The magnitude of the plasma hepcidin response to oral iron supplements depends on the iron dosage

Autor: Maximilian Karczewski, Stana Simic, Lanja Saleh, Albina Nowak, Morton G. Schubert, Diego Moretti, Dorine W. Swinkels, Felix Beuschlein, Paolo M. Suter, Pierre-Alexandre Krayenbuehl

Publikováno v: Swiss Medical Weekly, Vol 154, Iss 2 (2024)

BACKGROUND: Iron deficiency without anaemia is a common health problem, especially in young menstruating women. The efficacy of the usually recommended oral iron supplementation is limited due to increased plasma hepcidin concentration, which reduces

Externí odkaz: https://doaj.org/article/5a0dc387e1e44586b0cf4cd8baa7f584

Effectiveness of low-dose iron treatment in non-anaemic iron-deficient women: a prospective open-label single-arm trial

Autor: Stana Simic, Maximilian Karczewski, Silke Klapdor, Albina Nowak, Morton Schubert, Diego Moretti, Dorine W. Swinkels, Felix Beuschlein, Lanja Saleh, Paolo Suter, Pierre-Alexandre Krayenbuehl

Publikováno v: Swiss Medical Weekly, Vol 153, Iss 5 (2023)

BACKGROUND: Iron deficiency without anaemia is highly prevalent and is particularly associated with fatigue, cognitive impairment, or poor physical endurance. Standard oral iron therapy often results in intestinal irritation with associated side effe

Externí odkaz: https://doaj.org/article/58b4ea872a9949598564e6a649aea368

Kidney tubule iron loading in experimental focal segmental glomerulosclerosis

Autor: Rachel P. L. van Swelm, Sanne Beurskens, Henry Dijkman, Erwin T. G. Wiegerinck, Rian Roelofs, Frank Thévenod, Johan van der Vlag, Jack F. M. Wetzels, Dorine W. Swinkels, Bart Smeets

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Kidney iron deposition may play a role in the progression of tubulointerstitial injury during chronic kidney disease. Here, we studied the molecular mechanisms of kidney iron loading in experimental focal segmental glomerulosclerosis (FSGS)

Externí odkaz: https://doaj.org/article/aa89f4d3a9384e2299ca2096925f5c50

Correction: Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context.

Autor: Healthy Brain Study consortium, Esther Aarts, Agnes Akkerman, Mareike Altgassen, Ronald Bartels, Debby Beckers, Kirsten Bevelander, Erik Bijleveld, Esmeralda Blaney Davidson, Annemarie Boleij, Janita Bralten, Toon Cillessen, Jurgen Claassen, Roshan Cools, Ineke Cornelissen, Martin Dresler, Thijs Eijsvogels, Myrthe Faber, Guillén Fernández, Bernd Figner, Matthias Fritsche, Sascha Füllbrunn, Surya Gayet, Marleen M H J van Gelder, Marcel van Gerven, Sabine Geurts, Corina U Greven, Martine Groefsema, Koen Haak, Peter Hagoort, Yvonne Hartman, Beatrice van der Heijden, Erno Hermans, Vivian Heuvelmans, Florian Hintz, Janet den Hollander, Anneloes M Hulsman, Sebastian Idesis, Martin Jaeger, Esther Janse, Joost Janzing, Roy P C Kessels, Johan C Karremans, Willemien de Kleijn, Marieke Klein, Floris Klumpers, Nils Kohn, Hubert Korzilius, Bas Krahmer, Floris de Lange, Judith van Leeuwen, Huaiyu Liu, Maartje Luijten, Peggy Manders, Katerina Manevska, José P Marques, Jon Matthews, James M McQueen, Pieter Medendorp, René Melis, Antje Meyer, Joukje Oosterman, Lucy Overbeek, Marius Peelen, Jean Popma, Geert Postma, Karin Roelofs, Yvonne G T van Rossenberg, Gabi Schaap, Paul Scheepers, Luc Selen, Marianne Starren, Dorine W Swinkels, Indira Tendolkar, Dick Thijssen, Hans Timmerman, Rayyan Tutunji, Anil Tuladhar, Harm Veling, Maaike Verhagen, Jasper Verkroost, Jacqueline Vink, Vivian Vriezekolk, Janna Vrijsen, Jana Vyrastekova, Selina van der Wal, Roel Willems, Arthur Willemsen

Publikováno v: PLoS ONE, Vol 17, Iss 4, p e0267071 (2022)

[This corrects the article DOI: 10.1371/journal.pone.0260952.].

Externí odkaz: https://doaj.org/article/da5c348b79064f2baeef684ed0f5ebca

Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis

Autor: Wenke Moris, Pauline L. M. Verhaegh, Ad A. M. Masclee, Dorine W. Swinkels, Coby M. Laarakkers, Ger H. Koek, Cees Th. B. M. vanDeursen

Publikováno v: Clinical Case Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)

Abstract We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the inna

Externí odkaz: https://doaj.org/article/e59ed57f1713497484ab60d64879eba8