Zobrazeno 1 - 10
of 99
pro vyhledávání: '"W W, Leung"'
Autor:
Charles Bayly-Jones, Bill H. T. Ho, Corinna Lau, Eleanor W. W. Leung, Laura D’Andrea, Christopher J. Lupton, Susan M. Ekkel, Hariprasad Venugopal, James C. Whisstock, Tom E. Mollnes, Bradley A. Spicer, Michelle A. Dunstone
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.
Externí odkaz:
https://doaj.org/article/96ef9aa75dd84880b13fa08f60261470
Autor:
A Y B, Teoh, C C N, Chong, W W, Leung, S K C, Chan, Y K, Tse, E K W, Ng, P B S, Lai, J C Y, Wu, J Y W, Lau
Publikováno v:
Hong Kong medical journal = Xianggang yi xue za zhi. 27(3)
Autor:
Maiada M. Sadek, Nicholas Barlow, Eleanor W. W. Leung, Billy J. Williams-Noonan, Beow Keat Yap, Fairolniza Mohd Shariff, Tom T. Caradoc-Davies, Sandra E. Nicholson, David K. Chalmers, Philip E. Thompson, Ruby H. P. Law, Raymond S. Norton
Publikováno v:
ACS Chemical Biology. 13:2930-2938
SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with inducible nitric oxide synthase (iNOS), causing the iNOS to be polyubiquitinated and targeted for degradation. Inhibition of this interaction increases iNOS levels, a
Publikováno v:
Techniques in coloproctology. 25(5)
Defecation is a complex process and up to 25% of the population suffer from symptoms of defecatory dysfunction. For functional testing, diagnostics, and therapy of anorectal disorders, it is important to know the optimal defecation position. is The a
Publikováno v:
Molecules, Vol 21, Iss 7, p 860 (2016)
19F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its applications include screening libraries of fluorinated fragments, assessing competition among elaborated fragments and identifying the binding poses of promising hits. By
Externí odkaz:
https://doaj.org/article/797583265b5f41d3909dd038926cd015
Autor:
James C. Whisstock, Tom T. Caradoc-Davies, Yuko Tsuda, Koushi Hidaka, Raymond S. Norton, Paul J. Conroy, Eleanor W. W. Leung, Guojie Wu, Nigel Kirby, Adam J. Quek, Ruby H. P. Law, Devadharshini Jeevarajah
Publikováno v:
Blood Advances. 1:766-771
The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemor
Autor:
Yue Yuan, Martina L. Sanderson-Smith, Adam J. Quek, Devadharshini Jeevarajah, James C. Whisstock, Ruby H. P. Law, Paul J. Conroy, Yetunde A. Ayinuola, Guojie Wu, Blake A. Mazzitelli, Eleanor W. W. Leung, Gordon J. Lloyd, Francis J. Castellino, Tom T. Caradoc-Davies
Publikováno v:
J Mol Biol
Plasminogen (Plg)-binding M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for bacterial virulence. Previous studies revealed that, by binding to the kringle 2 (KR2) domain of host Plg, the pathogen attains a proteolyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f00dd06202e8856abecac9f7d325e8c
https://europepmc.org/articles/PMC7722781/
https://europepmc.org/articles/PMC7722781/
Autor:
Martin J. Scanlon, Beow Keat Yap, Raymond S. Norton, Andrew J. Lucke, David K. Chalmers, Jonathan B. Baell, Eleanor W. W. Leung, Sandra E. Nicholson, Philip E. Thompson, Jitendra R. Harjani
Publikováno v:
Journal of Medicinal Chemistry. 59:5799-5809
SPRY domain-containing suppressor of cytokine signaling box protein (SPSB) 2-deficient macrophages have been found to exhibit prolonged expression of inducible nitric oxide synthase (iNOS) and enhanced killing of persistent pathogens, suggesting that
Autor:
James C. Whisstock, Paul J. Conroy, Eleanor W. W. Leung, Joseph A. Trapani, Hiromasa Yagi, Raymond S. Norton, Ruby H. P. Law, Ilia Voskoboinik
Publikováno v:
Journal of Biological Chemistry. 290:25213-25226
Natural killer cells and cytotoxic T-lymphocytes deploy perforin and granzymes to kill infected host cells. Perforin, secreted by immune cells, binds target membranes to form pores that deliver pro-apoptotic granzymes into the target cell. A crucial
Autor:
Raymond S. Norton, Jeffrey J. Babon, Biswaranjan Mohanty, Laura F. Dagley, Sandra E. Nicholson, James M. Murphy, Eleanor W. W. Leung, Indu R. Chandrashekaran, Edmond M. Linossi
Publikováno v:
Biochemistry. 54:4672-4682
SOCS5 can negatively regulate both JAK/STAT and EGF-receptor pathways and has therefore been implicated in regulating both the immune response and tumorigenesis. Understanding the molecular basis for SOCS5 activity may reveal novel ways to target key