Zobrazeno 1 - 10
of 481
pro vyhledávání: '"W T, Norton"'
Publikováno v:
The Journal of Immunology. 147:1522-1529
The cytotoxic effect of recombinant human cytokines was tested on glial cells cultured from mature bovine brain. Lymphotoxin (LT) and TNF induced injury to oligodendrocytes in a time and dose-dependent fashion. The other cytokines tested, IFN-gamma,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a566efb3b776c60332414cdb748bf3af
https://doi.org/10.4049/jimmunol.147.5.1522
https://doi.org/10.4049/jimmunol.147.5.1522
Publikováno v:
The Journal of Immunology. 144:129-135
The effect of cytokines on astrocytes cultured from mature bovine brain was determined both in a serum-containing medium and in a chemically-defined medium. The results showed that in serum-free medium, human TNF and, to a lesser degree, IL-6 and lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdff6b748082f483f597c77a85589e14
https://doi.org/10.4049/jimmunol.144.1.129
https://doi.org/10.4049/jimmunol.144.1.129
Autor:
W T, Norton
Publikováno v:
Neurochemical research. 24(2)
The proliferative behavior of glia following a cerebral stab wound in adult rats is reviewed. Proliferation was determined by both PCNA and [3H]thymidine labeling. Microglia were the first cells to divide and constituted the bulk of dividing cells. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8d0f8e5bf815d428fb1ef550b5dac3a
https://pubmed.ncbi.nlm.nih.gov/9972867
https://pubmed.ncbi.nlm.nih.gov/9972867
Publikováno v:
Glia. 22(1)
We have previously shown that a cortical stab wound induces the proliferation of microglia and astrocytes in situ, but no evidence was obtained for proliferation of cells of the oligodendrocyte lineage (Amat et al., 1996). To study further the proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c405cd9645b15bc14a584daea4fb6ae6
https://pubmed.ncbi.nlm.nih.gov/9436788
https://pubmed.ncbi.nlm.nih.gov/9436788
Autor:
D A, Aquino, E, Capello, J, Weisstein, V, Sanders, C, Lopez, W W, Tourtellotte, C F, Brosnan, C S, Raine, W T, Norton
Publikováno v:
Journal of neuropathology and experimental neurology. 56(6)
Recent studies have implicated heat shock proteins (HSP) in the pathogenesis of the multiple sclerosis (MS) lesion. Expression of the 73 kDa constitutive HSP (HSC70), the 72 kDa stress-inducible HSP (HSP70), and the 27 kDa small HSP (HSP27) was analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::687ec363fa26aafcd75bb52ef2fc2e02
https://pubmed.ncbi.nlm.nih.gov/9184657
https://pubmed.ncbi.nlm.nih.gov/9184657
Publikováno v:
Neurochemical research. 22(4)
Tumor necrosis factor-alpha induces oligodendrocytes apoptosis, and is known to stimulate the hydrolysis of sphingomyelin to form the lipid mediator, ceramide. These data encouraged us to determine whether ceramide itself is able to induce apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::315bb5125112da87600032bf353e2bec
https://pubmed.ncbi.nlm.nih.gov/9130266
https://pubmed.ncbi.nlm.nih.gov/9130266
Autor:
D. R. Beniac, R. A. Ridsdale, M. D. Luckevich, T. A. Tompkins, G. Harauz, J. Sedzik, S. Hjertén, E. Brekkan, P. Lundahl, Michael B. Tropak, John C. Roder, F. Giordano, B. Chang, A. M. La Ronde, A. Al-Sabbagh, M. Kretschmer, A. Asipu, G. E. Blair, B. Mak, M. A. Moscarello, R. Doucette, K. Gratto, V. Verge, J. Yeung, A. Nazarali, P. Murphy, P. Topilko, S. Schneider-Maunoury, T. Seitanidou, A. Baron-Van Evercooren, P. Charnay, M. J. Lee, A. Brennan, A. Tabernero, Z. Dong, A. Blanchard, G. Zoidl, K. R. Jessen, R. Mirsky, E. Couve, F. Cabello, J. Krsulovic, M. Roncagliolo, J. Li, E. L. Hertzberg, J. I. Nagy, Dirk H.-H. Neuberg, Patrizia Anzini, Eric Nelles, Klaus Willecke, Melitta Schachner, Rudolf Martini, Ueli Suter, R. Ankerhold, C. A. O. Stuermer, Karen J. Chandross, W. T. Norton, L. D. Hudson, R. I. Cohen, K. Asakura, S. F. Hunter, M. Rodriguez, Rashmi Bansal, Susan Winkler, S. E. Pfeiffer, Y. S. Oh., V. W. Yong, B. H. J. Juurlink, R. W. Griebel, R. M. Devon, A. Khorchid, G. Almazan, H.-N. Liu, G. W. Konat, Gu Jin, R. C. Wiggins, S. K. Thorburne, B. L. Bartnik, H. Marrif, L. Hertz, S. E. Jelinski, J. Y. Yager, M. R. Del Bigio, J. N. Kanfer, H. L. Weiner, P. A. Nelson, J. K. Dyer, J. Bourque, J. D. Steeves, Monika Labes, Arthur Roach, Parker L. Andersen, David J. Schreyer, J. L. Vanderluit, A. Peterson, W. Tetzlaff, C. O. Hanemann, A. Gabreëls-Festen, H. W. Mueller, L. A. Karchewski, V. M. K. Verge, M. Foldvari, M. R. Jaafari
Publikováno v:
Cell Biology and Pathology of Myelin ISBN: 9780306455957
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ccba320f138951e01d5cfe8aaa3194c
https://doi.org/10.1007/978-1-4615-5949-8_34
https://doi.org/10.1007/978-1-4615-5949-8_34
Autor:
W. T. Norton, M. L. Cuzner
Publikováno v:
Brain pathology (Zurich, Switzerland). 6(3)
The myelin sheath, a lipid-rich multilamellar membrane of relative stability, both insulates and enhances conduction in nerve axons. A notable feature of myelin-specific proteins, in particular myelin basic protein, is their susceptibility to prote-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99f57519daf5971564bfefcae7ce4c3
https://pubmed.ncbi.nlm.nih.gov/8864281
https://pubmed.ncbi.nlm.nih.gov/8864281
Publikováno v:
Glia. 16(4)
Brain injury induces reactive gliosis, characterized by increased expression of glial fibrillary acidic protein (GFAP), astrocyte hypertrophy, and hyperplasia of astrocytes and microglia. One hypothesis tested in this study was whether ganglioside GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::042e92bd6e1bb27e6228350b391c7e20
https://pubmed.ncbi.nlm.nih.gov/8721677
https://pubmed.ncbi.nlm.nih.gov/8721677
Publikováno v:
Acta neurobiologiae experimentalis. 50(4-5)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system commonly used as a model for multiple sclerosis. In both of these diseases demyelination occurs association with perivascular infil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c60c53b9c75e4a01fe3c10008834253a
https://pubmed.ncbi.nlm.nih.gov/2130645
https://pubmed.ncbi.nlm.nih.gov/2130645