Zobrazeno 1 - 10 of 31 pro vyhledávání: '"W W Hauswirth"'
2
Inhibition of gene expression by ribozymes
Autor: W W, Hauswirth, L C, Shaw, P O, Whalen, J J, Fritz, D A, White, A S, Lewin
Publikováno v: Methods in molecular medicine. 47
RNA enzymes, or ribozymes, can be defined as RNA molecules that promote a variety of reactions involving RNA and DNA molecules. These include site-specific cleavage, ligation, polymerization, and phosphoryl exchange (1). The use of ribozymes for medi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19d4b6063ebb05c464f1d7cc53d59679
https://pubmed.ncbi.nlm.nih.gov/21394581
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3
AAV retinal transduction in a large animal model species: comparison of a self-complementary AAV2/5 with a single-stranded AAV2/5 vector
Autor: S M, Petersen-Jones, J T, Bartoe, A J, Fischer, M, Scott, S L, Boye, V, Chiodo, W W, Hauswirth
Publikováno v: Molecular Vision
Purpose To compare self-complementary (sc) and single-stranded (ss) adeno-associated viral 2/5 (AAV2/5) vectors for retinal cell transduction in the dog when delivered by subretinal injection. Methods ScAAV2/5 and ssAAV2/5 vectors encoding enhanced g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e46686fc7a0960796465c9aad3ea69c
https://pubmed.ncbi.nlm.nih.gov/19756181
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4
Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse
Autor: Q, Li, A M, Timmers, K, Hunter, C, Gonzalez-Pola, A S, Lewin, D H, Reitze, W W, Hauswirth
Publikováno v: Investigative ophthalmologyvisual science. 42(12)
Optical coherence tomography (OCT) is a high-resolution imaging technique that measures the intensity of backscattered light from biological microstructures in living tissue. The objective was to evaluate OCT as a routine, noninvasive technique for q
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54bce481884495428d413855c8b96b7f
https://pubmed.ncbi.nlm.nih.gov/11687546
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5
An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa
Autor: L C, Shaw, A, Skold, F, Wong, R, Petters, W W, Hauswirth, A S, Lewin
Publikováno v: Molecular vision. 7
To develop a hammerhead ribozyme-based gene therapy for a porcine model of autosomal dominant retinitis pigmentosa (ADRP).Hammerhead ribozymes were developed and assayed in vitro against RNA targets homologous to the opsin P347S mutants found in a tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a52413bd6b1147a09c79b5430243916
https://pubmed.ncbi.nlm.nih.gov/11172137
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9
Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa
Autor: K A, Drenser, A M, Timmers, W W, Hauswirth, A S, Lewin
Publikováno v: Investigative ophthalmologyvisual science. 39(5)
To design ribozymes--catalytic RNA molecules--to cleave the P23H and S334Ter mutant mRNA selectively and to test them in vitro to determine their potential as therapeutic agents in the prevention of autosomal dominant retinitis pigmentosa.Synthetic R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ab5391aefb394c826152bf61bfb1cc0
https://pubmed.ncbi.nlm.nih.gov/9538873
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10
Developmentally important DNA elements within the bovine opsin upstream region
Autor: L E, DesJardin, W W, Hauswirth
Publikováno v: Investigative ophthalmologyvisual science. 37(1)
Nuclear run-on analysis has documented three categories of opsin gene expression during bovine fetal retinal development: basal levels of transcription occurring before 6 months gestation; opsin-specific enhanced levels of fetal transcription at 7-7.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1ccb986c60edf05a9393457eda90cfa
https://pubmed.ncbi.nlm.nih.gov/8550318
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