Zobrazeno 1 - 10
of 51
pro vyhledávání: '"W W Cruikshank"'
Publikováno v:
The Journal of Immunology. 163:3123-3130
The ability of HIV-1 gp120 to inhibit chemokine signaling prompted us to determine whether signaling through CD4 by a natural ligand, IL-16, could alter cellular responsiveness to chemokine stimulation. These studies demonstrate that IL-16/CD4 signal
Publikováno v:
The Journal of Immunology. 163:3516-3523
Hypersensitivity pneumonitis (HP) is characterized by an inflammatory lymphocytic alveolitis comprised of both CD8+ and CD4+ T cells. Animal models suggest that HP is facilitated by overproduction of IFN-γ, and that IL-10 ameliorates severity of the
Autor:
W E Biddison, R Kubota, T Kawanishi, D D Taub, W W Cruikshank, D M Center, E W Connor, U Utz, S Jacobson
Publikováno v:
The Journal of Immunology. 159:2018-2025
Human T cell leukemia virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neurologic disease characterized by marked degeneration of the spinal cord and the presence of infiltrating CD8+ T cell
Publikováno v:
The Journal of Immunology. 158:3046-3053
The demyelination process that occurs in the central nervous system of patients with multiple sclerosis (MS) is, in part, due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. Although many studies ha
Publikováno v:
The Journal of Immunology. 158:5-8
IL-16 is produced by CD8+ lymphocytes and has been reported to inhibit HIV-1 and SIV replication in infected PBMCs. CD4 serves as a receptor for the secreted form of IL-16, and IL-16 binding to CD4 induces signal transduction, which affects the activ
Publikováno v:
The Journal of Immunology. 157:1958-1964
CD4 participation in TCR/CD3-associated activation through interaction with the MHC class II Ags results in formation of a CD4-TCR/CD3 complex capable of maximal signal transduction. When CD4 binds to alternative ligands such as HIV-1 gp120 or anti-C
Publikováno v:
The Journal of Immunology. 156:310-315
At sites of inflammation, mononuclear cells are in close contact with aggregated platelets. Although the physiologic role of this association is not clear, this proximity suggests that platelet-derived mediators may play a role in chemoattraction of
Publikováno v:
The Journal of Immunology. 155:2902-2910
We have reported previously that histamine induces the release of the CD4+ cell-specific lymphocyte chemoattractant factor (LCF) into the culture supernatants of CD8+ cells between 1 and 4 h following stimulation. To determine the mechanism of histam
Publikováno v:
Proceedings of the National Academy of Sciences. 91:5109-5113
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of inte
Publikováno v:
Chest. 103:88S-91