Zobrazeno 1 - 10
of 117
pro vyhledávání: '"W Todd, Lowther"'
Autor:
Erin K. Hughes, Audrey Chrisman, Sandra Leone-Kabler, Glen S. Marrs, W. Todd Lowther, Allyn Howlett
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f93ae41733e836264adc47eab7ae598
https://doi.org/10.1124/jpet.122.245570
https://doi.org/10.1124/jpet.122.245570
Autor:
Tom E. Forshaw, Julie A. Reisz, Kimberly J. Nelson, Rajesh Gumpena, J. Reed Lawson, Thomas J. Jönsson, Hanzhi Wu, Jill E. Clodfelter, Lynnette C. Johnson, Cristina M. Furdui, W. Todd Lowther
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 946 (2021)
Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H2O2), the typical 2-Cys Prxs change oligomeric structure between higher order (do)decam
Externí odkaz:
https://doaj.org/article/d55fdb246166416a82421dcc5de5c96d
Autor:
Kimberly J. Nelson, Terri Messier, Stephanie Milczarek, Alexis Saaman, Stacie Beuschel, Uma Gandhi, Nicholas Heintz, Terrence L. Smalley, W. Todd Lowther, Brian Cunniff
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 150 (2021)
A central hallmark of tumorigenesis is metabolic alterations that increase mitochondrial reactive oxygen species (mROS). In response, cancer cells upregulate their antioxidant capacity and redox-responsive signaling pathways. A promising chemotherape
Externí odkaz:
https://doaj.org/article/8fd46b24ac4e4fe6b786ae1874bb76a0
Autor:
Emily E. Oliver, Erin K. Hughes, Meaghan K. Puckett, Rong Chen, W. Todd Lowther, Allyn C. Howlett
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1609 (2020)
Endocannabinoid signaling depends upon the CB1 and CB2 cannabinoid receptors, their endogenous ligands anandamide and 2-arachidonoylglycerol, and intracellular proteins that mediate responses via the C-terminal and other intracellular receptor domain
Externí odkaz:
https://doaj.org/article/a509d5d9c3f1441cb33ae19fba76deae
Publikováno v:
Molecules, Vol 24, Iss 20, p 3672 (2019)
Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid screen to modulate CB1-mediated N-type Ca2+ currents. In this paper we review studies of CRIP1a
Externí odkaz:
https://doaj.org/article/7df3cf8556be4432b015f3ab127a99ab
Autor:
Tom E. Forshaw, Reetta Holmila, Kimberly J. Nelson, Joshua E. Lewis, Melissa L. Kemp, Allen W. Tsang, Leslie B. Poole, W. Todd Lowther, Cristina M. Furdui
Publikováno v:
Antioxidants, Vol 8, Iss 1, p 11 (2019)
Peroxiredoxins have a long-established cellular function as regulators of redox metabolism by catalyzing the reduction of peroxides (e.g., H2O2, lipid peroxides) with high catalytic efficiency. This activity is also critical to the initiation and rel
Externí odkaz:
https://doaj.org/article/36d5b52f18dd47f99c6decb14159eecd
Autor:
Brian Cunniff, Kheng Newick, Kimberly J Nelson, Alexandra N Wozniak, Stacie Beuschel, Bruce Leavitt, Anant Bhave, Kelly Butnor, Andreas Koenig, Edward T Chouchani, Andrew M James, Alexina C Haynes, W Todd Lowther, Michael P Murphy, Arti Shukla, Nicholas H Heintz
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127310 (2015)
Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis through multiple mechanisms. To counteract the adverse effects of mitochondrial peroxide many
Externí odkaz:
https://doaj.org/article/80663c10267047e390e70d5eff6a490e
Autor:
Sandra Leone-Kabler, Khalil Eldeeb, W. Todd Lowther, William T. Booth, Erin K. Hughes, Jill E. Clodfelter, Allyn C. Howlett
Publikováno v:
The Journal of Biological Chemistry
Cannabinoid receptor interacting protein 1a (CRIP1a) modulates CB1 cannabinoid receptor G-protein coupling in part by altering the selectivity for Gαi subtype activation, but the molecular basis for this function of CRIP1a is not known. We report he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac35a9ef60212f1a5b6f0ec1f16cedc
http://europepmc.org/articles/PMC8446797
http://europepmc.org/articles/PMC8446797
Autor:
Ryan A. Mehl, Leslie B. Poole, Joaquín Dalla Rizza, W. Todd Lowther, Lía M. Randall, Derek Parsonage, Javier Santos, Ana Denicola
Publikováno v:
Free Radic Biol Med
Peroxiredoxins (Prx) are enzymes that efficiently reduce hydroperoxides through active participation of cysteine residues (C(P), C(R)). The first step in catalysis, the reduction of peroxide substrate, is fast, 10(7) − 10(8) M(−1)s(−1) for huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f13cec28c20dc39d044e91e0402aa4
https://doi.org/10.1016/j.freeradbiomed.2019.07.016
https://doi.org/10.1016/j.freeradbiomed.2019.07.016
Autor:
John Knight, Alexandre Caron, Jayakumar Surendradoss, Oliver Chong, David A. Powell, Joyce Wu, Valerie Dumais, Aaron H. Graff, Samuel Gaudreault, Ding Jinyue, Renata Oballa, Andrew T. King, Tim Tang, Rajesh Gumpena, Jennifer H Cox, W. Todd Lowther, Marc-Olivier Boily
Publikováno v:
ACS Med Chem Lett
[Image: see text] Both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) influence the endogenous synthesis of oxalate and are clinically validated targets for treatment of primary hyperoxaluria (PH). We investigated whether dual inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2657ef881efc3975d21c823aaea40e
https://europepmc.org/articles/PMC8274068/
https://europepmc.org/articles/PMC8274068/
