Zobrazeno 1 - 10
of 90
pro vyhledávání: '"W Steven Ward"'
Publikováno v:
Asian Journal of Andrology, Vol 17, Iss 4, Pp 610-615 (2015)
The highly condensed chromatin of mammalian spermatozoa is usually considered to be biologically inert before fertilization. However, we have demonstrated that even in this compacted state, sperm chromatin is subject to degradation at open configurat
Externí odkaz:
https://doaj.org/article/477b6d75153d440a9e8f235501ed8087
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56385 (2013)
Mouse zygotes do not activate apoptosis in response to DNA damage. We previously reported a unique form of inducible sperm DNA damage termed sperm chromatin fragmentation (SCF). SCF mirrors some aspects of somatic cell apoptosis in that the DNA degra
Externí odkaz:
https://doaj.org/article/1b5927ff67da447895c7cd543ab3d63d
Autor:
Jordi Ribas-Maynou, Ariadna Delgado-Bermúdez, Yentel Mateo-Otero, Estel Viñolas, Carlos O. Hidalgo, W. Steven Ward, Marc Yeste
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract Background The analysis of chromatin integrity has become an important determinant of sperm quality. In frozen-thawed bovine sperm, neither the sequence of post-thaw injury events nor the dynamics of different types of sperm DNA breaks are w
Externí odkaz:
https://doaj.org/article/1c6884ab7ff44f4ca50b410cc7ab7257
Publikováno v:
Molecular Human Reproduction, 2022, vol. 28, núm. 9, p. gaac029
Articles publicats (D-B)
Ribas Maynou, Jordi Nguyen, Hieu Valle, Raquel Wu, Hongwen Yeste Oliveras, Marc Ward, W.Steven 2022 Sperm degradation after vasectomy follows a sperm chromatin fragmentation dependent mechanism causing DNA breaks in the toroid linker regions Molecular Human Reproduction 28 9 gaac029
DUGiDocs – Universitat de Girona
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Articles publicats (D-B)
Ribas Maynou, Jordi Nguyen, Hieu Valle, Raquel Wu, Hongwen Yeste Oliveras, Marc Ward, W.Steven 2022 Sperm degradation after vasectomy follows a sperm chromatin fragmentation dependent mechanism causing DNA breaks in the toroid linker regions Molecular Human Reproduction 28 9 gaac029
DUGiDocs – Universitat de Girona
instname
Vasectomy is a widely used surgical technique creating an obstructive azoospermia. Although sperm cannot be ejaculated, the testis maintains sperm production in vasectomized males. The continuous accumulation of sperm deposited in the epididymis and
Publikováno v:
Syst Biol Reprod Med
The Origin Replication Complex subunit 4 (ORC4) is one in six subunits of the Origin Replication Complexes (ORCs) which is essential for initiating licensing at DNA replication origins and recruiting adaptor molecules necessary for various cellular p
Publikováno v:
Results Probl Cell Differ
Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine ISBN: 9783031065729
Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine ISBN: 9783031065729
Sperm nuclei present a highly organized and condensed chromatin due to the interchange of histones by protamines during spermiogenesis. This high DNA condensation leads to an almost inert chromatin, with the impossibility of conducting gene transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52345ffb87a46c1532f14f499bd0fcf
https://europepmc.org/articles/PMC9671218/
https://europepmc.org/articles/PMC9671218/
Autor:
Monika A. Ward, W. Steven Ward
Publikováno v:
Biology of Reproduction. 100:1-7
Autor:
Cindy T Vuong, W. Steven Ward, Thien P N Nguyen, David M. Jameson, Michael A. Ortega, Nicholas G. James, Hieu Nguyen, Lynn Nguyen
Publikováno v:
Journal of Cellular Biochemistry. 118:2941-2949
We have previously shown that the DNA replication licensing factor ORC4 forms a cage around the chromosomes that are extruded in both polar bodies during murine oogenesis, but not around the chromosomes that are retained in the oocyte or around the s
Publikováno v:
Journal of Cellular Biochemistry. 117:1806-1812
After fertilization, the maternal and paternal chromosomes independently proceed through pronuclear formation. These chromatin reconfigurations occur within a shared cytoplasm thus exposing both gametes to the same factors. Here, we report that conti
Autor:
W. Steven Ward
Publikováno v:
Translational Andrology and Urology
In this issue, Agarwal and colleagues (1) have attempted the Herculean effort of sifting through hundreds of publications and several meta-analyses of those publications to answer a question that continues to plague clinicians in artificial reproduct