Výsledky vyhledávání

Akademický článek

The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival

Autor: Shubin W. Shahab, Christianna M. Roggeveen, Jiarong Sun, Haritha Kunhiraman, Leon F. McSwain, Kyle Juraschka, Sachin A. Kumar, Olivier Saulnier, Michael D. Taylor, Matthew Schniederjan, Robert W. Schnepp, Tobey J MacDonald, Anna Marie Kenney

Publikováno v: Molecular Oncology, Vol 17, Iss 9, Pp 1784-1802 (2023)

Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of available targeted therapy. Expression of protein lin‐28 homolog B

Externí odkaz: https://doaj.org/article/93a4f4cb469a4d629a58e2ccc4aa8c54

Zobrazit plný text záznamu

Akademický článek

Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

Autor: Cara E. Shields, Sindhu Potlapalli, Selma M. Cuya‐Smith, Sarah K. Chappell, Dongdong Chen, Daniel Martinez, Jennifer Pogoriler, Komal S. Rathi, Shiv A. Patel, Kristianne M. Oristian, Corinne M. Linardic, John M. Maris, Karmella A. Haynes, Robert W. Schnepp

Publikováno v: Molecular Oncology, Vol 15, Iss 8, Pp 2156-2171 (2021)

Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma. There are two main subtypes of RMS, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. ARMS typically encompasses fusion‐positive rhabdomyosarcoma, which expresses

Externí odkaz: https://doaj.org/article/54ae8d279f04470ca6884d0bbba468ac

Zobrazit plný text záznamu

Akademický článek

LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase

Autor: Dongdong Chen, Julie Cox, Jayabhargav Annam, Melanie Weingart, Grace Essien, Komal S. Rathi, Jo Lynne Rokita, Priya Khurana, Selma M. Cuya, Kristopher R. Bosse, Adeiye Pilgrim, Daisy Li, Cara Shields, Oskar Laur, John M. Maris, Robert W. Schnepp

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 6, Pp 231-241 (2020)

Neuroblastoma is an aggressive pediatric malignancy of the neural crest with suboptimal cure rates and a striking predilection for widespread metastases, underscoring the need to identify novel therapeutic vulnerabilities. We recently identified the

Externí odkaz: https://doaj.org/article/ad151ae47c9f49dea91c5b91b570dcb8

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání