peroxisome proliferator-activated receptor-γ (PPARγ). These agents have insulin-sensitizing properties but can cause fluid retention, thereby limiting their usefulness in patients at risk for cardiovasc
Autor:
W. Wallace Harrington, Diane M. Ignar, William R. Oliver, Joan G. Wilson, Jane G Binz, David C. Lobe, Christy S. Britt, Michael C. Lewis, Naphtali Milliken
Publikováno v:
PPAR Research. 2007:1-13
Activation of peroxisome proliferator-activated receptor (PPAR)α,δ, andγsubtypes increases expression of genes involved in fatty acid transport and oxidation and alters adiposity in animal models of obesity and type-2 diabetes. PPARpan agonists wh
Autor:
John C. Ulrich, Petrov Kimberly, Tiffany Carpenter, David J. Cowan, J. Darren Stuart, J. David Becherer, Eugene L. Stewart, Frank Preugschat, David N. Deaton, W. Wallace Harrington, Yu Guo, Naphtali Milliken, Barry G. Shearer, Michael R. Jeune, Istvan Kaldor, Terrence L. Smalley, Curt D. Haffner, Brad R. Henke, Rodolfo Cadilla, Todd W. Shearer, Eric E. Boros, Christie Schulte
Publikováno v:
Journal of medicinal chemistry. 58(8)
A series of thiazoloquin(az)olinones were synthesized and found to have potent inhibitory activity against CD38. Several of these compounds were also shown to have good pharmacokinetic properties and demonstrated the ability to elevate NAD levels in
Autor:
Michael C. Lewis, William R. Oliver, David C. Lobe, Jane G. Binz, Naphtali O. Milliken, Joan G. Wilson, Christy S. Britt, W. Wallace Harrington, Diane M. Ignar
Publikováno v:
PPAR Research, Vol 2007 (2007)
Publikováno v:
PPAR Research, Vol 2007 (2007)
PPAR Research
PPAR Research
Welcome to this special issue of PPAR Research dedicated to “PPARs and Obesity.” Obesity and the interrelated disorders of the metabolic syndrome are a global health epidemic. To address this major problem, it is essential to understand the mecha
Autor:
Jing Chen, Henning F. Kramer, Andrew N. Billin, Ying Qian, Guizhen Luo, Naphtali Milliken, Tiffany Carpenter, J. David Becherer, Frank Preugschat, W. Wallace Harrington, Stephen A. Stimpson, Curt D. Haffner, Shian Huey Chiang, Rusty Murray, Deepak K. Rajpal, John C. Ulrich, Robert S. Geske
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
PLoS ONE
PLoS ONE
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Autor:
Stephen A. Stimpson, Liu Yang, Oh-Sang Kwon, Jason McGhee, Che-Chang Chan, Lihong Z. Chen, Don C. Rockey, W. Wallace Harrington, William T. Symonds, Songling Liu
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 291(5)
The peroxisome proliferator-activated receptors (PPARs) impart diverse cellular effects in biological systems. Because stellate cell activation during liver injury is associated with declining PPARgamma expression, we hypothesized that its expression