Zobrazeno 1 - 10
of 30
pro vyhledávání: '"W T, Hum"'
Publikováno v:
Thrombosis and haemostasis. 63(3)
delta 2-89 t-PA is a deletion mutant lacking the finger (F) and epidermal growth factor (EGF) domains; thus, the fibrin interaction of this molecule must be mediated solely by the kringle region. In the present study, the influence of the oligosaccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a00c995f6da7b1e7cb30f12e329d1ea
https://pubmed.ncbi.nlm.nih.gov/2119528
https://pubmed.ncbi.nlm.nih.gov/2119528
Autor:
R Rappaport, W.-T. Hum, R. W. Hartzell, C Urbano, P. P. Hung, N. K. Kalyan, Shaw Guang Lee, J. Wilhelm, K. P. Fu
Publikováno v:
Journal of Biological Chemistry. 263:3971-3978
Tissue-type plasminogen activator (t-PA) is a mosaic protein containing several distinct structural domains attached to the serine protease catalytic unit present at its COOH terminus. To investigate structure-function relationships in t-PA, we delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6198a4d9a5f265856bf66c4adf448123
https://doi.org/10.1016/s0021-9258(18)69021-0
https://doi.org/10.1016/s0021-9258(18)69021-0
Publikováno v:
The Journal of Experimental Medicine
We previously demonstrated that loci closely linked to the Ly-3 locus control the expression of distinct sets of light chains in normal mouse serum immunoglobulin. One of these loci, IgK-Ef2, was shown to control two major bands in normal light chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69abb2c52b6349f66f42d8fe497fe953
https://doi.org/10.1084/jem.152.3.555
https://doi.org/10.1084/jem.152.3.555
Publikováno v:
Gene. 84:127-133
A 1.6 kb cDNA fragment encoding the mature part of the human tissue-type plasminogen activator (t-PA) was subcloned into a Bacillus subtilis dual plasmid expression system [Le Grice et al., Gene 55 (1987) 95-103]. Expression of the tPA gene in this v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcae2d1bdc03192c1837345431a405e
https://doi.org/10.1016/0378-1119(89)90146-7
https://doi.org/10.1016/0378-1119(89)90146-7
Autor:
J. Wilhelm, M Ronchetti-Blume, S M Cheng, R Rappaport, S Dheer, N. K. Kalyan, Shaw Guang Lee, C Urbano, R. W. Hartzell, W.-T. Hum
Publikováno v:
Journal of Biological Chemistry. 263:2917-2924
Recent data from several studies have suggested that the non-protease domains in tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) determine their biological specificities, including binding to fibrin clots and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c52d3c09ddf3f8a28a986590a12d82f
https://doi.org/10.1016/s0021-9258(18)69156-2
https://doi.org/10.1016/s0021-9258(18)69156-2
Publikováno v:
Journal of Endocrinology. 91:447-456
The effects of nucleotides and nucleosides on steroidogenesis and aerobic lactic-acid production were examined in unsectioned mouse adrenal glands preincubated for 1 h and then incubated for 2 h in Krebs–Ringer bicarbonate and 0·01 m-glucose mediu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbf599c52c8d086b75ddfa287983e22
https://doi.org/10.1677/joe.0.0910447
https://doi.org/10.1677/joe.0.0910447
Publikováno v:
Journal of Steroid Biochemistry. 8:243-245
High pressure liquid chromatography (HPLC) offers a rapid, qualitative as well as quantitative method for the determination of 18-hydroxydeoxycorticosterone and corticosterone. It is more rapid and more specific than existing methods for the estimati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8f7b05a03af267d34a151d16dfc1e4
https://doi.org/10.1016/0022-4731(77)90058-9
https://doi.org/10.1016/0022-4731(77)90058-9
Publikováno v:
Thrombosis research. 50(1)
The pharmacokinetic characteristics of delta 2-89 tPA, characterized by the deletion of the first 89 amino acids at the NH2-terminus of tPA, were evaluated and compared to those of recombinant tPA (rtPA). When they were administered intravenously to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f60720ed603d41c2ed6f4418d90ccc2
https://pubmed.ncbi.nlm.nih.gov/3135637
https://pubmed.ncbi.nlm.nih.gov/3135637
Autor:
N K, Kalyan, S G, Lee, J, Wilhelm, K P, Fu, W T, Hum, R, Rappaport, R W, Hartzell, C, Urbano, P P, Hung
Publikováno v:
The Journal of biological chemistry. 263(8)
Tissue-type plasminogen activator (t-PA) is a mosaic protein containing several distinct structural domains attached to the serine protease catalytic unit present at its COOH terminus. To investigate structure-function relationships in t-PA, we delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16fc0f2124d9da2dcaded4581c674568
https://pubmed.ncbi.nlm.nih.gov/3126183
https://pubmed.ncbi.nlm.nih.gov/3126183
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
The plasminogen activators, t-PA and u-PA, are glycoproteins known to be involved in homeostasis of the blood clotting system, and thus are of potential clinical use in the treatment of thrombosis. Several in vivo studies have shown that both t-PA an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffdace1d680d91c30764e6ff862ec495
https://doi.org/10.1055/s-0038-1643603
https://doi.org/10.1055/s-0038-1643603